A5103060237- Galaxies: Formation, Evolution, Phenomena
- Gamma-ray bursts and supernovae
- Astronomy and Astrophysical Research
- Astrophysical Phenomena and Observations
- Adipose Tissue and Metabolism
- Stellar, planetary, and galactic studies
- Metabolism, Diabetes, and Cancer
- Astrophysics and Cosmic Phenomena
- Pneumothorax, Barotrauma, Emphysema
- Stroke Rehabilitation and Recovery
- Electromagnetic Compatibility and Noise Suppression
- Trauma Management and Diagnosis
- Chronic Disease Management Strategies
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Microwave and Dielectric Measurement Techniques
- Pleural and Pulmonary Diseases
- Microwave Engineering and Waveguides
- Pulsars and Gravitational Waves Research
- Cardiac Valve Diseases and Treatments
- Acute Ischemic Stroke Management
- Radio Astronomy Observations and Technology
- Cosmology and Gravitation Theories
- Health Systems, Economic Evaluations, Quality of Life
- Pesticide and Herbicide Environmental Studies
National Taiwan University Hospital
2021-2025
Kaohsiung Veterans General Hospital
2019-2025
National Tsing Hua University
2014-2024
Chi Mei Medical Center
2024
Chung Yuan Christian University
2024
Urbana University
2024
National Yang Ming Chiao Tung University
2009-2024
University of Illinois Urbana-Champaign
2020-2023
National Health Research Institutes
2011-2023
National Cheng Kung University
2022-2023
Background It is of paramount importance to evaluate the impact participation in organized mammography service screening independently from changes breast cancer treatment. This can be done by measuring incidence fatal cancer, which based on date diagnosis and not death. Methods Among 549,091 women, covering approximately 30% Swedish screening‐eligible population, authors calculated rates 2473 cancers that were within 10 years after 9737 advanced cancers. Data regarding each cause death case...
Abstract Background Women and their health care providers need a reliable answer to this important question: If woman chooses participate in regular mammography screening, then how much will choice improve her chances of avoiding death from breast cancer compared with women who choose not participate? Methods To question, we used comprehensive registries for population, screening history, incidence, disease‐specific data defined population Dalarna County, Sweden. The annual incidence was...
Background Enterovirus 71 (EV71) infections manifest most commonly as a childhood exanthema known hand-foot-and-mouth disease (HFMD) and can cause neurological during acute infection. Principal Finding In this study, we describe the production, purification characterization of EV71 virus produced from Vero cells grown in five-liter serum-free bioreactor system containing 5 g/L Cytodex 1 microcarrier. The viral titer was >106 TCID50/mL by 6 days post infection when MOI 10−5 used at initial...
ABSTRACT Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by point mutation on the LMNA gene. We reported previously that accumulation of nuclear envelope protein SUN1 contributes to HGPS aberrancies. However, mechanism which interactions between mutant lamin A (also known as progerin or LAΔ50) and produce cellular phenotypes requires further elucidation. Using light electron microscopy, this study demonstrated progerin-elicited structural changes in...
K. pneumoniae is the predominant pathogen isolated from liver abscesses of diabetic patients in Asian countries. Although elevated blood glucose levels cause various immune problems, its effects on virulence are unknown. This study investigated regulation capsular polysaccharide (CPS) biosynthesis, a major determinant for virulence, response to exogenous glucose. We found that produce more CPS glucose-rich medium via reduction cyclic AMP (cAMP) levels. Individual deletion cyaA or crp, which...
Does transforming growth factor-β1 (TGF-β1) up-regulate connexin43 (Cx43) to promote cell–cell communication in human granulosa cells? TGF-β1 up-regulates Cx43 and increases gap junction intercellular activities (GJIC) cells, this effect occurs via the activin receptor-like kinase (ALK)5-mediated Sma- Mad-related protein (SMAD)2/3-SMAD4-dependent pathway. its receptors are expressed follicular fluid contains protein. In junctions play an important role development of follicles oocytes. This...
This study aimed to investigate the therapeutic efficacy of combined hyperbaric oxygen therapy (HBOT) and steroid in treating sudden sensorineural hearing loss (SSNHL). retrospective analysis included 505 patients diagnosed with SSNHL from August 2017 July 2022. The received either a systemic (SS) alone or SS HBOT. Hearing improvement was evaluated pure-tone audiometry (PTA). Among participants, 102 + HBOT, whereas 403 were treated alone. HBOT group demonstrated significantly better PTA...
In galaxy mergers, dual quasars - two actively accreting supermassive black holes (SMBHs) provide a unique opportunity to study the interplay between dynamics and quasar activity. However, very little is known about their molecular gas, which fuels star formation this study, we map kinematics of cold gas in J0749+2255, 3.8 kpc separation at z=2.17 using Atacama Large Millimeter Array (ALMA) Band 4. We detect CO(4-3)650um, shows remarkably complex morphological kinematic structures. While...
Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that responsible for inactivating intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP), which stimulates a decline in blood glucose levels. The aim of this study was to explore inhibition activity small molecule inhibitors DPP-4 following computational strategy based on docking studies molecular dynamics simulations. thorough protocol we applied allowed us derive good correlation parameters between...
Background: The impact of pay-for-performance (P4P) programs on long-term mortality for chronic illnesses, especially diabetes mellitus, has been rarely reported. Several studies described the favorable P4P mellitus medical utilizations or intermediate outcomes. Therefore, this study aimed to investigate a program in patients with type 2 diabetes. Methods: group population-based cohort was 2090 individuals primary diagnosis who had newly enrolled Taiwan between January 1, 2004 and December...
We hypothesized that sorafenib plus transarterial chemoembolization (TACE) would confer survival benefits over alone for advanced hepatocellular carcinoma (aHCC). investigated this while using the population-based All-Cancer Dataset to assemble a cohort (n = 3674; median age, 60; 83% men) of patients receiving aHCC (Child-Pugh A) with macro-vascular invasion or nodal/distant metastases. The were classified into sorafenib-TACE group 426) propensity score-matched sorafenib-alone 1686). All...
The statistics of galactic-scale quasar pairs can elucidate our understanding the dynamical evolution supermassive black hole (SMBH) pairs, duty cycles activity in mergers, or even nature dark matter, but have been challenging to measure at cosmic noon, prime epoch massive galaxy and SMBH formation. Here we a double fraction $\sim 6.2\pm0.5\times 10^{-4}$ integrated over 0.3-3$ arcsec separations (projected physical 3-30\,{\rm kpc}$ $z\sim 2$) luminous ($L_{\rm bol}>10^{45.8}\,{\rm...
Few studies compared the diagnostic value of procalcitonin with a combination other tests including lactate and high-sensitivity C-reactive protein in prediction pathogenic bacteremia emergency department adult patients.We performed retrospective study assessing differences performances at cutoff 0.5 ng/mL, 19.8 mg/dL, 0.8 mg/dL their combinations for predicting patients. Sensitivity, specificity, overall accuracy, positive-test negative-test likelihood, odds ratio 95% confidence interval...
Using a non-invasive method to select the most competent embryo is essential in vitro fertilization (IVF). Since beginning of clinical application time-lapse technology, several studies have proposed models using imaging system for predicting IVF outcome. This study used both morphokinetic and morphological dynamic parameters embryos with highest developmental potential. A total 23 intracytoplasmic sperm injection treatment cycles 138 fertilized oocytes were included this study. All cultured...
Stress concentration at the TiO 2 -layered silicate magadiite (LSM) interface enhances NRR performance of @LSM via piezo-photocatalysis, providing a low-emission alternative to conventional ammonia production methods.
Chen, Yu-Ching, Shin-Da Lee, Low-Tone Ho, and Cha-Hua Kuo. The effects of altitude training on the AMPK-related glucose transport pathway in red skeletal muscle both lean obese Zucker rats. High Alt. Med. Biol. 12:371–378.—Introduction: AMP-activated protein kinase (AMPK) is involved homeostasis. Aim: In this study, we examined whether rats had abnormal expression proteins LKB1-AMPK-AS160-GLUT4 gastrocnemius compared to that We also chronic hypoxia-exercise Methods: At sea level, were...
Accumulating evidence suggests that metformin reduces incident cancer development. Few cohort studies have evaluated the risk of subsequent development in diabetic cohorts receiving antidiabetic monotherapy. We conducted a population-based study patients with new-onset type 2 diabetes treated monotherapy.We identified diabetics aged ≥30 years hypoglycemic monotherapy (n=7,325) from 1998-2007 Longitudinal Health Insurance Dataset. Patients were grouped according to therapy they received into...
IscR, an Fe–S cluster-containing transcriptional factor, regulates genes involved in various cellular processes. In response to environmental stimuli such as oxidative stress and iron levels, IscR switches between its holo apo forms regulate targets. binding sequences are classified into two types: the type 1 box that is specific for holo-IscR binding, 2 binds holo- apo-IscR. Studying Klebsiella pneumoniae CG43S3, we have previously shown availability capsular polysaccharide (CPS)...