A5101868789- Urinary Bladder and Prostate Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Healthcare and Venom Research
- Renal and related cancers
- Adrenal and Paraganglionic Tumors
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Medicinal Plant Pharmacodynamics Research
- Cardiac Ischemia and Reperfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunotherapy and Immune Responses
- Vascular Malformations and Hemangiomas
- Tendon Structure and Treatment
- Sexuality, Behavior, and Technology
- Multiple and Secondary Primary Cancers
- Sexual function and dysfunction studies
First Affiliated Hospital of Nanchang University
2014-2025
Nanchang University
2014-2025
ZheJiang Institute For Food and Drug Control
2024-2025
Southwest University
2025
Kunming Medical University
2024-2025
First Affiliated Hospital of Jiangxi Medical College
2024
China Pharmaceutical University
2008
The incidence of bladder cancer (BCa) is increasing worldwide and the development drug targets for BCa necessary. We conducted a proteome-wide association study (PWAS) mainly using mendelian randomization (MR) to explore causal proteins associated with BCa. Protein quantitative trait locis (pQTLs) were derived from two large proteome genome-wide studies. After validation by multiple sensitivity analysis replication analyses, we identified five plasma showed significant associations Our...
To investigate the influence of preoperative noninvasive indexes on surgical outcomes benign prostatic hyperplasia (BPH) patients and to establish a clinical prediction model. A total 250 BPH treated with transurethral resection prostate (TURP) in our center from December 2020 June 2023 were included. The evaluation was completed by detailed history questionnaire, an international symptom score (IPSS) assessment, urological ultrasonography. Among included patients, 185 had effective...
This study successfully established and validated an efficient, reliable, user-friendly method for determining the anti-Xa factor potency of enoxaparin sodium. Comprehensive validation experiments demonstrated method’s excellent performance in terms specificity, linearity, precision, accuracy, robustness. The exhibited a linear detection range 0.054–0.192 IU/mL with strong correlation coefficient, its robustness, consistency European Pharmacopoeia were all within 2.0% relative standard...
Abstract Background To evaluate the feasibility and safety of robot-assisted retroperitoneal laparoscopic adrenalectomy (RARLA) for large pheochromocytomas (PHEOs; size≥6 cm) compared with (RLA). Methods Fifty-one patients who underwent PHEOs between March 2016 January 2019 were enrolled divided into two groups, including 32 RLA cases 19 RARLA cases. We perioperative efficacy long-term follow-up results groups. Results Preoperative data, demographics, comorbidities tumour characteristics,...
Long noncoding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Gastric adenocarcinoma-associated, positive CD44 regulator, long intergenic RNA (GAPLINC) is a recently identified lncRNA that can actively participate in tumorigenesis various cancers. Here, we investigated functional roles mechanism GAPLINC renal cell carcinoma (RCC) development.Differentially expressed lncRNAs between RCC tissues normal kidney were detected by using microarray technique....
Enoxaparin sodium is a low molecular mass heparin essential for effective anticoagulation therapy. However, significant variations in testing methods across different manufacturers have led to poor reproducibility of results, increasing the risks associated with drug quality evaluation by and regulatory oversight. This study integrates strengths various establish reproducible assay that has been thoroughly validated. The validation results demonstrate method exhibits excellent specificity,...
We investigated neovasculization effects of emboluscarried human vascular endothelial cell growth factor 165 (VEGF )encoded adenovirus (Ad) vector in the hindlimbs rats with thromboangiitis obliterans (TAO).Rats were equally divided into blank control (I), TAO model (II), embolus (III), Ad-VEGF intravascular treatment (IV), intramuscular (V), and (VI) groups.After interventional treatment, effect test gene was observed using immunohistochemistry.At 1 week after administration, compared group...
Objectives To analyze our experience in retroperitoneal laparoscopic adrenalectomy (RLA) with transient renal artery occlusion for large adrenal tumors (≥8 cm) and to explore the safety feasibility of this surgical procedure. Methods A retrospective cohort study was conducted a data review 18 patients who underwent RLA hospital. Results Eighteen were treated by artery, none converted open adrenalectomy. The time, operative estimated blood loss, perirenal drainage postoperative hospital stay,...
Long non‑coding RNAs (lncRNAs) have been demonstrated to serve vital roles in renal cell carcinoma (RCC) development. Gastric high expressed transcript 1 (GHET1) regulates numerous biological processes cancer cells. However, the role of GHET1 RCC has not yet identified. This study aimed investigate RCC. In present study, expression tissues and 786‑O, A498 293 lines was assessed by reverse transcription‑quantitative polymerase chain reaction. Cell Counting Kit‑8, colony formation scratch...
RNA binding proteins (RBPs) play significant roles in the development of tumors. However, a comprehensive analysis biological functions RBPs clear cell renal carcinoma (ccRCC) has not been performed. Our study aimed to construct an RBP-related risk model for prognosis prediction ccRCC patients. First, sequencing data were downloaded from The Cancer Genome Atlas (TCGA) database. Three RBP genes (EIF4A1, CARS, and RPL22L1) validated as prognosis-related hub by univariate multivariate Cox...
SNHG10 is a long non-coding RNA (lncRNA) found to be overexpressed in multiple human cancers including prostate cancer (PC). However, the underlying mechanisms of driving progression PC remains unclear. In this study, we investigated role and that expression was significantly increased datasets extracted from The Cancer Genome Atlas. Increased related advanced clinical parameters. Receiver operating curve analysis revealed significant diagnostic ability (AUC = 0.805). addition, immune...
A growing body of evidence has shown that activating spinal cord glial cells (typically astrocytes and microglial cells) is closely related to hyperpathia persistent pain.
<title>Abstract</title> Background To investigate the influence of preoperative noninvasive indexes on surgical outcomes benign prostatic hyperplasia (BPH) patients and to establish a clinical prediction model. Methods A total 250 cases BPH treated with transurethral resection prostate (TURP) in our center from December 2020 June 2023 were included. The evaluation was completed by detailed history questionnaire, an international symptom score (IPSS) assessment, urological ultrasonography....
In this study, the histological changes in sciatic nerves of rats after exposure to different doses focused ultrasound (FU) were investigated order provide an experimental basis for application FU peripheral nerve disorders. Forty-eight healthy male SD randomly divided into six groups. Each group was subjected times, including 10 s, 30 1 min, 2 3 min and 4 exposure. The irradiated target area centered 0.5 cm behind greater trochanter left femur with a 1-cm radius. A 1-cm-long segment within...
BACKGROUND The study aimed to investigate the expression of brain natriuretic peptide (BNP) and receptor A (NPR-A) in L6-S1 dorsal root ganglia (DRG) a rat model chronic nonbacterial prostatitis (CNP). MATERIAL AND METHODS One hundred specific pathogen-free (SPF) male Sprague-Dawley rats were randomly divided into control group (N=50) (N=50). underwent prostatic injection 0.1 ml normal saline on days 3, 7, 10, 14, 28. group, or CNP, complete Freund's adjuvant At end study, euthanized,...