A5051012077- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Inflammatory Myopathies and Dermatomyositis
- Rheumatoid Arthritis Research and Therapies
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- Eosinophilic Disorders and Syndromes
- Pneumonia and Respiratory Infections
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Treatments and Mutations
- Occupational exposure and asthma
- Delphi Technique in Research
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- Spondyloarthritis Studies and Treatments
- Medical Imaging Techniques and Applications
- Drug-Induced Adverse Reactions
Regionshospitalet Silkeborg
2015-2025
Aarhus University
2018-2024
Copenhagen University Hospital
2024
Regional Hospital Central Jutland
2021-2023
Aarhus University Hospital
2012-2019
To compare mortality risks in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and RA without ILD.Matched cohort study.The study was conducted Denmark, using nationwide, prospectively collected data.Among diagnosed between 2004 2016, 679 RA-ILD were matched for birth year, gender age at diagnosis 11 722 but ILD.Mortality assessed Kaplan-Meier curves, hazard rate ratios (HRRs) death estimated Cox proportional hazards regression models.The number of prevalent...
ABSTRACT Background and objective Unclassifiable disease in chronic interstitial lung ( ILD ) is a common challenging problem but has been insufficiently studied. The 2013 update of the international multidisciplinary classification idiopathic pneumonias presented based on observed behaviour with purpose providing guidance to clinicians management these patients. aim this study was apply new DBC previously validated ‐gender age physiology GAP score cohort unclassifiable patients assess...
Interstitial lung disease (ILD) is a serious extraarticular manifestation of rheumatoid arthritis (RA), but no evidence-based therapy exists. Ongoing studies investigate the role antifibrotic therapies for progressive fibrosing ILD (PF-ILD), including RA-ILD. The aim present study was to frequency PF-ILD and clinical characteristics RA-ILD in well-characterised, population-based cohort.We identified patients with diagnosed followed at referral centre Aarhus, Denmark, from 2004 2016. Adjusted...
To evaluate the Medical Research Council (MRC) dyspnoea scale and serum Microfibrillar-associated protein 4 (MFAP4) levels for detection of respiratory impairment in newly diagnosed rheumatoid arthritis (RA). Patients underwent blood tests, pulmonary function tests (PFT) assessment using MRC scale. Respiratory was defined as a diffusion capacity lungs carbon monoxide (DLCO) <80% predicted or FEV1/FVC <70%. The primary outcomes were MFAP4's sensitivity, specificity, diagnostic odds ratio...
Interstitial lung disease (ILD) is associated with impaired survival among patients connective tissue diseases (CTDs), but population-based data on the frequency of ILD and pulmonary hypertension (PH) in different CTD subtypes impact are sparse.We included a first-time ICD-10 diagnosis systemic sclerosis (SSc), mixed (MCTD), myositis, lupus erythematosus (SLE), or Sjögren's registered Danish National Patient Registry between 2000 2015. Among these, we identified PH. Using Kaplan-Meier...
Persistent symptoms after hospitalization with COVID-19 are common, but the frequency and severity of these insufficiently understood. We aimed to describe pulmonary function COVID-19. Patients hospitalized in Central Denmark Region were invited for follow-up 3 months discharge. Clinical characteristics, patient reported outcomes (Fatigue Assessment Scale (FAS), anxiety depression (HADS)), symptoms, test 6-min walk collected. included 218 patients (mean age 59.9 (95% CI: 58.2, 61.7), 59%...
Introduction Acute exacerbations of chronic obstructive pulmonary disease are associated with high morbidity and mortality. Telemonitoring may reduce the frequency hospitalization. The aim this study was to investigate effect telemonitoring on hospitalization rates for acute disease. Methods Patients were recruited during equally randomized or usual care. participants recorded symptoms monitored oxygen saturation, heart rate, peak expiratory flow, body weight. Alerts generated if readings...
Patients with chronic obstructive pulmonary disease (COPD) often experience severe physical limitations and psychological distress, which can lead to a deterioration in quality of life (QoL). Telemonitoring (TM) may improve QoL reduce the number hospitalizations readmissions, but results from previous studies have been conflicting. The aim this study was assess effect TM on patients moderate COPD recruited during hospitalization for acute exacerbation (AECOPD).We conducted randomized...
Abstract Background and objective Antifibrotic therapy with nintedanib or pirfenidone slows disease progression reduces mortality in patients idiopathic pulmonary fibrosis (IPF). However, advanced IPF, as defined by forced vital capacity (FVC) < 50% and/or diffusion for carbon monoxide (DLCO) 30% of predicted, have not been included randomized trials, the outcomes such who initiate treatment are well understood. We determined lung function, following initiation antifibrotic IPF at time...
Background and objective: To describe the clinical characteristics including bronchoalveolar lavage fluid (BALF) of patients with antisynthetase syndrome (AS) associated interstitial lung disease (ILD) in a tertiary ILD outpatient clinic, their medical therapy outcome. Methods: Retrospective cohort study AS-ILD. All available data characteristics, pulmonary function tests, laboratory parameters, BALF analysis, histology, high-resolution computed tomography (HRCT) treatment were collected...
To investigate incidence and prevalence of Systemic Sclerosis (SSc) association with interstitial lung disease (SSc-ILD) in a nationwide population-based study.Patients an incident diagnosis SSc 2000-2016 were identified the Danish National Patient Registry categorised based on ILD. Incidence- proportions calculated annual population estimates. A cox proportional hazards model was used to evaluate between age, sex, region marital status presence ILD.In total, 1869 patients identified; 275...
Abstract Background Comorbidities are common in interstitial lung diseases (ILD) and have an important association with survival, but the frequency prognostic impact of comorbidities unclassifiable disease (uILD) remains elusive. We aimed to describe prevalence assess on survival patients uILD. Furthermore, we identify characterize potential phenotypes based clusters examine their progression survival. Methods Incident diagnosed uILD were identified at two ILD referral centers Denmark...
At Silkeborg Regional Hospital, Denmark, the number of stage IA lung cancer increased after implementation use CT investigations and a corresponding reduction in chest X-ray. The aim present study was to understand changes referral pathways, patient characteristics imaging procedures behind observed increase early-stage cancer.The pathways for all patients diagnosed with 2013-2018 were described based on manually curated information from electronic health care systems staging Danish Lung...
Hypersensitivity pneumonitis (HP) is a complex pulmonary disorder mediated by the immune system and caused various inhaled antigens against which subject has previously been sensitized. In about 50% of cases, antigen not identified. Identification removal eliciting important for prognosis. We report two cases HP molds atypical mycobacteria isolated from wind instruments. present first case bassoon playing another in trombone. fungi bacteria instruments may be much more common than thought....
Pulmonary disease is a major cause of excess mortality among patients with rheumatoid arthritis (RA). Interstitial lung (ILD) feared complication, but the benefit screening unknown. The aim this study was to assess frequency pulmonary disease, including ILD, in early RA.Patients newly diagnosed RA were recruited prospectively at single centre and underwent systematic function tests (PFTs) computed tomography (CT) scans inclusion after two years.The included 150 (mean age 57 years, 63%...
ABSTRACT Background and objective Co‐morbidities are frequent among patients with interstitial lung diseases (ILD). The of this study was to investigate their impact on mortality. Methods We used the Danish National Patient Registry (DNPR) identify all a first‐time diagnosis ILD between 1998 2010. Patients were matched 1:4 controls from background population. burden co‐morbidity assessed using Deyo–Charlson score (DCcs). Mortality risks Kaplan–Meier survival curves, hazard rate ratios (HRR)...
Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease (ILD) with median survival of 3-5 years. The aim the present study was to evaluate severity and in patients diagnosed IPF era antifibrotic therapies compared an earlier cohort.We identified all fibrotic ILD hospital electronic case record system between 2011 2016, reviewed each order identify incident IPF. We used GAP-index compare mortality previous findings at our center 2003 2009.260 were 2016. Mean age 72.6 years,...
Extra-fine particle inhaled corticosteroids (ICS) improve peripheral airway distribution, but their effect on risk of exacerbations and all-cause mortality in patients with chronic obstructive pulmonary disease (COPD) is unclear.