A5091085154- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- PI3K/AKT/mTOR signaling in cancer
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- Peroxisome Proliferator-Activated Receptors
- Retinal Diseases and Treatments
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Cytomegalovirus and herpesvirus research
Jinan University
2014-2024
First Affiliated Hospital of Jinan University
2022-2024
Henan Tianguan Group (China)
2024
Sun Yat-sen University Cancer Center
2018-2023
Sun Yat-sen University
2018-2023
Eye & ENT Hospital of Fudan University
2013
Acute promyelocytic leukemia (APL) is characterized by the reciprocal translocation t(15;17), which fuses PML with retinoic acid receptor alpha (RARα). Although PML-RARα crucially important for pathogenesis and responsiveness to treatment, molecular cellular mechanisms exerts its oncogenic potential have not been fully elucidated. Recent reports suggested that long non-coding RNAs (lncRNAs) contribute precise control of gene expression are involved in human diseases. Little known about role...
Acute promyelocytic leukemia (APL) is associated with chromosomal translocation t(15;17), which results in the proliferation of morphologically abnormal promyelocytes. Gain supernumerary copies 8q24 region, harbors MYC and PVT1, has been shown to be most common secondary alteration human APL. Increased can accelerate development myeloid However, role that expression long non-coding RNA (lncRNA) PVT1 plays pathogenesis APL remains largely unknown. In this study, we first analyzed lncRNA level...
Abstract Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the exhaustion T cells, and blockade PD-1 pathway an effective immunotherapeutic strategy for treating various cancers. However, response rates are limited, many patients do not achieve durable responses. Thus, it important to seek additional strategies that can improve anticancer immunity. Here, we report bromodomain extraterminal domain (BET) inhibitor JQ1 inhibits in Jurkat primary T-cell models....
Abstract Venetoclax, an inhibitor that selectively targets B cell lymphoma-2 (BCL-2) has been approved for treating adult acute myeloid leukemia (AML) in combination with hypomethylating agents. However, its short duration of response and emergence resistance are significant issues. In this study, we found the sensitivity AML cells to venetoclax was considerably enhanced by ML385, ferroptosis factor nuclear transcription erythroid 2-related 2 (NRF2). Using samples, verified NRF2 target gene...
Immunotherapy utilizing T cells that attack tumors is a promising strategy for treatment, but immune suppressive cell subsets, such as regulatory (Treg), and checkpoint molecules, including programmed death-1 (PD-1), can suppress the intensity of reaction thereby impair tumor clearance. Cluster differentiation 69 (CD69), known an early leukocyte activation marker, be used measure or marker activation. In recent years, functions CD69 in regulation Treg/Th17 (T helper 17) tissue retention have...
T-cell malignancies, including acute lymphoblastic leukemia (T-ALL) and lymphoma (TCL), are characterized by inferior treatment effects, high heterogeneity, poor prognosis, a lack of specific therapeutic targets drugs to improve outcome. Disulfiram (DSF) is drug used clinically control alcoholism that has recently been shown be cytotoxic for multiple cancers. However, the underlying effects mechanisms DFS in patients with malignancies not well characterized. In this study, we report DSF...
Acute myeloid leukemia (AML) is an aggressive heterogeneous hematological malignancy with remarkably outcomes. This study aimed to identify potential biomarkers for AML risk stratification via analysis of gene expression profiles.RNA sequencing data from 167 adult patients in the Cancer Genome Atlas (TCGA) database were obtained overall survival (OS) analysis, and 52 bone marrow (BM) samples our clinical center used validation. Additionally, siRNA was investigate role prognostic genes...
Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate (PMA). However, little is known about mechanism responsible for regulating this differentiation process. Here, we performed high-throughput RNA-Seq analysis to investigate genes differently expressed in treated and without PMA examined those may PMA-induced of monocytes macrophages. We found 3,000 differentially after...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of with poor prognosis, and biomarkers novel therapeutic targets are urgently needed for this disease. Our previous studies have found that inhibition the B-cell leukemia/lymphoma 11B ( BCL11B ) gene could significantly promote apoptosis growth retardation T-ALL cells, but molecular mechanism underlying effect remains unclear. This study intends to investigate genes downstream further explore its function in cells....
Epstein-Barr virus (EBV) is a human cancer-related closely associated with lymphoid and epithelial malignancies, EBV glycoprotein B (gB) plays an essential role in viral entry into both cells by promoting cell-cell fusion. gB exclusively modified high-mannose-linked N-glycans primarily localizes to the endoplasmic reticulum (ER) low levels on plasma membrane (PM). However, mechanism through which regulated within host largely unknown. Here, we report identification of F-box only protein 2...
Abstract Background Despite advances in the treatment of acute promyelocytic leukemia (APL) with all‐ trans ‐retinoic acid (ATRA), its underlying mechanism has not been fully elucidated. The oncogenic microRNA cluster miR‐17‐92 modulates multiple cellular processes, including survival, proliferation, and apoptosis. However, role regulation yet documented for APL. Methods We analyzed expression APL samples cell lines by qRT‐PCR. c‐Myc was measured western blot. Cell differentiation assessed...
Abstract Background Physalin B (PB) from Physalis angulata L . (Solanaceae) is a naturally occurring secosteroid with multiple biological activities, including anti‐inflammatory and anticancer activity. However, PB's effects mechanisms in human gastric cancer (GC) cells are not well characterized. Methods The undifferentiated GC cell line HGC‐27 semi‐differentiated SGC‐7901 were treated PB. Cell counting kit‐8 (CCK‐8) colony formation assays performed to evaluate viability. Apoptosis the...
Objective T cell dysfunction is a common characteristic of patients with myeloid leukemia and closely related to clinical efficacy prognosis. In order clarify the mechanisms leading dysfunction, we characterized gene expression profile cells from chronic myelogenous (CML) by microarray analysis investigated regulating pathway.Methods We employed profiling, bioinformatics real-time quantitative reverse transcription PCR (RT-qPCR) detect genes differentially expressed in CML versus healthy...
Abstract Background Acute myeloid leukemia (AML) is a malignant clonal blood disease and the most common type of acute in adults. Despite continuous advances treatments, long-term prognosis AML has not improved substantially. Tissue-resident memory T cells (TRMs) infiltrating solid tumors could influence tumor progression response to immune therapies; however, proportion prognostic significance TRMs bone marrow (BM) patients with are unclear. Methods We use flow cytometry assay phenotypic 49...
Tissue-resident memory T (TRM) cells infiltrating solid tumors could influence tumor progression and the response to immune therapies. However, proportion prognostic value of TRM in bone marrow (BM) patients with acute myeloid leukemia (AML) are unclear. In this study, we used flow cytometry assay phenotype 49 BM samples from newly diagnosed AML (ND-AML). We found that CD8 + effector (TEM) highly expressed CD69 (CD8 TRM-like cells), their percentage was significantly increased ND-AML...