A5101680918- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Bone Metabolism and Diseases
- Electrospun Nanofibers in Biomedical Applications
- Animal Virus Infections Studies
- Titanium Alloys Microstructure and Properties
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Surface Treatment and Residual Stress
- SARS-CoV-2 and COVID-19 Research
- Bone and Dental Protein Studies
- Dental materials and restorations
- Calcium Carbonate Crystallization and Inhibition
- Medicinal Plant Pharmacodynamics Research
Jiangsu Normal University
2014-2023
Chongqing University
2008-2014
Georgia Institute of Technology
2014
Nanjing University of Information Science and Technology
2013
Southwest University
2011
University of California, Riverside
2009
To investigate the influence of surface-functionalized substrates with nanostructures on behaviors mesenchymal stem cells, we conjugated bone morphogenetic protein 2 (BMP2) onto TiO2 nanotubes different diameter sizes 30, 60, and 100 nm for in vitro study. Polydopamine was employed as intermediate layer conjugation BMP2. The successful BMP2 revealed by field-emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), contact angle measurements. Immunofluorescence...
Background: The purpose of this study was to investigate the influences nanoscale wear particles derived from titanium/titanium alloy-based implants on integration bone. Here we report potential impact titanium oxide (TiO 2 ) nanoparticles adhesion, migration, proliferation, and differentiation mesenchymal stem cells (MSC) cellular level molecular in Wistar rat. Methods: A series TiO (14 nm, 108 196 nm) were synthesized characterized by scanning electron microscopy transmission microscopy,...
The size-mediated cytotoxicity of TiO2 nanoparticles is investigated at the cellular and molecular levels. dramatically increases around a particle size 100 nm (nanoscale effect). This finding affords new insights into nanomaterials, has potential implications in design nanostructured biomaterials. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
Surface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that differentiation microtextured titanium substrates is dependent alpha-2 beta-1 (α2β1) integrin signaling. This study used focused ion beam milling and scanning electron microscopy, combined with three-dimensional image reconstruction, to investigate early interactions of individual cells their substrate the α2β1 cell shape. MG63 osteoblast-like sand blasted/acid...
Abstract Surface topography of a biomaterial plays an essential role in the regulation cell adhesion, proliferation, and differentiation. To investigate influence hierarchically micro/nano‐structured substrates on differentiation mesenchymal stem cells (MSCs), series micro‐, nano‐, titanium were fabricated via dual acid etching and/or anodic oxidation. The morphologies characterized by field emission scanning electron microscopy (FE‐SEM) contact angle measurement, respectively. MSCs adhered...
The surface matters: Along with the degradation of multilayer structure, galactosylated chitosan/plasmid DNA complexes (see picture) were simultaneously formed in situ for cell uptake and gene transfection. Surface-induced cell-specific recognition transfection achieved. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800412_s.pdf or from author. Please note: publisher not responsible content functionality any supporting supplied...
To comparatively investigate the cytotoxicities of nanomaterials in circulation, this study, three different types nanoparticles (NPs; mesoporous SiO2, Fe3O4, and TiO2) with diameters around 100 nm were synthesized. The morphologies, crystalline phases, zeta potentials those NPs characterized by scanning electron microscopy, X-ray diffraction potential measurement, respectively. Then, we investigated influences on biological functions endothelial cells, particular organelle cells. results...
Osteoporosis is the most common cause of fractures in middle-aged and elderly people. Fracture repair can be difficult due to decreased bone volume osteoporosis patients implants are often required. In this study, a slow-release system for microstructured titanium (Micro-Ti) was designed promote osteogenesis inhibit osteoclastogenesis. Firstly, Micro-Ti prepared on surfaces by dual acid etching. covered with naringin (NA), chitosan (CHI) gelatin (GEL) multilayers through layer technique,...
Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate adaptive immune responses. Soluble CD83 (sCD83), a secretion from various cell populations, especially MoDCs, is involved in negatively regulating response. We speculate sCD83 may be critical factor process PRRSV-coordinated macrophage polarization. In this study, we found that PAMs co-cultured with PRRSV-infected MoDCs inhibited M1 while enhancing M2...
Poor osteointegration and implant infection are two of the main causes that hinder success clinical implants. In order to enhance osteogenesis antibacterial activity titanium, BFP-1 GL13K peptides were immobilized on surface micro/nanostructured titanium using dopamine as a coupling mechanism. Successful construction surfaces was demonstrated by several material characterization methods including scanning electron microscopy (SEM), atomic force microscope (AFM), water contact angle...
To design titanium (Ti)-based biomaterials with controlled drug-releasing bioactive property, TiO2 nanotubes a diameter of approximately 110 nm was fabricated by electrochemical anodization. were then loaded naringin direct dropping and coated chitosan layers. The surface morphologies, chemical compositions wettability different substrates characterized field emission scanning electron microscopy, atomic force microscope, X-ray photoelectron spectroscopy contact angle measurement,...
To control the sustained release of melatonin and modulate osteogenic differentiation mesenchymal stem cells (MSCs), was firstly loaded onto TiO2 nanotubes by direct dropping method, then a multilayered film coated spin-assisted layer-by-layer technique, which composed chitosan (Chi) gelatin (Gel). Successful fabrication characterized field emission scanning electron microscopy, atomic force microscope, X-ray photoelectron spectroscopy contact angle measurement, respectively. The efficient...