A5040617358- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Hepatitis C virus research
- Peripheral Artery Disease Management
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related cognitive impairment studies
- Vibrio bacteria research studies
- Healthcare Policy and Management
- Cardiac Imaging and Diagnostics
- Healthcare professionals’ stress and burnout
- Diverticular Disease and Complications
- Spondyloarthritis Studies and Treatments
- Flavonoids in Medical Research
- Dermatological and Skeletal Disorders
- Cancer Mechanisms and Therapy
- Bacillus and Francisella bacterial research
- Trauma Management and Diagnosis
- Education, Safety, and Science Studies
- Skin and Cellular Biology Research
- Drug-Induced Hepatotoxicity and Protection
- Work-Family Balance Challenges
- Glioma Diagnosis and Treatment
- Marine and Coastal Research
- Cardiac Structural Anomalies and Repair
Chiayi Chang Gung Memorial Hospital
2018-2024
Chang Gung University
2011-2024
National Taiwan University Hospital
2015-2024
National Taiwan University
2024
Soochow University
2024
National Health and Family Planning Commission
2022
Nanjing Medical University
2021-2022
Weatherford College
2021
Jiangsu Province Hospital
2021
First Affiliated Hospital of Zhengzhou University
2021
Background and Purpose: EVT is a standard treatment for LVO in patients with an NIHSS score ?6, but its role mild stroke (NIHSS <6) remains uncertain. This study aims to explore the association between clinical outcomes stroke. Methods: non-randomized cohort prospectively enrolled consecutive at 35 comprehensive centers across 15 Chinese provinces from January 2020 December 2023. Patients were categorized into pEVT or BMM groups, including those who received rEVT after deterioration. The...
Abstract There are currently limited therapeutic regimens available for effective treatment of hepatocellular carcinoma (HCC). Silymarin is a naturally derived polyphenolic antioxidant with hepatoprotective properties and very widely used in clinical application; however, effect silymarin on spontaneous HCC has not been studied. was evaluated its efficacy against carcinogenesis using the HBV X protein (HBx) transgenic model. p.o. given to HBx mice from 4 6 weeks age. Our data indicated that...
Background: Etanercept was highly recommended for patients with ankylosing spondylitis (AS), as its efficacy has been confirmed in AS, while genetic polymorphisms, by affecting drug metabolism or receptor, lead to interindividual variability disposition and efficacy. Therefore, this study aims investigate whether ABCB1 gene polymorphisms can predict therapeutic response etanercept AS. Methods: A total of 185 AS our hospital were recruited into from December 2012 May 2015. The frequency...
Abstract OBJECTIVE. This study investigated separate and concurrent performance on cognitive hand dexterity tasks the relationship to daily functioning in 16 people with schizophrenia healthy control participants. METHOD. Participants performed Purdue Pegboard Test Serial Seven Subtraction under single- dual-task conditions completed two evaluations. RESULTS. The of all participants declined condition, but discrepancy between single-task was greater group than (p &lt; .03, d &gt;...
Backgrounds . The objective of this study was to investigate the relationships among intention leave, emergency physician clinical activities, work-family conflicts, and gender differences in physicians (EPs). Methods survey instrument a self-administered questionnaire containing basic demographic information characteristics activities. conflicts were assessed by Chinese version conflict (WIF) scale. questionnaires mailed board-certified EPs between January 2014 August 2014. Student’s t...
Abstract Background Neuroblastoma (NB), a type of solid tumor in children, has poor prognosis. Few blood biomarkers can accurately predict the prognosis, including recurrence and survival, children with NB. In this study, we found that serum total cholesterol (Tchol) level was associated prognosis patients through retrospective study. Methods Multivariate Cox regression model used to identify independent risk factors Kaplan–Meier method analyze correlation between common biomarkers, Tchol...
Objectives . Frequent attendance for nonemergency problems to emergency departments (EDs) contributes ED overcrowding, resulting in medical care delays, increased errors, and social economic burdens. Most studies regarding frequent attenders of EDs examine general patients without classifying certain subgroups. This study aimed investigate with liver cirrhosis who present repeatedly the ED. Methods was a retrospective, observational cohort adult history presenting from January 2011 December...
Abstract Background Diabetes mellitus is a known risk factor for infection. Pay Performance (P4P) program designed to enhance the comprehensive patient care. The aim of this study evaluate effect P4P on infection incidence in type 2 diabetic patients. Methods This retrospective longitudinal cohort using data from National Health Insurance Research Database Taiwan. Diabetic patients between 1 January 2002 and 31 December 2013 were included. Primary outcomes analyzed emergency room (ER) events...
Background G. hollisae thermostable direct hemolysin (Gh-TDH) is produced by most strains of hollisae. This toxin has been reported to be absorbed in the intestines humans. Secondary liver injury might caused venous return through portal system. We aimed firstly analyze vitro and vivo hepatotoxicity Gh-TDH. Methods Liver cells (primary human non-cancer cell FL83B mouse cells) were treated mice (BALB/c) fed with this investigate its hepatotoxicity. Morphological examination cytotoxicity...
Vibrio hollisae, a halophilic species recently reclassified as Grimontia is causative agent of gastroenteritis and septicaemia. One important pathogenic factor, thermostable direct haemolysin (TDH), has been purified crystallized in two crystal forms using the vapour-diffusion method. The crystals belonged to an orthorhombic space group, with unit-cell parameters = 104.8, b 112.4, c 61.3 Å 122.9, 123.3, 89.8 Å. contained either four or eight molecules per asymmetric unit, predicted solvent...
Introduction To identify factors associated with ST-segment myocardial infarction (STEMI) patients who had no chest pain, and to improve recognition of STEMI without presentation pain in the emergency department (ED). Method Clinical characteristics presentations were recorded diagnosed ED a retrospective study treated from 2006 2009. Patients compared according clinical features. Results Among 260 patients, 12.7% ED. Syncope, epigastric dyspnea accounted for more than 60% symptoms pain....
Adjuvant chemotherapy for breast cancer might impact cognitive function and brain structure. In this study, we investigated the cerebral microstructural changes in survivors after adjuvant correlation with longitudinal study designs. The results showed volume reduction thefrontal temporal regions were also observed patients from baseline to postchemotherapy. An association between performance was found limbic system. According our findings, useful developing a prediction model as well guide...
Background: Adjuvant chemotherapy for breast cancer might impact cognitive function and brain structure. Methods: In this study, we investigated the cerebral microstructural changes in survivors after adjuvant correlation with both cross-sectional longitudinal study designs. All participants underwent structural MRI. total, recruited 67 prechemotherapy patients (BB), postchemotherapy (BA), 77 healthy controls (BH). For follow-up 28 BH BB groups returned imaging assessment (BHF, BBF)....
<title>Abstract</title> Background There is a growing incidences of hepatosteatosis and metabolic syndrome in young adults worldwide. This study aimed to address these gaps by systematically evaluating simple indices clinical practice strengthen the prediction prevention adults. Methods Of 4,067 (20–40 years old) who underwent community health check-up between March December 2022, 3,796 (93%) were eligible for analysis. The characteristics participants with without moderate-to-severe fatty...
Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant pharmacological activities but have limited vivo efficacy due to low water solubility poor bioavailability. Here, we generated luteolin monophosphate derivatives (LutPs ApnPs) individually via microbial biotransformation. We then characterized their physicochemical properties evaluated vitro pharmacokinetics Both LutPs ApnPs showed enhanced dissolution remained stable simulated...
A retrospective cohort study was conducted using claims data from Taiwan's National Health Insurance program to assess the effect of diabetic pay-for-performance (P4P) on major adverse limb events (MALE) and cardiovascular (MACE) in patients with type 2 diabetes mellitus (T2DM). This included T2DM who had completed or not a 1-year P4P 2002 2013. Propensity-score matching used balance baseline characteristics between groups. The Cox proportional-hazard model Fine Gray subdistribution hazard...
Background: Hepatitis C virus (HCV) infection is associated with a higher risk of chronic kidney disease (CKD). This study investigates the relationship among HCV, CKD, and understudied confounders, such as unhealthy behaviors metabolic disturbances. Methods: cross-sectional was conducted part community health promotion program in an HCV endemic area Taiwan from June to December 2019. Multivariable logistic regression analyses adjusted for demographic clinical characteristics were performed...
Abstract. Background: We previously found that dehydration is an independent predictor of early deterioration after acute ischemic stroke and rehydration helps to improve outcomes. There limited evidence how treat patients who are initially non-dehydrated. In this study, we tested the hypothesis therapy, based on daily urine specific gravity, will outcome Methods: conducted a single-arm prospective study with historical controls. For first 5 days group, gravity > 1.020 g/ml was taken as...
Abnormalities of the ERCC1 gene can affect DNA repair pathways, thereby having a vital effect on genomic stability. A growing amount case-control studies have focused making an investigation association between rs11615 polymorphism and cervical cancer susceptibility. However, controversial results raised concerns. To draw more accurate conclusion, six were elaborately selected from electronic databases for this meta-analysis, with 753 cases 851 healthy controls. We applied pooled ORs...