A5084926688- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Signaling Pathways in Disease
- Heat shock proteins research
- Cardiac Imaging and Diagnostics
- Circular RNAs in diseases
- GDF15 and Related Biomarkers
- Thermal Regulation in Medicine
- Takotsubo Cardiomyopathy and Associated Phenomena
- Viral Infectious Diseases and Gene Expression in Insects
- thermodynamics and calorimetric analyses
- Air Quality and Health Impacts
- Anesthesia and Neurotoxicity Research
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Redox biology and oxidative stress
- Studies on Chitinases and Chitosanases
- Sleep and Work-Related Fatigue
- Biomarkers in Disease Mechanisms
- Cell death mechanisms and regulation
- Human Health and Disease
- NF-κB Signaling Pathways
- Chemotherapy-induced cardiotoxicity and mitigation
Hainan Medical University
2024-2025
University of South China
2020-2024
Hengyang Academy of Agricultural Sciences
2021-2023
Wuhan University
2016-2018
Renmin Hospital of Wuhan University
2016-2018
Guangxi University
2016
Jiangsu University of Technology
2016
To investigate the current situation of hearing loss and associations occupational noise exposure with in petrochemical enterprise workers. This was a cross-sectional study that employed cluster sampling methods, 951 workers aged 20–59 years from were included between June December 2022. The subjects underwent health status surveys examinations. assess level loss, logistic regression model used to calculate odds ratios (ORs) 95% confidence intervals (CIs). A total participants (837 male 114...
Myeloid differentiation protein 1 (MD1) has been implicated in numerous pathophysiological processes, including immune regulation, obesity, insulin resistance, and inflammation. However, the role of MD1 cardiac remodelling remains incompletely understood. We used MD1-knockout (KO) mice their wild-type littermates to determine functional significance regulation aortic banding (AB)-induced left ventricular (LV) structural electrical its underlying mechanisms. After 4 weeks AB, MD1-KO hearts...
Abstract Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. Previous studies showed that MD-1 may be restricted the immune system. In this study, we demonstrated for first time was highly expressed both human and animal hearts. We also discovered cardiac-specific overexpression of significantly attenuated pressure overload-induced cardiac hypertrophy, fibrosis,...
MOTS-c, a mitochondrial-derived peptide (MDP), has been shown to have multiple biological activities such as antioxidation, anti-inflammation, and anti-apoptosis properties. In the present study, we aimed at evaluating therapeutic effect of MOTS-c in an animal model heart failure. The failure mouse was made by transverse aortic constriction (TAC) operations. administrated subcutaneously using osmotic pump. At end experiment, cardiac function evaluated echocardiography, tissues were subjected...
Abstract Background Downregulated expression of cold-inducible RNA binding protein (CIRP), a stress-response protein, has been demonstrated in the hearts patients with heart failure (HF). However, whether CIRP plays critical role pathogenesis HF remains unknown. Zr17-2 is recently identified agonist, which can enhance hearts. Herein, we evaluated effects zr17-2 on development rat model myocardial infarction (MI). Methods Male SD rats were pretreated agonist or vehicle saline for 6...
Atherosclerosis (AS) is the most common inducer of cardiovascular diseases, and resveratrol (RSV) has played a protective function in endothelial injury AS. This study was to explore molecular mechanism RSV oxidized low-density lipoprotein (ox-LDL)-mediated dysfunction.Circ_0091822, microRNA-106b-5p (miR-106b-5p) or toll-like receptor (TLR4) levels were examined using reverse transcription-quantitative polymerase chain reaction assay. Cell viability detected via Counting Kit-8 assay...
<title>Abstract</title> <bold>Objective:</bold> The study aimed to examine the association between allergic rhinitis and early-life indoor environmental exposure in preschool children Haikou City, providing a scientific theoretical basis for prevention of this population. <bold>Methods:</bold> In January 2021, we conducted China Child Home Health (CCHH) using case-control approach with 1090 Hainan Province, including 218 cases 872 controls. included baseline demographic information,...
Interleukin-5 (IL-5) has been reported to be involved in cardiovascular diseases, such as atherosclerosis and cardiac injury. This study aimed investigate the effects of IL-5 on remodelling. Mice were infused with angiotensin II (Ang II), expression source analysed. The results showed that was time- dose-dependently decreased after Ang infusion, mainly derived from macrophages. Additionally, IL-5-knockout (IL-5-/-) mice used observe knockout II-induced We found significantly increased...
To investigate the mediating effect of oxidative stress on relationships between low-concentration benzene, toluene, and xylene (BTX) exposure blood pressure in workers. A cross-sectional study involving 841 workers from a petroleum refining enterprise Hainan, China, was conducted. Among workers, 615 were exposed to BTX, 216 control group. S-phenylmercapturic acid (S-PMA), hippuric (HA), methyl (MHA, including three isomers 2-MHA, 3-MHA, 4-MHA) measured urine via high-performance liquid...
The study aimed to examine the relationship between occupational factors and sleep disorders among employees in petrochemical enterprises.
With the WiFi becoming more and popular over last few years, study on technology of indoor positioning based is given attention. Being specific to problem that not all clustered reference points(RPs) traditional clustering algorithm have geometric proximity in positioning, this paper puts forward affinity propagation presentation(AP) which bases combination geometry received signal strength (RSS). different from algorithm, kind can endow RPs with geometrical RSS corresponding weight...
Myeloid differentiation protein 1 (MD1), a negative regulator of toll-like receptor 4 (TLR4), is widely expressed in the heart. Recent studies have shown that MD1 plays an important role cardiac remodelling. However, effects and potential mechanisms underlying MD1-mediated atrial remodelling diabetic cardiomyopathy (DCM) remain unclear. Therefore, this study was designed to explore DCM-related remodelling.MD1 knockout (MD1-KO) mice wild-type (WT) littermates were injected with streptozotocin...
Abstract Aims Myeloid differentiation protein 1 (MD1) was shown to ameliorate pressure overload‐induced cardiac hypertrophy and fibrosis by negatively regulating the MEK–ERK1/2 NF‐κB pathways. However, whether MD1 modulates function Akt pathway mediates benefits of in remodelling remain unclear. Methods Results Male cardiac‐specific transgenic (MD1‐TG) mice, MD1‐knockout (KO) mice wild‐type (WT) littermates aged 8–10 weeks were subjected sham operation aortic banding (AB) for 4 weeks. Then,...