A5086565881- RNA Research and Splicing
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Lipid metabolism and biosynthesis
- HIV-related health complications and treatments
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Traditional Chinese Medicine Analysis
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Neurological Disease Mechanisms and Treatments
- Biochemical and Molecular Research
- Cytomegalovirus and herpesvirus research
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS Research and Interventions
- Dialysis and Renal Disease Management
- Ocular Diseases and Behçet’s Syndrome
- Head and Neck Cancer Studies
- Coronary Artery Anomalies
- Epigenetics and DNA Methylation
- Ginger and Zingiberaceae research
National Defense Medical Center
2000-2025
Taipei Medical University
2015-2025
Tri-Service General Hospital
2000-2025
Wan Fang Hospital
2020-2023
Midwestern University
2021
Taichung Veterans General Hospital
2019
Institute of Biomedical Sciences, Academia Sinica
2005-2012
Academia Sinica
2011
National Taiwan University
2005-2007
National Yang Ming Chiao Tung University
2002-2006
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that systemic inflammation increases the risk of Parkinson's (PD). This study examined effects IBD on development PD. In nationwide population-based cohort 23.22 million insured residents Taiwan aged ≥ 20 years, we compared people diagnosed with during 2000 to 2011 (n = 8373) IBD-free individuals. Patients PD were identified in National Health Insurance Research Database. Using univariable...
RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such as arsenite exposure induces phosphorylation RBM4 at serine 309 and also drives its cytoplasmic accumulation targeting to granule via the MKK(3/6)-p38 signaling pathway. Accordingly, suppresses cap-dependent translation cis-element-dependent manner. However, concomitantly activates internal ribosome entry site (IRES)-mediated likely by promoting association...
Imbalanced splicing of premessenger RNA is typical tumorous malignancies, and the regulatory mechanisms involved in several tumorigenesis-associated events are identified. Elevated expression serine-arginine protein kinase 1 (SRPK1) may participate pathway responsible for dysregulation malignant tumor cells. In this study, we observed a correlation between cytoplasmic accumulation RNA-binding motif 4 (RBM4) up-regulated SRPK1 breast cancer The production IR-B MCL-1 S transcripts was induced...
Alternative splicing contributes largely to cell differentiation and functional specification. We previously reported that the RNA-binding protein RBM4 antagonizes activity of factor PTB modulate muscle cell–specific exon selection α-tropomyosin. Here we show down-regulation its neuronal analogue nPTB during may involve alternative splicing-coupled nonsense-mediated mRNA decay. regulates PTB/nPTB expression by activating skipping their transcripts myogenesis. Moreover, target a common set...
RNA-binding motif protein 4 (RBM4) has been implicated in the regulation of precursor mRNA splicing. Using differential display analysis, we identified mRNAs that associate with RBM4-containing messenger RNPs vivo. Among these mRNAs, alpha-tropomyosin (alpha-TM) is known to exhibit a muscle cell type-specific splicing pattern. The level skeletal muscle-specific alpha-TM isoform partially correlated RBM4 human tissues examined and could be modulated by ectopic overexpression or suppression...
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by bile duct destruction, cholestasis, and inflammation, often leading to fibrosis cirrhosis. While ursodeoxycholic acid (UDCA) the standard treatment, some patients exhibit suboptimal responses, necessitating adjunctive therapies. Molecular hydrogen (H2), known for its antioxidant anti-inflammatory properties, has shown potential in mitigating oxidative stress immune dysregulation diseases. This case...
The RNA-binding motif protein 4 (RBM4) plays multiple roles in mRNA metabolism, including translation control. RBM4 suppresses cap-dependent but activates internal ribosome entry site-mediated translation. Because of its high expression level muscle and heart, we investigated the function myoblast cells. Here, demonstrate that is phosphorylated translocates to cytoplasm mouse C2C12 cells upon cell differentiation. Notably, transiently deposited into cytoplasmic granules containing...
The RNA-binding protein motif 4 (RBM4) modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation. To better understand the physiological function RBM4, we exploited a gene knockout strategy in present study. Mice with targeted disruption one two Rbm4 genes exhibited hyperglycemia coincident reduced levels serum insulin and size pancreatic islets. embryonic pancreases Rbm4-deficient mice showed expression or aberrant many transcripts encoding factors...
Abstract Kawasaki disease (KD) is an acute, inflammatory and self-limited vasculitis affecting infants young children. Coronary artery aneurysm (CAA) formation the major complication of KD leading cause acquired cardiovascular among To identify susceptible loci that might predispose patients with to CAA formation, a genome-wide association screen was performed in Taiwanese cohort. Patients both had longer fever duration delayed intravenous immunoglobulin treatment time. After adjusting for...
Abstract Human CMV (HCMV) is a widespread human pathogen that causes blindness by inducing retinitis in AIDS patients. Previously, we showed viral immediate early 2 (IE2) protein may allow HCMV to evade the immune control killing Fas receptor-positive T lymphocytes attracted infected retina with increased secretion of ligand (FasL). In this study, further demonstrate secreted FasL also kills uninfected Fas-rich bystander retinal cells and IE2 simultaneously protects from undergoing apoptotic...
A growing body of study have documented the association gut dysbiosis or fecal metabolites with chronic kidney disease (CKD). However, it is not clear whether phenomenon simply reflects microenvironment changes correlated CKD severity contributes to progression CKD. In this study, we identified microbiota and metabolite in feces samples using Nanopore long-read sequencing platform UPLC-coupled MS/MS approach. cross-sectional cohort was performed from 1 June 2020 31 December 2020. One hundred...
HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, population-based study investigate the cumulative effect of different types ART regimens on in Taiwanese HIV/ART cohort. A total 13,370 (2,674 10,696 non-hyperlipidemia patients) were recruited after matching age, gender, first diagnosis date HIV infection by using National Health Insurance Research Database Taiwan....
Myocyte enhancer factor 2c (MEF2C) is the MADS-box type transcription involved in differentiation of cardiac and skeletal muscle synaptic formation. Alternatively spliced transcripts MEF2C gene were proven to encode isoforms which exert distinct functions transcriptional regulation. During brown adipocytes, upregulated RBM4 enhanced skipping MEF2Cγ region as a repressor. The presence an overexpressed MEF2Cγ- isoform turn induced activity promoter, constituting positive feedback circuit...