A5100391636- Chemotherapy-induced cardiotoxicity and mitigation
- Lipoproteins and Cardiovascular Health
- Cancer-related gene regulation
- Electron Spin Resonance Studies
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Lipid metabolism and disorders
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
- Cardiac Fibrosis and Remodeling
- Microtubule and mitosis dynamics
- Micro and Nano Robotics
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Testicular diseases and treatments
- RNA Research and Splicing
- Venous Thromboembolism Diagnosis and Management
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
Guangxi Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2025
University of Science and Technology Beijing
2022-2025
Ningbo University
2022-2025
Ningbo First Hospital
2021-2024
Ningbo University Affiliated Hospital
2024
Zhejiang University
2021-2023
Ningbo No.6 Hospital
2021-2022
Traditional virtual screening methods need to explore expanse and vast chemical spaces be based on existing libraries. With the development of deep learning techniques for de novo generation molecules, also known as inverse molecular design, increasingly widespread application various types algorithms has led revolutionary changes in research. In particular, emergence a novel natural language processing (NLP) architecture called transformer improved state-of-the-art performance AI...
Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages act important roles during AS pathological process through regulating inflammation. Modification novel N(6)-methyladenine (m6A) RNA reported to be associated with AS, but its role in largely unknown. The aim this study was investigate mechanism m6A modification inflammation triggered by oxidized low-density lipoprotein (oxLDL) AS.RAW264.7 macrophage cells were stimulated 40 μg/ml ox-LDL, Dot blot,...
HIV and HBV infection are both serious public health challenges. There more than approximately 4 million patients coinfected with worldwide, 5% to 15% of those infected HBV. Disease progression is rapid in coinfection, which significantly increases the likelihood progressing from chronic hepatitis cirrhosis, end-stage liver disease, hepatocellular carcinoma. treatment complicated by drug interactions, antiretroviral (ARV) hepatotoxicity, HBV-related immune reconditioning inflammatory...
Abstract Previous studies have reported that visfatin can regulate macrophage polarisation, which has been demonstrated to participate in cardiac remodelling. The aims of this study were investigate whether participates transverse aortic constriction (TAC)‐induced remodelling by regulating polarisation. First, TAC surgery and angiotensin II (Ang II) infusion used establish a mouse model, expression was measured, the results showed or Ang increased serum heart mice, phenylephrine hydrogen...
Abstract — Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages play important roles in atherosclerosis. DExH-Box helicase 9 (DHX9), as a member DExD/H-box RNA superfamily II, identified an autoantigen sera systemic lupus erythematosus patients to trigger inflammation. The aim this study was investigate whether DHX9 involved AS development, especially macrophages-mediated-inflammatory responses. We find that expression significantly increased oxLDL or...
Interleukin-5 (IL-5) has been reported to be involved in cardiovascular diseases, such as atherosclerosis and cardiac injury. This study aimed investigate the effects of IL-5 on remodelling. Mice were infused with angiotensin II (Ang II), expression source analysed. The results showed that was time- dose-dependently decreased after Ang infusion, mainly derived from macrophages. Additionally, IL-5-knockout (IL-5-/-) mice used observe knockout II-induced We found significantly increased...
Background. Visfatin is an adipocytokine that has been demonstrated to be involved in cardiovascular diseases. This study aims at determining the role of visfatin sepsis-induced cardiac injury and identify its possible mechanisms. Methods. Dynamic changes expression mice with lipopolysaccharide- (LPS-) induced septicemia were measured. Additionally, pretreated further administered LPS observe effects on injury. Finally, septic also JSH-23 investigate whether regulates via NF-κB p65 pathway....
Grb2-associated binding protein 1 (Gab1), an intracellular scaffolding adaptor, was involved in several cardiovascular diseases. However, the role of Gab1 doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. The present study investigated whether protected against DOX-induced and underlying mechanism. We overexpressed hearts using adeno-associated virus 9 system through tail vein injection. C57BL/6 mice were subjected to DOX (15 mg/kg/d, i.p.) generate cardiotoxicity....
Epigenetics, referring to genetic modifications that change gene expression, but which are not encoded in DNA, has been shown be related oncology, with the potential influence associated treatments. As such, epigenetic drugs comprise an important new field cancer therapy; however, drug development is a high-cost and time-consuming procedure. Different modifications, such as mutations DNA methyltransferase somatic core histone genes lead global loss of have innumerable relationships. In this...
Heart failure is a group of syndromes caused by various cardiac structural or functional disorders leading to impaired ventricular filling and (or) ejection capacity. Because decreased systolic function function, the amount output cannot meet body's metabolic needs; organ tissue blood perfusion insufficient; at same time, pulmonary circulation systemic congestion; clinical manifestations are mainly dyspnea weakness but restricted physical activity edema. Treatment disease should include...
Abstract Background Changes in circadian rhythm are related to various diseases, such as immune system diseases and cardiovascular diseases. The PERIOD3 (PER3) clock gene is one of the most important genes regulation system. Our goal was evaluate possible association between PER3 rs228729 ( T / C ) polymorphism or rs2797685 clopidogrel resistance (CR) study impact clinical baseline data on resistance. Methods polymorphisms were assessed 156 patients with (72) without (84) CR. Blood samples...
Abstract Background Due to the loss of responsiveness insulin, diabetes mellitus (DM) patients develop increased platelet reactivity and reduced response antiplatelet agents. Nevertheless, relationship between single‐nucleotide polymorphisms (SNP) signal pathway gene insulin secretion effect clopidogrel is elusive. Methods Blood samples were collected from administered with dual‐antiplatelet therapy (clopidogrel, 75 mg, once daily aspirin, 100 daily) after 5 days completed test within 4 h....
Abstract Background Familial hypercholesterolemia (FH) is a prevalent hereditary disease that can cause aberrant cholesterol metabolism. In this study, we confirmed c.415G > A in LDLR , an FH-related gene, deleterious mutation FH by silico analysis and functional experiments. Methods The proband his family were evaluated the diagnostic criteria of Dutch Lipid Clinic Network. Whole-exome Sanger sequencing used to explore validate mutations. analyses evaluate pathogenicity candidate its...
Abstract Background Familial hypercholesterolemia (FH) is a prevalent hereditary disease that can cause aberrant cholesterol metabolism. In this study, we confirmed c.415G > A in low-density lipoprotein receptor ( LDLR ), an FH-related gene, pathogenic variant FH by silico analysis and functional experiments. Methods The proband his family were evaluated using the diagnostic criteria of Dutch Lipid Clinic Network. Whole-exome Sanger sequencing used to explore validate variants. analyses...
Familial hypercholesterolemia (FH) is an inherited disorder with markedly elevated low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. Although many mutations have been reported in FH, only a few identified as pathogenic mutations. This study aimed to confirm the pathogenicity of LDL receptor (LDLR) c.2160delC variant FH.In this study, proband her family members were systematically investigated, pedigree map was drawn. High-throughput whole-exome...
Abstract Atherosclerosis (AS) is the main cause of cerebrovascular diseases, and macrophages act important roles during AS pathological process through regulating inflammation. Modification novel N(6)-methyladenine (m6A) RNA reported to be associated with atherosclerosis, but its role in largely unknown. The aim this study was investigate mechanism m6A modification oxidised low-density lipoprotein (oxLDL) triggered inflammation AS. Dot blot, Immunoprecipitation, western Rip Chip experiments...
Abstract Background Aspirin resistance (AR) results in major adverse cardiovascular events, and DNA methylation might participate the regulation of this pathological process. Methods In present study, a sum 35 patients with AR non‐AR (NAR) controls were enrolled. Samples from 5 NAR evaluated an 850 BeadChip assay, another 30 versus to validate differentially methylated CpG loci (DML). Then, qRT‐PCR was used investigate target mRNA expression genes at loci. Finally, Gene Ontology (GO) as well...
Resistin is closely related to cardiovascular diseases, and this study aimed at examining the role of resistin in doxorubicin- (DOX-) induced cardiac injury. First, 48 mice were divided into 2 groups treated with saline or DOX, expression different time points was examined (N = 24). A total 40 pretreated antiresistin neutralizing antibody (nAb) isotype IgG for 1 hour further administered DOX 5 days. The 4 groups: saline-IgG, saline-nAb, DOX-IgG, DOX-nAb 10). Cardiac injury, cardiomyocyte...