A5101671984- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Renal and related cancers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- PARP inhibition in cancer therapy
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Cardiac Ischemia and Reperfusion
- Prostate Cancer Treatment and Research
- Tuberous Sclerosis Complex Research
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Sexuality, Behavior, and Technology
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Planarian Biology and Electrostimulation
- Antimicrobial Peptides and Activities
Nanchang University
2009-2024
First Affiliated Hospital of Nanchang University
2017-2024
Affiliated Hospital of Guizhou Medical University
2023
Kowloon Hospital
2022
Suzhou Kowloon Hospital
2022
Shanxi Medical University
2022
Minzu University of China
2021
Zhejiang Academy of Medical Sciences
2019
Shantou University
2018
Shantou University Medical College
2018
Background Tislelizumab is an investigational, humanized, IgG4 monoclonal antibody with high affinity and binding specificity for programmed cell death-1 (PD-1) that was engineered to minimize FcγR on macrophages in order abrogate antibody-dependent phagocytosis, a mechanism of T-cell clearance potential resistance anti-PD-1 therapy. Methods The purpose this phase 1/2, open-label, non-comparative study examine the safety, tolerability, antitumor activity tislelizumab adult (≥18 years)...
To explore characteristics of urinary stone composition in China, and determine the effects gender, age, body mass index (BMI), location, geographical region on composition.We prospectively used Fourier-transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals seven areas between 1 June 2010 31 May 2015. Chi-squared tests logistic regression analyses were associations BMI, region.The most common constituents were:...
•Toripalimab plus axitinib provided significantly better PFS than sunitinib as a first-line treatment for advanced RCC.•A higher ORR was found in patients who received toripalimab those sunitinib.•The combination of generally well tolerated.•No new safety signals were identified the outside known profile or axitinib. BackgroundImmune checkpoint inhibitors with tyrosine kinase are standard treatments clear cell renal carcinoma (RCC). This phase III RENOTORCH study compared efficacy and versus...
Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to I/R injury. Silent information regulator 1(SIRT1) not only interacts with inhibited by Egr-1, but also downregulates reactive oxygen species (ROS) via Forkhead box O1(FOXO1)/manganese superoxide dismutase (Mn-SOD) signaling pathway. N-n-butyl haloperidol iodide (F2), new patented compound, protects myocardium...
Background: Transmembrane 25(TMEM25) stands out as a potential prognostic biomarker and therapeutic target in the realm of cancer, yet its precise mechanism action within clear cell renal carcinoma (ccRCC) remains unclear. Materials Methods: Gene expression data clinically relevant information extracted from The Cancer Genome Atlas (TCGA) omnibus (GEO) databases unveil patterns TMEM25 carcinoma, which reveals diagnostic significance. protein is available via Human Protein (HPA) database....
Background: Clear cell renal carcinoma(ccRCC) is one of the most common malignancies. However, there are still many barriers to its underlying causes, early diagnostic techniques and therapeutic approaches. Materials Methods: The Cancer Genome Atlas (TCGA)- Kidney clear (KIRC) cohort differentially analysed liquid-liquid phase separation (LLPS)-related genes from DrLLPS website. Univariate multivariate Cox regression analyses LASSO were used construct prognostic models. E-MTAB-1980 was for...
Long noncoding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Gastric adenocarcinoma-associated, positive CD44 regulator, long intergenic RNA (GAPLINC) is a recently identified lncRNA that can actively participate in tumorigenesis various cancers. Here, we investigated functional roles mechanism GAPLINC renal cell carcinoma (RCC) development.Differentially expressed lncRNAs between RCC tissues normal kidney were detected by using microarray technique....
Given that myc was known to be a cancer-causing gene in several cancers including kidney renal clear cell carcinoma (KIRC). We aimed construct myc-regulated genes (MRGs)-based prognostic signature. obtained the mRNA expression and clinical data of KIRC from The Cancer Genome Atlas (TCGA) database MRGs Molecular Signature Database (MSigDB). Then, signature consisting 8 (IRF9, UBE2C, YBX3, CDKN2B, CKAP2L, CYFIP2, FBLN5, PDLIM7) developed by differential analysis, cox regression least absolute...
Cancer is still a leading of cause death worldwide. Among the bio-therapy strategies for cancer, vaccinia virus (VV) has been widely used as an expression vector because its potent oncolytic activities in addition to large capacity insertion foreign genes and excellent safety records. In present study, novel recombinant VV, VV-HBD2-lac
Abstract Background RNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function clear cell renal carcinoma (ccRCC) is still not well understood. Methods The expression matrix was extracted from the Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets analyzed for diagnostic prognostic value. mRNA detected by quantitative polymerase chain reaction (qPCR) ccRCC patients cancer lines. Wound healing assay,...
Background: Multiple studies have identified that E2F transcriptions act as important regulators for the tumorigenesis and progression of several human cancers. However, little is known about function E2Fs in clear cell renal carcinoma (ccRCC). Methods: We firstly investigated expression levels, genetic alteration, biological patients with ccRCC connections between immune infiltration overall survivals levels based on UALCAN, The Cancer Genome Atlas database, Gene Expression Profiling...
Objective: To compare the safety and effectiveness of robot-assisted partial nephrectomy (RAPN) vs laparoscopic (LPN) in treatment central renal angiomyolipomas (AMLs). Methods: We retrospectively analyzed clinical data 103 patients who were treated with either RAPN or LPN for AMLs between January 2017 June 2022. Propensity scores matched according to sex, age, laterality, body mass index, symptoms, diameter tumor, location tumor distribution, R.E.N.A.L score, preoperative hemoglobin, serum...
Foot electrical stimulation (FES) has been considered as a classic stressor that can disturb homeostasis. Acute anemia was observed in the model induced by FES. The aim of this study to explore role inflammatory cytokines underlying acute and gastrointestinal (GI) mucosal injury Twenty-four male Kunming mice (20 ± 2 g) were randomly divided into control group experimental group. placed footshock chamber generate 0.5 mA impulse periodically for h. After process, red blood cell count,...
DLEU2 is a long noncoding RNA considered important in the progression of many cancers. However, correlations between and kidney renal clear cell carcinoma (KIRC) liver hepatocellular (LIHC) have rarely been reported.We first analysed expression across cancers correlation clinical features KIRC LIHC by using "ggplot2" package R searched Oncomine database Timer website platform. We verified GEO dataset (GSE105261 GSE45267). Receiver operating characteristic (ROC) curves were drawn "pROC"...
SLFN11 has been found to regulate the development and progression of a variety cancers is associated with drug therapy, while its role in clear cell renal carcinoma (ccRCC) remains unclear; therefore, aim this study was investigate expression ccRCC patients correlations clinicopathological immunological features.Gene profiles information were downloaded from TCGA database. Microarrays GEO database used as validation set for expression, which experimentally verified cancer lines by...
Aim. To evaluate the urinary continence (UC), erectile function, and cancer control obtained following robot-assisted radical prostatectomy (RARP) laparoscopic (LRP) for intermediate- high-risk localized prostate (PCa). Materials Methods. 232 patients bearing PCa were enrolled in this study. Perioperative, functional, oncological outcomes analyzed after applying propensity score matched method. Results. Within cohort, RARP group was corrected with a significantly shorter mean operative time...
Background. GRAM structural domain-containing protein 1A (GRAMD1A) is upregulated in a variety of human cancer tissues and closely associated with tumourigenesis progression. Methods. Patient RNA-sequencing data clinicopathological information were obtained from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets. expression GRAMD1A kidney cell lines KIRC patients was analysed by quantitative polymerase chain reaction (qPCR). Receiver Operator Characteristic (ROC) curves,...
RNA binding proteins (RBPs) play significant roles in the development of tumors. However, a comprehensive analysis biological functions RBPs clear cell renal carcinoma (ccRCC) has not been performed. Our study aimed to construct an RBP-related risk model for prognosis prediction ccRCC patients. First, sequencing data were downloaded from The Cancer Genome Atlas (TCGA) database. Three RBP genes (EIF4A1, CARS, and RPL22L1) validated as prognosis-related hub by univariate multivariate Cox...
SNHG10 is a long non-coding RNA (lncRNA) found to be overexpressed in multiple human cancers including prostate cancer (PC). However, the underlying mechanisms of driving progression PC remains unclear. In this study, we investigated role and that expression was significantly increased datasets extracted from The Cancer Genome Atlas. Increased related advanced clinical parameters. Receiver operating curve analysis revealed significant diagnostic ability (AUC = 0.805). addition, immune...
Background: Although DBT is strongly associated with human tumorigenesis and progression through a variety of pathways, the role in clear cell renal carcinoma (ccRCC) has not been well established. Materials methods: The Cancer Genome Atlas (TCGA)-Kidney (KIRC) databset provides RNA sequencing data clinicopathological information on ccRCC. Gene Expression Omnibus (GEO) database was used to validate expression levels, qPCR examine cancer lines ccRCC tissue samples from our centre. In...