A5102828587- Inflammatory Biomarkers in Disease Prognosis
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Bone health and treatments
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Body Contouring and Surgery
- Chemokine receptors and signaling
- Metastasis and carcinoma case studies
- Insect Utilization and Effects
- Forensic Entomology and Diptera Studies
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Lymphatic Disorders and Treatments
- Insect and Pesticide Research
First Affiliated Hospital of Dalian Medical University
2009-2023
Dalian Medical University
2009-2023
Tokyo Medical University
2006-2009
Kasumigaura Medical Center
2009
Maggots (larvae of Lucilia sericata) have shown therapeutic effects on refractory wounds infected with bacteria, yet the bacterial killing mechanisms are unclear. Herein, we report isolation and purification an antibacterial protein from maggots (MAMP). MAMP demonstrated inhibitory activity against both standard strains clinically isolated antibiotic-resistant Staphylococcus aureus in vitro. The topical use effectively decreased viability S. promoted wound healing mouse skin infection model....
Patients with the most common advanced human cancers such as lung, breast, uterus, and of digestive system almost always develop bone metastases, painful untreatable consequences. This study aimed to determine prognostic implications neutrophil/lymphocyte (N/L) ratio in peripheral blood patients malignant metastasis. Study participants were identified from a prospective cohort cancer Data for N/L ratios obtained clinical pathological records analyzed together other known factors multivariate...
Objective Colorectal cancer (CRC) is a prevalent gastrointestinal tumor globally. Circular RNAs (circRNAs) have been identified as regulatory players in the pathogenesis of CRC. However, it unclear whether hsa_circ_0050102 (circPGPEP1) affects malignant progression and immune escape
Cytokines exhibit a pleiotropic effect in the regulation of immune cell function, tumor growth and antitumor responses. A total 30 patients with colorectal carcinoma were enrolled on this study their levels interleukin (IL)-1β, IL-6, IL-8, necrosis factor (TNF)-α, serum granulocyte colony-stimulating (sG-CSF) macrophage (sM-CSF) measured preoperatively using ELISA. Tumor-infiltrating (TIG), tumor-associated (TAM), G-CSF M-CSF expression cells examined immunostaining. This revealed abnormal...
Targeted therapies have been proven as promising in the treatment of breast cancer and improved survival quality life advanced cancer. We previously identified a novel peptide SA12 which showed significant activity inhibition proliferation induction apoptosis SKBr-3 cells.The present study investigated potential antitumor role cell lines MDA-MB-231 MCF-7 through Cell Counting Kit-8 assay colony formation assay, examined cycle distribution using flow cytometry analysis. Furthermore,...
In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with tumor load. The objective of present study was to determine implications chemotherapy effect by fluctuations N/L ratio in patients unresectable or recurrent gastric cancer. participants were identified from a prospective cohort (n=135). median 3.23 (range: 0.76-20.45) prior (pre-chemo-N/L ratio) 2.55 1.17-13.45) following 2-4 weeks when completed (post-chemo-N/L ratio), respectively. overall...
Purpose In recent years, total neoadjuvant therapy (TNT) has emerged as a new therapeutic strategy against advanced rectal cancer (RC). After administration of TNT, some patients show complete clinical response (cCR) to treatment however, disputes about the effects TNT and alternative plans in case recurrence after cCR still exist. Methods A 100 were included this paper. CR non-CR was observed when these administered with at First Affiliated Hospital Dalian Medical University, China from May...