Abstract The challenge in treating diabetic foot infections caused by drug‐resistant bacteria is rapidly eradicating and accelerating wound healing. NIR‐II‐induced photothermal therapy (PTT) offers notable advantages over conventional treatments, such as broad‐spectrum bactericidal efficacy, better penetration depth biological tissues, higher skin tolerance thresholds, making it particularly suitable for addressing infections. Herein, found that NIR‐II dye IR26 exhibited good effects but...

Estrogen receptor (ER)-negative breast cancer is heterogeneous, and the biology of this disease has remained poorly understood. Molecular apocrine a subtype ER-negative that characterized by overexpression steroid-response genes such as AR high rate ErbB2 amplification. In study, we have identified positive feedback loop between extracellular signal-regulated kinase (ERK) signaling pathways in molecular cancer. process, regulates ERK phosphorylation activity. addition, inhibition results...

Background Extrafusal muscle fibers of human striated skeletal muscles are known to have a uniform innervation pattern. Motor endplates (MEP) the "en plaque" type located near center and distributed within in narrow band. The aim this study was evaluate pattern facial compare it with that muscles. Methods Ten from 11 cadavers were dissected, nerve entrance points located, dimensions measured. All stained toto for MEPs using Acetylcholinesterase (AChE) examined under microscope determine...

As an important member of T cytotoxic pathway-related genes, CD8a molecule (CD8A) may be a useful biomarker immunotherapeutic response and immune cell infiltration. We aimed to investigate the clinical predictive value CD8A in prognosis tumor microenvironment (TME) preoperatively predict expression using radiogenomics bladder cancer (BCa). Among 12 was novel protective gene had highest correlations with cells Macrophages M1 BCa. In advanced patients treated immunotherapy, low associated...

Fresh products are characterized by a certain deterioration rate, and the fresh supply chain typically relies on third-party cold logistics companies (3PLs) for transportation. This study constructs composed of supplier, retailer, company, where shipping costs borne either supplier or retailer. The bearer considers whether to adopt blockchain technology enhance transparency improve consumers’ perceived value. Using game theory, paper attempts explore who should bear (supplier retailer),...

Abstract Introduction Estrogen receptor-negative (ER-) breast cancer is a heterogeneous disease with limited therapeutic options. The molecular apocrine subtype constitutes 50% of ER-tumors and characterized by overexpression steroid response genes including androgen receptor (AR). We have recently identified positive feedback loop between the AR extracellular signal-regulated kinase (ERK) signaling pathways in subtype. In this loop, regulates ERK phosphorylation through mediation ErbB2 and,...

Background Alzheimer’s disease (AD) is the most common cause of dementia and cognitive decline, while its pathological mechanism remains unclear. Tauopathies one widely accepted hypotheses. In this study, molecular network was established expression pattern core gene analyzed, confirming that dysfunction protein folding degradation critical factors for AD. Methods This study analyzed 9 normal people 22 AD patients’ microarray data obtained from GSE1297 in Gene Expression Omnibus (GEO)...

Abstract: Mulberry fruits have different chemical compositions because of cultivar variation. In this study, polyphenol profile and volatile composition alcoholic beverages produced from mulberries Da 10, Hongguo 2 hao, 1 hao were investigated. Statistically significant differences detected in the analyzed beverage samples. The 10 possessed highest content total phenols, flavonoids, anthocyanins, which was determined by spectrophotometry analysis, contrarily showing lowest. Phenolic acids...

// Kai-Dun Tang 1 , Boris M. Holzapfel Ji Liu Terence Kin-Wah Lee 2 Stephanie Ma 3 Lidija Jovanovic Jiyuan An Pamela J. Russell Judith A. Clements Dietmar W. Hutmacher and Ming-Tat Ling Australian Prostate Cancer Research Centre-Queensland Institute of Health Biomedical Innovation, Queensland University Technology Translational Institute, Woolloongabba, Qld, Australia Department Pathology, Faculty Medicine, The Hong Kong, SAR, China Anatomy, Correspondence to: Ling, email: Keywords : Tie-2;...

Background: Transmembrane 25(TMEM25) stands out as a potential prognostic biomarker and therapeutic target in the realm of cancer, yet its precise mechanism action within clear cell renal carcinoma (ccRCC) remains unclear. Materials Methods: Gene expression data clinically relevant information extracted from The Cancer Genome Atlas (TCGA) omnibus (GEO) databases unveil patterns TMEM25 carcinoma, which reveals diagnostic significance. protein is available via Human Protein (HPA) database....

Abstract The relationship between metabolism and immune microenvironment remains to be studied in bladder cancer (BCa). We aimed construct a metabolic‐associated signature for prognostic prediction investigate its with the BCa. RNA expression of associated genes was obtained from combined data set including Cancer Genome Atlas, GSE48075, GSE13507 divide BCa patients into different clusters. A constructed using differentially expressed clusters validated IMvigor210 trial our center....

Inhibition of tumor cell migration is a treatment strategy for patients with colorectal cancer (CRC). SCF-dependent activation c-KIT responsible positive [c-KIT(+)] cells CRC. Drug resistance to Imatinib Mesylate (c-KIT inhibitor) has emerged. mTOR can induce autophagic degradation c-KIT. (+)-usnic acid [(+)-UA], isolated from lichens, two major functions including induction proton shuttle and targeting inhibition mTOR. To reduce hepatotoxicity, the concentration (+)-UA should be lower than...

Abstract Background RNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function clear cell renal carcinoma (ccRCC) is still not well understood. Methods The expression matrix was extracted from the Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets analyzed for diagnostic prognostic value. mRNA detected by quantitative polymerase chain reaction (qPCR) ccRCC patients cancer lines. Wound healing assay,...

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for initiation as well disease progression.Unfortunately, conventional therapies only effective in targeting the more differentiated and spare CSCs.Here, we report PSP, an active component extracted from mushroom Turkey tail (also known Coriolus versicolor), is CSCs.We found treatment of cell line PC-3 with PSP led to down-regulation CSC markers (CD133 CD44) a time dose-dependent manner.Meanwhile, not...

This paper presents a two-stage hybrid plasma catalyst system for toluene decomposition in air. It consists of dielectric barrier discharge reactor and Mn-based composite oxides catalysts. Experimental results show that removal efficiency was 10 % by only plasma, but 100 destruction as well 100% ozone achieved catalysis at specific energy density 28.8 J L−1. The catalytic produced the first stage is following order: NTP+ Mn-Co/Al > NTP + Mn-Ce/Al Mn-Ni/Al NTP. Compared to other catalysts...

BACKGROUND: Mico-volume semen freezing is essential and used popularly for fertility preservation of patients suffering cancer or undergoing male reproductive system related surgeries, other reasons that may risk potential in ART cycles. However, clinicians embryologists still face some unresolved technical theoretical issues about the frozen-thawed efficiency. OBJECTIVE: To choose appropriate method different volumes normal samples. MATERIALS AND METHODS: We investigated outcomes with (20...

The 'Dali' winter jujube was used as the test object. postharvest pathogens were isolated, purified and identified . pathogenicity determined by Koch's postulates. antibacterial activity of 34 types plant essential oils against with strong determined. findings indicated that a fungus isolated from diseased jujube, which marked DZ1. phylogenetic tree showed DZ1 strain had high relationship Fusarium oxysporum Among oils, basil, mustard, litsea cubeba cinnamon (1000μl/L) most significant effect...

Mechanical ventilation (MV) remains a cornerstone of critical care; however, its prolonged application can exacerbate lung injury, leading to ventilator-induced injury (VILI). Although previous studies have implicated ferroptosis in the pathogenesis VILI, underlying mechanisms remain unclear. This study investigated roles ferritinophagy subsequent VILI. Using C57BL/6J mice and MLE-12 cells, we established both vivo vitro models VILI cyclic stretching (CS)-induced cellular injury. We assessed...