A5076062595- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- High Altitude and Hypoxia
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Peripheral Artery Disease Management
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- ATP Synthase and ATPases Research
- Thermoregulation and physiological responses
- RNA and protein synthesis mechanisms
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Health disparities and outcomes
- Impact of Technology on Adolescents
Shandong University
2024-2025
Shanghai University of Sport
2017-2022
East China Normal University
2016-2022
Bridge University
2021
High-intensity interval training (HIIT) is reported to be beneficial brain-derived neurotrophic factor (BDNF) biosynthesis. A key element in this may the existence of lactate, most obvious metabolic product exercise. In vivo , study investigated effects a 6-week HIIT on peripheral and central lactate changes, mitochondrial quality control system, function BDNF expression mouse hippocampus. vitro primary cultured mice hippocampal cells were used investigate role underlying mechanisms...
This study aims to investigate the associations of objectively measured daily steps and step intensity with peripheral arterial disease (PAD) in Chinese community-dwelling older women. Cross-sectional data were derived from baseline survey Physical Activity Health Older Women Study. Peripheral was evaluated through ankle-brachial index (ABI), ABI ≤ 0.9 defined as cut-off point. Daily via tri-axial accelerometers. Multivariate logistic regression used variable PAD. Receiver operating...
To investigate the association among multidimensional (Digital engagement, DE; Digital devices, DD; and purpose, DP) digital technology use depression in older Chinese, considering social participation as a mediator physical activity level (PAL) moderator. Data on 5,744 participants (aged≥60) were extracted from China Health Retirement Longitudinal Study 2020 dataset. Depression was assessed using 10-item Center for Epidemiologic Studies Scale. Logistic regression examined between...
Viperin is an interferon-inducible antiviral protein, responsible for response to a variety of viral infections. Here, we show that silencing viperin by antisense oligonucleotides (ASO) protects against diet-induced glucose intolerance, and yet exacerbates adipose tissue inflammation. In high-fat diet-fed mice, ASO improves homeostasis, reduces plasma triglyceride concentrations ameliorates hepatic steatosis. Peripheral delivery adeno-associated virus elevates fasting insulin...
Lipotoxicity of palmitic acid (PA) or high-fat diets has been reported to increase endoplasmic reticulum (ER) stress and autophagy in peripheral tissue as well apoptotic cell death. It also can lead an AD-like pathological pattern. However, it unknown that PA-induced ER are involved the regulation neuroplastic abnormalities. Here, we investigated roles apoptosis neuroplasticity-related protein expression PA-treated prefrontal cells. Prefrontal cells dissected from newborn Sprague-Dawley rats...
The neurotrophic hypothesis of depression posits that stress and decrease factor expression in brain, whereas antidepressants exercise can contribute to the blockade effects produce antidepressant effects. Fibroblast growth 9 (FGF9), a member fibroblast (FGF) family, has been reported be dysregulated depression. present study aimed determine whether how Fgf9 mediates fluoxetine chronic unpredictable mild (CUMS) mice.Male C57BL/6 mice were exposed CUMS for 7 weeks. From fourth week,...
Objective: To investigate the changes of pyroptosis-related proteins in hippocampus insulin-resistant mice and regulation resistance training on proteins. Methods: Six-week-old male C57BL/6J were randomly divided into control group (C, n=12) high-fat diet (HFD, n=26) for normal or 12 weeks. Subsequently, according to results glucose tolerance test (GTT) insulin (ITT), rats fed with (IR, n=10) exercise (RT, as well maintain diet. At same time, RT subjected training. After weeks, all...
Objective: This study aims to explore the independent and combined associations of physical activity (PA) in different domains inflammatory diet with type 2 diabetes mellitus (T2DM). Methods: Data from 8736 American adults NHANES 2007–2016 were used. PA was assessed using self-reported Global Physical Activity Questionnaire, dietary index estimated based on 24 h recalls. T2DM diagnosis determined by a combination self-report laboratory data. A multivariate modified Poisson regression model...
Abstract Inhibiting glycemic response to HPA axis contributes control for diabetic patients. Here, mice were subjected high-fat diet and intermittent chronic stress, glucose homeostasis lipolysis determined during the intervention. Firstly, we found that intolerance appears at earliest, followed by reduced insulin sensitivity increased epinephrine (EPI) in early stage of diet-induced obesity. Next investigated whether stress impairs which mediates its effects. Short-term training raises...
Objective Recent studies suggest that chronic stress exposure can ameliorate the progression of diet-induced prediabetic disease, by inhibiting an increase in weight gain, caloric intake and efficiency insulin resistance. To determine underlying mechanism which improves type 2 diabetes, we developed a model mild high-fat diet(HFD)-fed mice are resistant to obesity exhibit healthy-like metabolic phenotype.
 Methods High-fat diet (HFD): 45% kcal derived from fat (Research Diets,...
Abstract FAM132b, also known as myonectin, has been identified a myokine produced by exercise. It is secreted protein precursor that belongs to the adipolin/erythroferrone family, and hormone activity in circulation regulate cellular iron homeostasis lipid metabolism via unknown receptors. Here, adeno-associated viral vectors (AAV9) were engineered induce overexpression of FAM132b with 2 codon mutations (A136T P159A). Treatment mice under high-fat diet feeding gene transfer resulted marked...