A5100621707- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Synthesis and Biological Evaluation
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Catalytic Alkyne Reactions
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Synthesis of Indole Derivatives
- Advanced Synthetic Organic Chemistry
- Synthesis and bioactivity of alkaloids
- Synthesis of heterocyclic compounds
- Copper-based nanomaterials and applications
- Carbon dioxide utilization in catalysis
- Click Chemistry and Applications
- Catalytic Processes in Materials Science
- Phenothiazines and Benzothiazines Synthesis and Activities
- Signaling Pathways in Disease
Oregon Health & Science University
2024-2025
Ningbo University
2023-2024
Anhui Normal University
2017-2024
China Pharmaceutical University
2012-2023
Ningbo Medical Center Lihuili Hospital
2023
Ningbo First Hospital
2023
Chengdu Medical College
2022
Nantong University
2022
Anhui Jianzhu University
2022
Shaanxi Provincial Land Engineering Construction Group
2021
Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes. As service to our authors and readers, this journal provides supporting information supplied the authors. Such materials peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed...
A Ru–Co bimetallic catalyst was well demonstrated in benzene oxidation, and the reaction mechanism studied.
As the largest global carbon pool system, terrestrial ecosystems have an important role to maintain stability of ecosystems. Human activities affect structural changes in ground surface and interfere with ecosystem evolution, consequently, stock is changed region. Therefore, forecasting future under different land use scenarios has research implications for promoting stable evolution cycling This study conducted data from 2000 2020, incorporates Patch-generating Land Use Simulation model...
Abstract A novel procedure for the synthesis of C2‐diversified oxazoles, through palladium‐catalyzed imidoylative cyclization α‐isocyanoacetamides with aryl, vinyl, alkynyl halides, or triflates, was developed. Migratory insertion isocyanide into a C ‐palladium(II) intermediate in cascade process also realized, generating alkyl‐substituted oxazoles. Therefore, oxazoles functionalized at C2 position sp, sp 2 , and 3 hybridized carbon atoms are accessible by applying this method.
A new strategy for the construction of phenanthridine and isoquinoline scaffolds, starting from arenes containing a pending isocyanide moiety under palladium catalysis, has been developed. This process involves sequential intermolecular insertion to an aryl palladium(II) intermediate intramolecular aromatic C-H activation as key steps. Alkyl lacking β-hydrogen is also applicable this reaction, generating unique bisheterocyclic scaffolds with three C-C bonds being formed consecutively.
Efficient access to multiple functionalized allenes via a three component 1,4-alkylcyanation of enynes with cyclic alcohol derivatives in the presence trimethylsilyl cyanide (TMSCN) under copper/photoredox dual catalysis has been developed. Both easily transformable aldehyde and cyano groups were introduced tetra-substituted through light-induced C–C bond cleavage butanol pentanol derivatives. The reactions proceeded smoothly mild conditions broad functional tolerance.
Adding a very small amount of Pt entities (0.01–0.03 wt%) onto the Au surface Au/TiO2 catalyst is found to be an efficient approach improve catalytic activity for hydrogenation p-chloronitrobenzene (p-CNB), without loss selectivity towards p-chloroaniline (p-CAN). The effect amount, reaction temperature, H2 pressure and time on p-CNB was studied with 0.02wt%Pt–0.5wt%Au/TiO2 (Pt0.0002–Au0.005/TiO2). p-CAN could up 100% at complete conversion temperatures or below 333 K. also exhibited perfect...
An efficient palladium-catalyzed enantioselective isocyanide insertion/desymmetrizing C(sp2)–H bond activation reaction allowed by a SPINOL-derived phosphoramidite ligand was developed. 3,4-Dihydroisoquinolines containing C3 quaternary stereogenic centers were obtained in high yields with good enantioselectivity under mild conditions.
Abstract Pyrroles, ubiquitous bioactive heterocycles in nature, are readily prepared via a palladium‐catalyzed oxidative annulation of cyclic trans ‐enamines to various internal alkynes the absence directing group. magnified image
A general and practical amidoalkylation reaction, using N,N-dialkylamides in the presence of potassium persulfate as sole reagent, has been developed. 2-Amidoalkylated benzothiazole- 3-amidoalkyl-substituted indolinone derivatives were obtained by benzothiazoles N-aryl-N-methyl-methacrylamides substrates, respectively. The transformation proceeded smoothly through amidoalkyl radical intermediates that trapped or activated alkenes.
A palladium-catalyzed imidoylative cyclization of ethyl-3-(1H-indol-3-yl)-2-isocyanopropanoates, derived from readily available tryptophan, to afford β-carboline derivatives has been developed. The reaction proceeds smoothly under mild conditions through sequential isocyanide insertion, intramolecular C–H imidoylation, and aerobic dehydrogenative aromatization with a decent substrate scope. This method provides general approach for the synthesis molecules containing fragment.
Efficient access to cyclic imine-containing indoline derivatives through palladium-catalysed dearomative aryl/cycloimidoylation of indoles using functionalized isocyanides has been developed.
A general and robust strategy for the synthesis of phosphonylated spirocyclic indolines has been developed through Cp2Fe-catalyzed electrochemical dearomaztizaion indoles, which proven challenging to achieve via chemical oxidants. range 3,3-spiroindolines were obtained in moderate good yields with excellent diastereoselectivities. The synthetic application was further illustrated by its easy scalability antitumor activity product.
Efficient access to fluoroalkyl indoles and isoquinolones through palladium-catalysed aryl/monofluoroalkylation of allenamides has been developed.
Proteins regulate biological functions through the formation of distinct protein complexes. Identification and characterization these protein–protein interactions are critical to deciphering their mechanism action. Different antibody-based or cross-linking-based methods have been developed identify interactions. However, require genetic engineering other means disrupt native environments. To circumvent this limitation, we introduce here SMAP3-ID (small-molecule-assisted identification...
A tunable route to both isomers of benzo[d]imidazothiazole has been developed through copper-promoted cycloaddition α-methylenyl isocyanides with benzothiazoles. When the C2 position benzothiazole is linked a C–H or C–C bond, benzo[d]imidazo[2,1-b]thiazoles are obtained novel rearrangement via C–S bond cleavage and formation new bond. 2-chloro- 2-bromobenzothiazoles used under same reaction conditions, isomeric benzo[d]imidazo[5,1-b]thiazoles formed selectively. These reactions proceed...
Efficient access to five- seven-membered cyclic ketoimines, through palladium-catalyzed intramolecular imidoylative Heck reaction of alkene-containing isocyanides, has been developed. Consecutive isocyanide and alkene insertion into aryl or alkyl Pd(II) intermediates takes place in this process. No byproduct derived from monoinsertion reversed sequence is detected.
A novel one-step synthesis of both symmetric and unsymmetric 2,2′-bisoxazoles starting from simple acyclic α-isocyanoacetamides was achieved.
Antibiotic contamination has become a serious global problem due to abuse and misuse. Therefore, it is important develop an efficient detection method monitor the rational use of antibiotics. In this study, fluorescent gold nanoclusters with 11-mercaptoundecanoic acid as ligands (MUA-AuNCs) were synthesized by one-step firstly. Rare earth ions (Re3+) can enhance fluorescence MUA-AuNCs through inducing aggregation MUA-AuNCs, but antibiotics decrease Re3+-MUA-AuNCs different degrees...
Wohlbekannte Strukturmotive aus der medizinischen Chemie, die Benzazepine, können glatt durch palladiumkatalysierte oxidative Cycloaddition von Isatinen mit verschiedenen Alkinen aufgebaut werden. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed...
A palladium-catalysed construction of spiroindolines through dearomative spirocyclization 3-(2-isocyanoethyl)indoles has been developed. 2'-Aryl-, vinyl-, and alkyl-substituted could be accessed under mild conditions with excellent functional group tolerance. C1-tethered oxindole- indole-spiroindoline bisheterocycles were generated in high yields via alkene/allene insertion an imidoylative cascade. Additionally, a tandem dearomatization two different indoles was realized...