A5038750304- EEG and Brain-Computer Interfaces
- ECG Monitoring and Analysis
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lysosomal Storage Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Blind Source Separation Techniques
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Diamond and Carbon-based Materials Research
- Marine Biology and Environmental Chemistry
- Gaze Tracking and Assistive Technology
- ATP Synthase and ATPases Research
- Nerve injury and regeneration
- Metal and Thin Film Mechanics
National Yang Ming Chiao Tung University
2025
RMIT University
2021-2023
Linkou Chang Gung Memorial Hospital
2023
Chang Gung University
2023
National Sun Yat-sen University
2023
Sleep scoring involves the inspection of multimodal recordings sleep data to detect potential disorders. Given that symptoms disorders may be correlated with specific stages, diagnosis is typically supported by simultaneous identification a stage and disorder. This paper investigates automatic recognition stages from sensory (EEG, ECG, EMG). We propose new distributed multilabel decision-making system (MML-DMS). It comprises several interconnected classifier modules, including deep...
We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect mechanism, we present evidence here that lack dAux enhanced phosphorylation autophagy-related protein Atg9 at two newly threonine residues, T62 and T69. The absence promotes autophagosome formation trafficking autophagosomes glia. Whereas expression non-phosphorylatable variants suppresses dAux-induced increase...
Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly be beneficial or detrimental under pathological conditions, like promoting eliminating SNCA/α-syn (synuclein alpha) inclusions, remains elusive. Here we present evidence that aux (auxilin), Drosophila homolog PD risk factor GAK (cyclin G associated kinase), regulates lysosomal degradation in glia. Lack glial GAK/aux increases lysosome number and size, acidification hydrolase activity, ultimately...
Existing automatic sleep stage detection methods predominantly use convolutional neural network classifiers (CNNs) trained on features extracted from single-modality signals such as electroencephalograms (EEG). On the other hand, multimodal approaches propose very complexly stacked structures with multiple CNN branches merged by a fully connected layer. It leads to high computational and data requirements. This study proposes replacing distributed system for detection. has relatively low...
High-quality evidence indicated that both neoadjuvant carboplatin/paclitaxel (CROSS) and cisplatin/5-fluorouracil (PF) regimens in combination with radiotherapy improve survival outcomes compared to surgery alone patients esophageal cancer. It is not yet known whether they may differ terms of treatment burden healthcare costs. A total 232 Taiwanese squamous cell carcinoma who had undergone chemoradiotherapy (nCRT) either the CROSS (n = 153) or PF 79) were included. Hospital encounters...
This retrospective study examined outcomes in esophageal squamous cell carcinoma (ESCC) patients who did not undergo surgical resection after neoadjuvant chemoradiotherapy (nCRT).Patients receiving nCRT between 2012 and 2020 were divided into two groups: group 1 (scheduled surgery) 2 (no surgery). Group was further categorized subgroups based on reasons for proceeding to surgery: 2a (disease progression), 2b (poor general conditions), 2c (patient refusal). Overall survival (OS) the primary...
This study investigates the problem of automatic sleep stage recognition using EEG signals collected simultaneously from multiple sensors (electrodes). Given that multichannel diagnosis does not always lead to an anonymous agreement between diagnostic channels (assessors), question was how arbitrate different assessors determine a final diagnosis. A multi-channel classification system consisting interconnected neural networks tested and compared with baseline single-channel approaches method...