H. William Higgins

ORCID: 0000-0003-0893-3334
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About
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Research Areas
  • Nonmelanoma Skin Cancer Studies
  • Cutaneous Melanoma Detection and Management
  • Cancer and Skin Lesions
  • Polyomavirus and related diseases
  • Cutaneous lymphoproliferative disorders research
  • Nail Diseases and Treatments
  • Reconstructive Facial Surgery Techniques
  • Infectious Diseases and Mycology
  • Full-Duplex Wireless Communications
  • Reconstructive Surgery and Microvascular Techniques
  • Skin Protection and Aging
  • Dermatologic Treatments and Research
  • Central Venous Catheters and Hemodialysis
  • Opioid Use Disorder Treatment
  • Antenna Design and Analysis
  • Vascular Procedures and Complications
  • Tumors and Oncological Cases
  • Nasal Surgery and Airway Studies
  • Dental Anxiety and Anesthesia Techniques
  • Pain Management and Opioid Use
  • CAR-T cell therapy research
  • Melanoma and MAPK Pathways
  • Genital Health and Disease
  • Vascular Malformations Diagnosis and Treatment
  • Vascular anomalies and interventions

Hospital of the University of Pennsylvania
2019-2025

National Institute of Diabetes and Digestive and Kidney Diseases
2025

University of Pennsylvania
2019-2024

Eastern Virginia Medical School
2024

Philadelphia University
2023

University of Pennsylvania Health System
2020-2021

Brown University
2012-2020

University of Leeds
2016

Boston University
2016

Providence College
2016

ObjectiveEarly thrombosis (ET) contributes to autogenous arteriovenous fistula (AVF) failure. We studied patients undergoing AVF placement in the Hemodialysis Fistula Maturation Study, a prospective, observational cohort study, using nested case-control analysis identify preoperative and intraoperative predictors of ET.MethodsET cases were compared with controls, who matched for gender, age, diabetes, dialysis status, surgeon volume. ET was defined as diagnosed by physical examination or...

10.1016/j.jvs.2015.07.086 article EN publisher-specific-oa Journal of Vascular Surgery 2015-12-21

<h3>Importance</h3> Defining which populations are affected by basal cell carcinoma (BCC) vs cutaneous squamous (cSCC) may inform targeted public health strategies. Incidence of BCC and cSCC is not reported to national cancer registries, but claims data for the treatment provide insights into epidemiology keratinocyte carcinoma. <h3>Objective</h3> To define differences in ratio adults (age, ≥18 years) a large database patients with commercial insurance Medicare Advantage coverage....

10.1001/jamadermatol.2020.2571 article EN JAMA Dermatology 2020-08-26

Abstract The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations wall shear stress (WSS) with subsequent AVF remodeling and clinical using regression models in this prospective cohort study. Participants underwent duplex ultrasound at postoperative Day 1, Week 2, 6 to measure blood flow rate diameter draining vein proximal artery. median WSS 602 participants decreased from 1 (from 33.4 21.6 dyne/cm 2 ) but did not change noticeably for...

10.1038/s41598-025-89896-z article EN cc-by Scientific Reports 2025-02-19

10.1177/0363546505275349 article EN The American Journal of Sports Medicine 2005-07-08

Reported physiologic nipple changes in pregnancy do not include hyperkeratosis and are expected to resolve or improve post partum. Hyperkeratosis of the and/or areola can develop context inflammatory diseases (such as atopic dermatitis), acanthosis nigricans, an extension epidermal nevus, after estrogen treatment, nevoid areola. We performed a clinicopathologic analysis cases pregnancy-associated hyperkeratosis.Twenty-five identified during 5-year period (January 1, 2007, through December...

10.1001/jamadermatol.2013.128 article EN JAMA Dermatology 2013-06-01

Mohs micrographic surgery (MMS) has increasingly become an accepted therapy for melanoma in situ on chronically sun damaged skin (CSDS). However, melanocytes are difficult to locate frozen material hematoxylin and eosin. In addition, determining the cut-off between "atypical melanocytic hyperplasia" CSDS can be challenging or formalin-fixed paraffin-embedded sections, with without immunohistochemistry (IHC). this article, we report use of a rapid, 35-minute protocol using...

10.1097/dad.0b013e3181bcd94f article EN American Journal of Dermatopathology 2010-03-23

Nonmelanoma skin cancer is the most common in United States, and when indicated, Mohs micrographic surgery (MMS) an effective method for tumor removal. Few studies have focused on gender-specific characteristics among those undergoing MMS. To elucidate patient- tumor-specific female MMS patients. We performed a retrospective chart review of 12,344 consecutive patients from 2005 to 2012. There was 1.5:1 male predominance presentation basal cell carcinoma (BCC) However, BCC comprised 72%...

10.1111/dsu.0000000000000020 article EN PubMed 2014-06-01

BACKGROUND Antibiotic prescriptions associated with dermatologic surgical visits are increasing and prescribing practices vary among surgeons. OBJECTIVE To describe surgeons' attitudes regarding prophylactic antibiotic use for site infection (SSI), to compare current those of a 2012 survey, determine interest in clinical trial data on the utility antibiotics. MATERIALS AND METHODS This was cross-sectional online survey American College Mohs Surgery (ACMS) members. Survey items were adapted...

10.1097/dss.0000000000002676 article EN Dermatologic Surgery 2020-09-02

Sentinel lymph node biopsy (SLNB) has not been studied for invasive melanomas treated with Mohs micrographic surgery using frozen-section MART-1 immunohistochemical stains (MMS-IHC). The primary objective of this study was to assess the accuracy and compliance National Comprehensive Cancer Network (NCCN) guidelines SLNB in a cohort patients who had melanoma MMS-IHC.This retrospective included all primary, invasive, cutaneous MMS-IHC at single academic center between March 2006 April 2018....

10.1002/cncr.33651 article EN Cancer 2021-07-22

Ornamental tattooing involves the administration of exogenous pigments into skin to create a permanent design. Our case focuses on 62-year-old woman who presented with an inflamed enlarging nodule her right proximal calf, which arose within red pigment ornamental tattoo. The was diagnosed as squamous cell carcinoma (SCC) and subsequently excised. Over course following year, patient total five additional SCCs that also increased popularity lack industry safety standards for tattoo ink...

10.1016/j.ijwd.2017.07.006 article EN cc-by-nc-nd International Journal of Women’s Dermatology 2017-08-25

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10.1001/jamadermatol.2019.2589 article EN JAMA Dermatology 2019-08-28

Background End‐stage renal disease is accompanied by functional and structural vascular abnormalities. The objective of this study was to characterize function in a large cohort patients with end‐stage disease, using noninvasive physiological measurements, correlate demographic clinical factors. Methods Results We analyzed cross‐sectional baseline data from the Hemodialysis Fistula Maturation Study, multicenter prospective observational 602 7 centers. Brachial artery flow‐...

10.1161/jaha.116.003227 article EN cc-by-nc-nd Journal of the American Heart Association 2016-07-06
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