A5015056054- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Treatment of Major Depression
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Machine Learning in Bioinformatics
- Immune Response and Inflammation
- Metabolism and Genetic Disorders
- RNA regulation and disease
- NF-κB Signaling Pathways
- Autoimmune and Inflammatory Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Health and Disease Prevention
Zhangzhou Municipal Hospital of Fujian Province
2018-2024
Fujian Medical University
2011-2024
Ningde Normal University
2024
Union Hospital
2011-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Guilin Medical University
2024
Fujian Institute of Microbiology
2019
Chongqing Medical University
2016
Second Affiliated Hospital of Chongqing Medical University
2016
Antisera were raised against a synthetic peptide corresponding to the carboxyl terminus of kappa-opioid receptor (KOR1). Specificity antisera was verified by staining COS-7 cells transfected with KOR1 and epitope-tagged cDNAs, recognition proteins on Western blots both brain tissue, absence tissue after preabsorption cognate peptide, strong correlation between distribution immunoreactivity that earlier ligand binding in situ hybridization studies. Results indicate neurons is targeted into...
Background and Purpose: EVT is a standard treatment for LVO in patients with an NIHSS score ?6, but its role mild stroke (NIHSS <6) remains uncertain. This study aims to explore the association between clinical outcomes stroke. Methods: non-randomized cohort prospectively enrolled consecutive at 35 comprehensive centers across 15 Chinese provinces from January 2020 December 2023. Patients were categorized into pEVT or BMM groups, including those who received rEVT after deterioration. The...
Purpose Hypoalbuminemia, which is indicative of protein-energy malnutrition, linked to increased morbidity and mortality in acute surgical patients due catabolism. This study evaluates the relationship between preoperative serum albumin levels postoperative who underwent open abdominal surgery. Methodology We used Operating Room Management Information System (ORMIS) coding retrospectively find a complete list surgeries from January 2021 June 2023 using term "laparotomy" "open surgery"....
To differentiate between pseudo occlusion (PO) and true (TO) of internal carotid artery (ICA) is important in thrombectomy treatment planning for patients with acute ischemic stroke. Although delayed contrast filling has been differentiated PO from TO, its application limited by the implementations multiphasic computed tomography angiography. In this study, we hypothesized that ring sign, which readily acquired single-phasic CTA, can sufficiently TO PO.
Background The influence of leukoaraiosis in patients with acute ischemic stroke (AIS) given intra-arterial treatment (IAT) or without preceding intravenous thrombolysis (IVT) remains unknown. Objective To assess the clinical and radiological outcomes IAT leukoaraiosis. Methods Patients direct mechanical thrombectomy trial (DIRECT-MT) whose grade could be assessed were included. DIRECT-MT was a randomized performed China to effect compared plus IAT. We employed Age-Related White Matter...
Nonalcoholic fatty liver disease (NAFLD) has become a common disorder caused by lipid accumulation and insulin resistance (IR). Acylcarnitines have new biomarker of IR. However, their roles in NAFLD are still poorly studied. Thus, we performed targeted metabolomic analysis to study the level plasma acylcarnitines patients with NAFLD.The levels 34 were measured approach (n = 50) healthy control subjects liquid chromatography-tandem mass spectrometry. Detailed demographic clinical...
To explore the clinical prognosis and factors after mechanical thrombectomy (MT) in patients with large cerebral infarction assessed by computed tomographic perfusion (CTP)and optimal threshold of blood flow (CBF) for estimating ischemic core.We analyzed data from anterior circulation database our hospital (August 2018-June 2021). Multivariate logistic regression analyses identified predictors outcomes baseline infarcts (>50 ml) MIStar software. The receiver operating characteristic (ROC)...
Background: Vessel perforation during stent mechanical thrombectomy (MT) is a rare and disastrous complication. A routine rescue strategy includes balloon occlusion for tamponade, procedure suspension, lowering or normalizing blood pressure. However, this complication still associated with poor outcome high mortality. Objective: We present our experience intra-arterial injection of thrombin in the treatment vessel secondary to microcatheter/microwire perforation, which prevents further...
JOURNAL/nrgr/04.03/01300535-202512000-00028/figure1/v/2025-01-31T122243Z/r/image-tiff Adipose-derived stem cell, one type of mesenchymal cells, is a promising approach in treating ischemia-reperfusion injury caused by occlusion the middle cerebral artery. However, its application has been limited complexities ischemic microenvironment. Hydrogel scaffolds, which are composed hyaluronic acid and chitosan, exhibit excellent biocompatibility biodegradability, making them candidates as cell...
As a classic immunoregulatory cytokine, interleukin-10 (IL-10) can provide in vivo and vitro neuroprotection respectively during cerebral ischemia after the oxygen-glucose deprivation (OGD)-induced injury. However, its role cortical neuronal survival at different post-ischemic phases remains unclear. The current study found that IL-10 had distinct effects on apoptosis OGD stages: an early stage OGD, promoted OGD-induced cultured primary neurons by activating p65 subunit, which up-regulated...
Osteosarcoma is a malignant bone tumor prevalent in adolescents with poor prognosis. Toona sinensis showed potent antiproliferation effect on lung, melatonin, ovary, colon, and liver cancers. However, the effects of species osteosarcoma cells are rarely investigated.In this study, we found fraction 1 leaf (TSL-1) resulted inhibition cell viability MG-63, Saos-2, U2OS lines, while it only caused moderate suppressive normal osteoblasts. In addition, TSL-1 significantly elevated lactate...