A5028880855- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Long-Term Effects of COVID-19
- Pleural and Pulmonary Diseases
- Infectious Diseases and Mycology
- Otolaryngology and Infectious Diseases
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- Streptococcal Infections and Treatments
- Respiratory Support and Mechanisms
- Renin-Angiotensin System Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- vaccines and immunoinformatics approaches
- Infection Control and Ventilation
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Quinazolinone synthesis and applications
- Legionella and Acanthamoeba research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inhalation and Respiratory Drug Delivery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Aarhus University Hospital
2015-2025
Aarhus University
2014-2024
Latent infection with Mycobacterium tuberculosis is defined by a positive IFN-γ release assay (IGRA) result in the absence of active tuberculosis. Only few, mostly monocentric studies have evaluated role IGRAs to predict development recent contacts low-incidence countries tuberculosis.To analyze IGRA results and effect preventive chemotherapy on progression rates among contacts.Results from contact investigations at 26 centers 10 European including testing for latent M. QuantiFERON-TB Gold...
The epidemiology of nontuberculous mycobacteria (NTM) infections is not well described. In this study, we sought to determine the incidence and prevalence NTM focus on social risk factors. addition, describe people with pulmonary extrapulmonary NTM.
To describe neurophysiological abnormalities in Long COVID and correlate quantitative electromyography (qEMG) single fiber EMG (sfEMG) results to clinical scores histopathology. 84 patients with non-improving musculoskeletal symptoms were examined qEMG sfEMG. Muscle biopsies taken a subgroup. Mean motor unit potential (MUP) duration was decreased ≥ 1 muscles 52 % of the patients. jitter increased 17 tibialis anterior 25 extensor digitorum communis. Increased seen or without myopathic qEMG....
Lung abscess is a severe and complex respiratory infection. The purpose of this review to discuss recent publications on lung abscess, covering topics such as epidemiology, clinical presentation, diagnosis, treatment prevention.
<sec><title>BACKGROUND</title>Mortality and causes of death in non-tuberculous mycobacterial pulmonary disease (NTM-PD) are not well-described over long follow-up periods, particularly Europe. We investigated whether NTM-PD is associated with higher mortality rates different than matched controls.</sec><sec><title>METHODS</title>Danish national registers were used to identify patients from 2000–2017 match them 1:4 controls based on age, sex,...
Clinical characteristics of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) in Denmark are undescribed. This study investigated clinical and diagnostic practices NTM isolates. Patients Central Region from 2016 to 2021 were identified using nationwide mycobacteria data, hospital records reviewed for demographics, comorbidities, risk factors, details. Diagnostic guideline criteria NTM-PD assessed, compared between those who met the did not. Among 193 patients, M. avium...
Persistent symptoms after hospitalization with COVID-19 are common, but the frequency and severity of these insufficiently understood. We aimed to describe pulmonary function COVID-19. Patients hospitalized in Central Denmark Region were invited for follow-up 3 months discharge. Clinical characteristics, patient reported outcomes (Fatigue Assessment Scale (FAS), anxiety depression (HADS)), symptoms, test 6-min walk collected. included 218 patients (mean age 59.9 (95% CI: 58.2, 61.7), 59%...
Nontuberculous mycobacteria (NTM) are emerging as human pathogens at increasing rates. In Denmark, few studies of NTM exist, but these have not been able to confirm an trend. Existing utilised clinical data or investigated geographical variations.A retrospective cohort study patients with ICD-10 diagnostic code infection in a Danish region, Central Denmark Region, between 2011 and 2021. Incidence rates per 100,000 citizens were calculated using from Statistics Denmark. A Spearman's rank...
Objective To evaluate the impact of comorbidities, age and clinical presentation TB on mortality among Danish patients with TB. Methods an ICD-10 (International Statistical Classification Diseases Related Health Problems 10th Revision) diagnosis in 1998–2010 were identified National Patient Registry matched controls (1:4) age, gender, civil status geography. Comorbid diagnoses up to 3 years before after or enrolment as control well survival data obtained from national databases Results We...
This review focuses on the treatment of nontuberculous pulmonary disease caused by Mycobacterium avium complex and M. abscessus. It covers indications, antibiotic choice, resistance side effects. Treatment is complex, lengthy, fraught with Increased attention this needed in order to alleviate severe consequences growing disease. Cooperation between pulmonologists infectious specialists ensure uniform treatment, account for heterogeneity seen patients mycobacteria alike.
Over the past decades, prevalence and incidence of non-tuberculous mycobacteria pulmonary disease (NTM-PD) have increased worldwide, with Mycobacterium avium complex being most common causative agents [1–5]. The 2020 ATS/ERS/ESCMID/IDSA guidelines recommended a treatment regimen at least three drugs, including macrolide, in patients nodular-bronchiectatic, macrolide-susceptible (MAC-PD) [6]. For cavitary or advanced/severe bronchiectatic disease, suggest addition parenteral amikacin into...
ObjectiveTo evaluate the economic burden of tuberculosis (TB) in Denmark,Methods8,433 Danish TB-patients (1998-2010) were matched with 33,707 controls by age, gender, civil status and geography. Health-related costs (health system contacts –procedures, medications) socio-economic parameters (foregone earnings social transfer expenses) calculated on data from national databases. The same information was obtained for 3,485 spouses TB-patients, 17,403 controls.ResultsHealth-related higher cases...
Lung abscess (LA) is a serious respiratory infection often followed by several weeks of antibiotic treatment. This study described the clinical presentation LA, treatment duration and mortality in contemporary Danish population.In retrospective multicenter cohort at four hospitals, patients diagnosed with LA were identified using International Classification Diseases Related Health Problems 10th revision (ICD-10) between 2016 2021. A predefined data collection tool was used to extract on...
ABSTRACT Background and objective Co‐morbidities are frequent among patients with interstitial lung diseases (ILD). The of this study was to investigate their impact on mortality. Methods We used the Danish National Patient Registry (DNPR) identify all a first‐time diagnosis ILD between 1998 2010. Patients were matched 1:4 controls from background population. burden co‐morbidity assessed using Deyo–Charlson score (DCcs). Mortality risks Kaplan–Meier survival curves, hazard rate ratios (HRR)...
Extra-fine particle inhaled corticosteroids (ICS) improve peripheral airway distribution, but their effect on risk of exacerbations and all-cause mortality in patients with chronic obstructive pulmonary disease (COPD) is unclear.
Persistent symptoms on short-term follow-up after infection with COVID-19 are common, but long-term consequences have been insufficiently studied. The aim of this study was to characterize pulmonary function and ongoing 12 months hospitalization COVID-19.This prospective multicenter included 222 patients hospitalized PCR-confirmed in the Central Denmark Region. Disease severity stratified using WHO Clinical Progression Scale. characteristics, test (PFT), 6-minute walk (6MWT),...
Background: The serum-angiotensin I converting enzyme (s-ACE) activity is influenced by a genetic insertion/deletion (I/D) polymorphism in the ACE gene, and resulting large interindividual variation s-ACE limits use of normal reference intervals evaluation sarcoidosis. In this study, we developed new method for genotyping I/D established genotype-specific order to improve diagnostic accuracy value treatment Methods: assay based on high-resolution melting (HRM) using LCGreen + was used...
Background: Although chronic obstructive pulmonary disease (COPD) is one of the leading causes morbidity and mortality globally, several studies have shown little awareness COPD in general population. The Scandinavian countries is, however, sparsely investigated. Objective: aim this study was to explore Danish population smoking-related health risks symptoms related attitudinal factors concerning smoking. Design: Adults aged 18 years or older were randomly selected reflect background An...
Background. Isolation of patients suspected for pulmonary tuberculosis is guided by serial sputum smears. This can result in isolation days with noncontagious tuberculosis. To determine whether a single sample negative Mycobacterium complex at polymerase chain reaction (PCR) guide isolation. Methods. We retrospectively evaluated samples analyzed M. the International Reference Laboratory Mycobacteriology, Copenhagen, Denmark 2002–2011. selected culture-confirmed cases ≥3 within 14 before or...