A5100319722- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Impairment Studies
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Lymphoma Diagnosis and Treatment
- Retinal Imaging and Analysis
- Pituitary Gland Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Air Quality and Health Impacts
- Botulinum Toxin and Related Neurological Disorders
- Retinal and Macular Surgery
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinal Development and Disorders
- Kruppel-like factors research
- Advanced Radiotherapy Techniques
- CNS Lymphoma Diagnosis and Treatment
- Advanced Differential Geometry Research
Eye & ENT Hospital of Fudan University
2013-2025
Fudan University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
State Key Laboratory of Medical Neurobiology
2021-2025
Shanghai Medical College of Fudan University
2022-2025
Shanghai Clinical Research Center
2024
Shanghai Eye Disease Prevention & Treatment Center
2024
Antwerp University Hospital
2023
University of Antwerp
2023
University of Iowa
2022
To investigate dry eye disease (DED) and risk factors in patients with depressive or anxiety disorders at a psychiatric clinic China.Cross-sectional study. Subjects (≥16 years) who had were evaluated history, questionnaires (Self-rating Anxiety Scale, Self-rating Depression Ocular Surface Disease Index), examination.There 472 the study, including 176 (37%) depression, 170 (36%) generalized disorder, 60 (13%) depression 55 (12%) obsessive-compulsive 11 (2%) panic disorder. DED was present 283...
Abstract Glaucoma is now viewed not just a disease of the eye but also brain. The prognosis glaucoma critically depends on how early can be detected. However, glaucomatous loss laminar functions in human lateral geniculate nucleus (LGN) and superior colliculus (SC) remains difficult to detect poorly understood. Using functional MRI, we measured neural signals from different layers LGN SC, as well visual cortices (V1, V2 MT), patients with early‐stage normal controls. Compared controls,...
Objective To compare corneal biomechanical properties, measured by a newly developed tonometer (Corneal Visualization Scheimpflug Technology, Corvis ST), in untreated primary open angle glaucoma (POAG) patients, POAG patients with long-term topical prostaglandin analog (PGA) therapy and normal controls. Further is to investigate the potential effects of PGA on biomechanics. Methods In this case-control study, 35 consecutive medication naïve eyes POAG, 34 at least 2 years treatment 19 were...
To use optical coherence tomography (OCT) angiography and a split-spectrum amplitude-decorrelation algorithm to evaluate the changes in macular vascular system after uncomplicated phacoemulsification.Department of Ophthalmology, Eye Ear, Nose, Throat Hospital Fudan University, Shanghai, China.Prospective case series.Patients with senile cataracts were included. Retinal vessel density thickness at area checked by OCT baseline 1 week, month, 3 months cataract surgery.Thirty-two eyes (32...
Background Myopia poses a global health concern and is influenced by both genetic environmental factors. The incidence of myopia tends to increase during infectious outbreaks, such as the COVID-19 pandemic. This study examined screen-time behaviors among Chinese children adolescents investigated efficacy artificial intelligence (AI)-based alerts in modifying practices. Methods A cross-sectional analysis was performed using data from 6,716 with AI-enhanced tablets that monitored recorded...
Decades of research have established the toxicity soot particles resulting from incomplete combustion. However, unique chemical compounds responsible for adverse health effects remained uncertain. This study utilized mass spectrometry to analyze composition extracted organics at three oxidation states, aiming establish quantitative relationships between potentially toxic chemicals and their impact on human alveolar basal epithelial cells (A549) through metabolomics-based evaluations....
Abstract Disruption of retinal input early in life can lead to amblyopia, a condition characterized by reduced visual acuity after optical correction. While functional abnormalities the areas have been observed mesoscale deficits cortical microcircuitry across depth remain unexplored humans. Using combination submillimeter 7T fMRI and EEG frequency-tagging methods, we investigated neural monocular processing binocular interactions human adults with unilateral amblyopia. The results revealed...
Abstract Neurodevelopmental and neurodegenerative disorders are often associated with selective deficits in the parallel pathways of human visual system. Effective intervention is crucial for improving treatment outcomes prognosis. In this study, a novel altered reality (AR) method developed to improve pathway‐specific functions adults normal vision amblyopia, common developmental disorder. To selectively enhance parvocellular pathway, which notably impaired low spatial frequency (SF)...
Objectives To examine the knowledge, attitude and practice (KAP) regarding immune-related adverse events (irAEs) nutritional support among patients with liver cancer (LC). Design Cross-sectional study. Setting Recruitment was carried out at Haikou People’s Hospital, Haikou, China, from December 2022 to April 2023. Participants Patients undergoing immunotherapy for LC. Primary secondary outcome measures Mean attitudes, practices, lifestyle scores were assessed using an investigator-designed...
How abnormal visual experiences early in life influence human subcortical pathways is poorly understood. Using high-resolution fMRI and pathway-selective stimuli, we investigate the of amblyopia on response properties effective connectivity adult brain. Compared to normal fellow eyes, stimuli presented amblyopic eye show selectively reduced parvocellular layers lateral geniculate nucleus weaker V1. eye, chromatic stimulus decreases superficial superior colliculus, while robustly increases...
To compare the surgical amount of unilateral medial rectus recession and lateral resection (RR) in patients with acute acquired comitant esotropia (AACE) versus common forms to provide dose-response reference for planning AACE.Retrospective study.Consecutive who underwent RR AACE or correction from January 2018 2022. Only achieved motor sensory success a minimum follow-up 3 months were analyzed.Group differences (MR) (LR) analyzed using multivariate regression models. Surgical dose responses...
Purpose: This study investigated a novel motion-on-color paradigm to functionally isolate the magnocellular pathway and evaluate its diagnostic value in preperimetric glaucoma patients. Methods: Thirty patients with primary open-angle 30 controls participated this study. They were tested both foveal peripheral locations. Contrast sensitivity was assessed for direction discrimination of moving luminance-modulated grating presented on top red/green isoluminant grating. The test designed target...
The 2021 WHO guidelines stress the importance of measuring ultrafine particles using particle number concentration (PNC) for health assessments. However, commonly used metrics such as aerodynamic diameter and concentrations do not fully capture diverse chemical makeup complex particles. To address this issue, our study high-throughput mass spectrometry to analyze properties cooking oil fumes (COFs) in real time evaluate their impact on BEAS-2B cell metabolism. Results showed insignificant...
The purpose of this study was to explore the cortical deficits patients with acquired concomitant esotropia (AACE) using resting-state functional magnetic resonance imaging (rs-fMRI) technique.Rs-fMRI signals from 25 AACE and matched controls were collected. repeated-measures analysis variance (RM-ANOVA) test two-sample t-test used investigate statistical differences amplitudes low-frequency fluctuation (ALFF) correlation performed validate relationship signal change clinical features.The...
Biodiesel, derived from alkyl esters of vegetable oils or animal fats, has gained prominence as a greener alternative to diesel due its reduced particle mass. However, it remains debatable whether biodiesel exposure more severe health issues than diesel. This study performed high-resolution mass spectrometry examine the detailed chemical compositions and lipidomics analysis human lung epithelial cells treated with emissions fuels. Results show presence peak substances CHO compounds in...
To investigate the fixation patterns in severe amblyopia with eccentric or central by MP-1 microperimeter.Fixation test was performed on 38 patients using microperimeter, 20 (EF group), and 18 (CF group). Fixation location stability were quantified preferred eccentricity bivariate contour ellipse area (BCEA, deg2) respectively. Comparisons of BCEA between amblyopic fellow eyes (FE) both groups (AE) analyzed. Linear regression analysis used to risk factors for instability fixation.In EF...
Abstract Purpose Decreased binocular and oculomotor function in strabismics has recently been considered as cortical origin. This study aimed to investigate functional abnormalities using a frequency‐specific neuroimaging method patients with concomitant exotropia (XT), demonstrate the clinical implications. Methods Resting‐state magnetic resonance imaging data were collected 26 XT matched controls. To evaluate local spontaneous neural activity, amplitude of low frequency fluctuations (ALFF)...
Abstract Background The study is to investigate the influence of high myopia on consistency between optical coherence tomography (OCT) and visual field in primary open-angle glaucoma (POAG). Methods We enrolled 37 patients with POAG (POAG-HM group), 27 without (POAG 29 controls (HM group). All subjects underwent Humphrey perimetry (30–2 10–2 algorithms). peripapillary retinal nerve fiber layer (RNFL) macular ganglion cell-inner plexiform (GCIPL) thicknesses were measured using Cirrus HD-OCT....