A5109725514- Connexins and lens biology
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Heat shock proteins research
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Bone health and osteoporosis research
- Gastrointestinal Tumor Research and Treatment
- Urinary and Genital Oncology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Interference and Gene Delivery
- Advanced Breast Cancer Therapies
- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- Myasthenia Gravis and Thymoma
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
Guangzhou Medical University
2024-2025
Third Affiliated Hospital of Guangzhou Medical University
2024-2025
Nanjing Medical University
2011-2024
Jiangsu Province Hospital
2023-2024
Wuxi People's Hospital
2010-2024
Chongqing Medical University
2024
Chongqing University
2024
Vision Technology (United States)
2024
Soochow University
2015-2024
First People's Hospital of Chongqing
2024
Morphological evidence shows that osteocytes, bone cells exist enclosed within matrix, are connected to one another and surface osteoblasts via gap junctions; however, it is unknown whether these junctions functional. Using a newly established murine osteocytic cell line MLO-Y4, we have examined functional junctional intercellular communication (GJIC) between osteoblastic cells. In our hands, MLO-Y4 express phenotypic characteristics of including stellate morphology, low alkaline phosphatase...
The strong correlation between a bone's architectural properties and the mechanical forces that it experiences has long been attributed to existence of cell not only detects load but also structurally adapts bone matrix counter it. One most likely cellular candidates for such “mechanostat” is osteocyte, which resides within mineralized perfectly situated detect mechanically induced signals. However, as osteocytes can neither form nor resorb bone, hypothesized they orchestrate remodeling by...
Lycopene is widely used in foods, cosmetics, nutritional supplements, and pharmaceuticals. Microbial production of lycopene has been intensively studied. However, there are few systematic engineering studies on Saccharomyces cerevisiae aimed at achieving high-yield production. In the current study, by employing a optimization strategy, we screened key biosynthetic genes, crtE, crtB, crtI, from diverse organisms. By adjusting copy number these three knocking out endogenous bypass increasing...
Forkhead transcription factor FoxO3a has been reported to have ambiguous functions and distinct mechanisms in various solid tumors, including glioblastoma (GBM). Although a preliminary analysis of small sample patients indicated that aberrations glioma might be related aggressive clinical behavior, the significance remains unclear. We investigated expression cohort 91 specimens analyzed correlations protein with patient prognosis. Furthermore, functional impact on GBM progression underlying...
Circulating tumor cells (CTCs) have been described as a population of that may seed metastasis, which is reliable target for the prevention metastases in lung cancer patients at early stage. The culturing CTCs vitro can be used to study mechanism metastasis and screen antimetastasis drugs. This aims establish CTC cell line explore potential its metastasis. A mixture EpCAM- EGFR-coated immunomagnetic microbeads microfluidic Herringbone-Chip was capture CTCs. CTCs, 95-D A549 evaluated by...
Background and objective We aimed to predict the targets signal pathways of Xiao-Chai-Hu-Tang (XCHT) in treatment colorectal cancer (CRC) based on network pharmacology, just as well further analyze its anti-CRC material basis mechanism action. Methods adopted Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) Integrated (TCMID) databases screen active ingredients potential XCHT. CRC-related were retrieved by analyzing published microarray data (accession number GSE110224)...
Gap junctional channels facilitate intercellular communication and in doing so may contribute to cellular differentiation. To test this hypothesis, we examined gap junction expression function a temperature-sensitive human fetal osteoblastic cell line (hFOB 1.19) that when cultured at 37°C proliferates rapidly but 39.5°C slowly displays increased alkaline phosphatase activity osteocalcin synthesis. We found hFOB 1.19 cells express abundant connexin 43 (Cx43) protein mRNA. In contrast, Cx45...
This study aimed to explore the causal relationships between cathepsins and cardiovascular diseases (CVDs) by Mendelian randomization (MR) analysis.
Regulatory T cells (Tregs) and effector play critical roles in tumor immunity, with Tregs suppressing immune responses contributing to an immunosuppressive microenvironment (TME). Neuritin-1 (Nrn), a neuropeptide, has been identified enhance Treg expansion. However, its role cell biology development remains unclear. We demonstrated that Nrn is highly expressed the in-vitro-induced (iTregs). Functionally, promoted iTreg differentiation dose-dependent manner, while deletion or anti-Nrn...
Gap junctional channels between cells provide a pathway for exchange of regulatory ions and small molecules. We previously demonstrated that expression connexins cell-to-cell communication parallel osteoblastic differentiation nonspecific pharmacological inhibitors gap inhibit alkaline phosphatase activity. In this study, we stably transfected connexin (Cx)43 antisense cDNA into the immortalized human fetal cell line hFOB 1.19 (hFOB/Cx43 − ). hFOB/Cx43 express lower levels Cx43 protein mRNA...
TRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported be up-regulated or down-regulated in many cancer types, suggesting oncogenic function of may depend on different molecular signaling pathway. was found that β-catenin (a key molecule Wnt pathway) required for TRIM29's effects. gene expression also heterogeneous non-small-cell lung (NSCLC) subtypes. In this study, possible associations with clinicopathological factors, prognosis, and human NSCLC were...
Abstract Aging demonstrates deleterious effects upon the skeleton which can predispose an individual to osteoporosis and related fractures. Despite well‐documented evidence that aging decreases bone formation, there remains little understanding whereby cellular alters skeletal homeostasis. We, others, have previously demonstrated gap junctions—membrane‐spanning channels allow direct cell‐to‐cell conductance of small signaling molecules—are critically involved in osteoblast differentiation We...
Arctigenin (ATG), a major bioactive substance of Fructus Arctii, counters renal fibrosis; however, whether it protects against paraquat (PQ)-induced lung fibrosis remains unknown. The present study was to determine the effect ATG on PQ-induced in mouse model and underlying mechanism. Firstly, we found that suppressed pulmonary by blocking epithelial-mesenchymal transition (EMT). reduced expressions Vimentin α-SMA (lung markers) induced PQ restored E-cadherin Occludin (two epithelial vivo...