A5043790278- Glioma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Innovations in Medical Education
- Advanced Electron Microscopy Techniques and Applications
- Caveolin-1 and cellular processes
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Diversity and Career in Medicine
- Perfectionism, Procrastination, Anxiety Studies
- Erythropoietin and Anemia Treatment
- RNA Research and Splicing
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Genetic Associations and Epidemiology
- Patient Satisfaction in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Patient-Provider Communication in Healthcare
- Neuroblastoma Research and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Neurofibromatosis and Schwannoma Cases
- Hemoglobinopathies and Related Disorders
Penn State Milton S. Hershey Medical Center
2019-2025
Pennsylvania State University
2019-2023
Kidney Associates
2021
Greater Baltimore Medical Center
1999
Immune responses to vaccination are a known trigger for new onset of glomerular disease or flare in susceptible individuals. Mass immunization against SARS-CoV-2 the COVID-19 pandemic provides unique opportunity study vaccination-associated autoimmune kidney diseases. In recent literature, there several patient reports demonstrating temporal association and
Iron is essential for normal brain development and function. Hence, understanding the mechanisms of iron efflux at blood-brain barrier their regulation are critical establishment homeostasis. Here, we have investigated role exosomes in mediating transfer H-ferritin (FTH1)- or transferrin (Tf)-bound across endothelial cells (BBBECs). Our study used ECs derived from human-induced pluripotent stem that grown bicameral chambers. When were exposed to 55Fe-Tf 55Fe-FTH1, 55Fe activity exosome...
Abstract Transcriptome-wide association studies (TWAS) are popular approaches to test for between imputed gene expression levels and traits of interest. Here, we propose an integrative method PUMICE (Prediction Using Models Informed by Chromatin conformations Epigenomics) integrate 3D genomic epigenomic data with quantitative trait loci (eQTL) more accurately predict expressions. helps define prioritize regions that harbor cis-regulatory variants, which outperforms competing methods. We...
<h3>Importance</h3> The results of studies evaluating spinal cord stimulation (SCS) for postlaminectomy syndrome (PLS) have yielded mixed results. This has led to an increased emphasis on objective outcome measures such as opioid prescribing. <h3>Objective</h3> To determine the association between SCS and long-term therapy (LOT) PLS. <h3>Design, Setting, Participants</h3> In this cohort study, adults with PLS were identified using TriNetx Diamond Network separated based whether they...
Abstract Glioblastoma is one of the deadliest malignancies facing modern oncology today. The ability glioblastoma cells to diffusely spread into neighboring healthy brain makes complete surgical resection nearly impossible and contributes recurrent disease faced by most patients. Although research impact iron on has addressed proliferation, there been little investigation how cellular impacts migrate—a key question, especially in context diffuse observed these tumors. Herein, we show that...
Abstract The association between anemia and outcomes in glioblastoma patients is unclear. We analyzed data from 1346 histologically confirmed adult the TriNetX Research Network. Median hemoglobin hematocrit levels were quantified for 6 months following diagnosis used to classify as anemic or non-anemic. Associations of iron supplementation with median overall survival (median-OS) then studied. Among patients, 35.9% male 40.5% female classified using hemoglobin-based WHO guidelines. males,...
OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas that harbor a high potential for metastasis and have devastating prognosis. Combination chemoradiation aids in tumor control decreases recurrence but causes deleterious side effects does not extend long-term survival. An effective treatment with limited toxicity enhanced efficacy is critical patients suffering from MPNSTs. METHODS The authors recently identified interleukin-13 receptor alpha 2...
e14029 Background: Transition metals such as copper, iron, zinc, and manganese are known to play essential roles in human physiology evidenced conditions where these dysregulated. The role of transition glioblastoma biology has been largely understudied. Here we investigated whether plasma tumor metal content is associated with patient outcomes. Methods: was measured 31 samples, 21 which had matched using inductively coupled mass spectroscopy (ICP-MS) or atomic emission (ICP-AES)....
Abstract Glioblastoma (GBM) is an aggressive brain cancer that extremely difficult to treat. GBM sexually dimorphic in nature, where females are less susceptible developing GBM, respond therapy better, and get a survival advantage. Sex-biased differences tumor iron metabolism play significant part making this disease dimorphic. Macrophages constitute population the microenvironment key players homeostasis. Here, we examine macrophage homeostasis as potential driver of sex biases glioblastoma...
Abstract Glioblastoma (GBM) is an aggressive brain cancer that sexually dimorphic in nature, with females less susceptible to developing it, responding better therapy, and gaining a survival advantage. Iron metabolism also has been shown previously contribute sex bias GBM. Ferritin iron-storing protein elevated expression tumor cells essential GBM growth. Here, we used vivo model consisting of heterozygous FTH1 knockdown (FTH1-KD) mice GL261 study the role host ferritin progression. We have...
Patient engagement is increasing in the presence of digital patient assessment platforms, or physician rating websites. Despite this rapid growth, data remains insufficient regarding how these evaluations impact radiation oncologists.The purpose study was to assess oncologists worldwide on their awareness and noted effects platforms.An electronic survey delivered 6,199 members American Society Radiation Oncology. Subjects were practicing throughout world. The consisted 14 questions focused...
Abstract The tumor microenvironment (TME) in glioblastoma presents a significant hurdle to effective immunotherapies as it consists of an immunosuppressive niche that results inhibition anti-tumor immunity. Macrophages comprise large portion the TME they are prolific secretors cytokines and can up 30% volume. In addition their crucial role immune function, macrophages important players iron regulation owing ability efficiently sequester release iron. We studied impact status macrophage...
We report a 51-year-old man who presented with 3 weeks of polyarthritis fever, nonproductive cough, bibasilar crackles, tachypnea, and hypoxia. Initial laboratory data showed an increased erythrocyte sedimentation rate, rheumatoid factor, anti-Jo-1 antibody. Imaging studies bilateral lower lobe infiltrates the lung. A transbronchial biopsy specimen revealed characteristic findings for bronchiolitis obliterans organizing pneumonia (BOOP). About 6 months later, he developed profound proximal...
Background: Superior vena cava (SVC) syndrome may result from extravascular compression or intravascular obstruction such as thrombosis. Recurrent venous thrombosis is typically associated with a hypercoagulable state malignancy, and inheritable acquired coagulopathy. Sarcoidosis derangement of the immune system, it has been malignant diseases hypercoagulation. The association pancreatic cancer sarcoidosis SVC not reported previously. Here, we present case recurrent causing in patient ductal...
To the editor: Medical schools have launched programs to reduce students' length of training and debt burden, such as 3-year "accelerated" pathways tuition exemptions.1Leong S.L. Gillespie C. Jones B. et al.Accelerated MD pathway programs: graduates' perspectives on education quality, learning environment, residency readiness, debt, burnout, career plans.Acad Med. 2022; 97: 254-261https://doi.org/10.1097/ACM.0000000000004332Crossref PubMed Scopus (1) Google Scholar,2Hopkins Tanne J. New York...