A5068540257- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Diet and metabolism studies
- Dietary Effects on Health
- Physical Activity and Health
- Adipose Tissue and Metabolism
- Children's Physical and Motor Development
- Multimodal Machine Learning Applications
- Circadian rhythm and melatonin
- Renal and related cancers
- FOXO transcription factor regulation
- Cardiovascular and exercise physiology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Peptidase Inhibition and Analysis
- Advanced Image and Video Retrieval Techniques
- Eating Disorders and Behaviors
- Probiotics and Fermented Foods
- Thermoregulation and physiological responses
- Infection Control and Ventilation
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
Ruijin Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Nanchang University
2015-2020
Queen Mary University of London
2016
Premature ovarian insufficiency (POI) is an important cause of infertility and also menopausal symptoms, which greatly reduced the quality life for women. Hormone replacement therapy (HRT), as strategy, improved patients, however, role HRT in promoting fertility remains controversial. Therefore, seeking optimal regime POI becomes more urgent. In this study, we established model induced by CTX BUS utilized bone marrow derived mesenchymal stem cells (BM-MSCs) transplantation to treat POI. We...
Time-restricted feeding (TRF) has been recently reported as an effective dietary intervention for losing body weight, implying a negative energy balance, without restricting nutrient intake. However, the detailed balance alteration caused by TRF remains unclear. This study was randomized controlled clinical trial using within-subject cross-over design. Twelve healthy, normal-weighted volunteers (age: 24 ± 2.3 years; BMI: 21.9 1.71 kg/m2; 7 females) were studied under rigorous control calorie...
This randomized crossover trial evaluates the cardiopulmonary effects of extended use N95 mask during daily life.
Abstract Aims The adverse effects of sedentary behavior on obesity and chronic diseases are well established. However, the prevalence has increased, with only a minority individuals meeting recommended physical activity guidelines. This study aimed to investigate whether habitual leg shaking, traditionally considered unfavorable, could serve as an effective strategy improve energy metabolism. Materials Methods A randomized crossover was conducted, involving 15 participants (mean [SD] age,...
The Notch signalling pathway in the mammalian ovary regulates granulosa cell proliferation. However, effects of on steroidogenesis are unclear. In this study we cultured mouse ovarian cells from preantral follicles invitro and observed effect through overexpression, knockdown inhibition signalling. Activation decreased progesterone oestrogen secretion. contrast, increased production oestrogen. Expression genes for steroidogenic-related enzymes, including 3β-hydroxysteroid dehydrogenase, p450...
Abstract Prolyl oligopeptidase (POP), one of the most widely distributed serine endopeptidases, is highly expressed in ovaries. However, physiological role POP ovaries not clear. In this study, we investigated significance corpus luteum. Murine luteal cells were cultured vitro and treated with a selective inhibitor, (2 S )‐1[[(2 )‐1‐(1‐oxo‐4‐phenylbutyl)‐2‐pyrrolidinyl carbonyl]‐2‐pyrrolidinecarbonitrile (KYP‐2047). We found that KYP‐2047 treatment decreased progesterone secretion. contrast,...
This study examines the energy expenditure and physiological responses associated with short-term quadrupedal locomotion compared to bipedal walking in humans. It aims support evolutionary theory explore locomotion's potential for enhancing fitness health. In a randomized crossover design, twelve participants performed on treadmill at identical speeds. Physiological responses, including expenditure, carbohydrate oxidation rates, respiratory rate, heart were measured during both forms....
LncPrep+96kb is a novel long noncoding RNA (lncRNA) expressed in murine granulosa cells with two transcripts that are 2.2 kb and 2.8 length. However, the potential roles of lncPrep+96kb remain poorly understood. In this study, we investigated effect transcript on through overexpression knockdown kb. We found inhibited aromatase expression estradiol production. Endothelial differentiation-related factor 1(EDF1) an evolutionarily conserved transcriptional coactivator. EDF1 The...