A5048458636- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Advanced biosensing and bioanalysis techniques
- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Diet and metabolism studies
- Ginseng Biological Effects and Applications
- Diet, Metabolism, and Disease
- Traditional Chinese Medicine Studies
- 3D Printing in Biomedical Research
- Neurological Disease Mechanisms and Treatments
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Medical Imaging and Pathology Studies
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Pharmacological Effects of Natural Compounds
Guangzhou University of Chinese Medicine
2016-2025
The University of Queensland
2015-2024
Jiangsu University
2024
Chinese PLA General Hospital
2024
Mudanjiang Medical University
2023
Weifang Chinese Medicine Hospital
2021
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2021
China Academy of Chinese Medical Sciences
2021
Xiyuan Hospital
2021
Xi'an Honghui Hospital
2020
The islet is an important endocrine organ to secrete insulin regulate the metabolism of glucose and maintain stability blood glucose. Long noncoding RNAs (lncRNAs) are involved in a variety biological functions play key roles many diseases, including type 2 diabetes (T2D). aim this study was determine whether lncRNA-p3134 associated with signaling pancreatic β cells.LncRNA microarray technology used identify differentially expressed circulating lncRNAs T2D patients. RT-PCR analyses were...
Abstract Epithelial–mesenchymal transition (EMT) is a primary mechanism for cancer metastasis. Detecting the activation of EMT can potentially convey signs metastasis to guide treatment management and improve patient survival. One classic signatures characterized by dynamic changes in cellular expression levels E‐cadherin N‐cadherin, whose soluble active fragments have recently been reported be biomarkers diagnosis prognosis. Herein, microfluidic immunoassay (termed “SERS immunoassay”) based...
Immune checkpoint blockade (ICB) therapy has achieved remarkable success in many cancers including melanoma. However, ICB benefits only a small proportion of patients and produces severe side effects for some patients. Thus, there is an urgent need to identify who are more likely respond improve outcomes minimize effects. To predict responses, we design surface-enhanced Raman scattering (SERS) assay multiplex profiling circulating tumor cells (CTCs) under basal interferon-γ (IFN-γ)...
Abstract Glycosylation is the most common post‐translational modification of proteins and regulates a myriad fundamental biological processes under normal, pathological conditions. Altered protein glycosylation linked to malignant transformation, showing distinct glycopatterns that are associated with cancer initiation progression by regulating tumor proliferation, invasion, metastasis, therapeutic resistance. The small extracellular vesicles (sEVs) released cells promising candidates for...
Diabetes is commonly associated with liver lipid metabolism disorders. AMP-activated protein kinase (AMPK) has a key role in regulating metabolism. Grape seed procyanidin B2 (GSPB2), natural polyphenol polymer, ameliorates mitochondrial dysfunction and inhibits oxidative stress or apoptosis via AMPK pathways. In the present study, hypothesis that GSPB2 treatment may ameliorate metabolic disorders by activating downstream pathways was tested diabetic mice. Db/m mice were used as controls,...
Epithelial to mesenchymal transition (EMT) results in the genesis of circulating tumor cells (CTCs) from sites and promotes metastatic capability CTCs circulation. In this study, we develop a multiplex surface-enhanced Raman scattering nanotechnology for comprehensive characterization EMT-associated phenotypes CTCs, monitor cancer metastasis. We observe downregulation CTC marker (EpCAM) epithelial (E-cadherin), as well upregulation (N-cadherin) stem cell (ABCB5) during transforming growth...
Background . Alzheimer’s disease (AD) is a chronic progressive neurodegenerative disease; however, there are no comprehensive therapeutic interventions. Therefore, this study aimed at identifying novel molecular targets that may improve the diagnosis and treatment of patients with AD. Methods In our study, GSE5281 microarray dataset from GEO database was collected screened for differential expression analysis. Genes P value <0.05 ∣log2FoldChange | >0.5 were considered differentially...
The aim of this study is to analyze the effects acupuncture on peripheral immune function, inflammation, and cognitive impairment in vascular dementia (VD) rats.In study, 2-month-old healthy male Wistar rats (260-280 g) were assigned groups as follows: normal group (Gn, n = 10), sham-operated (Gs, operated (Go, 45). Go was established by permanent, bilateral common carotid artery occlusion (BCCAO). Two months after operation, screened hidden platform trial with dysfunction further randomly...
Melanoma continues to be a leading cause of mortality among skin cancers. Despite advancements in targeted therapy, patients frequently develop resistance, disease progression within year. This resistance may result from the epithelial-to-mesenchymal transition (EMT)-like phenotype switching melanoma cells. Tracking EMT-related phenotypic changes on extracellular vesicles (EVs) has potential inform early about response therapy and progression. However, knowledge protein biomarkers carried by...
One of human GLP-1 analogues, liraglutide has been approved as adjuvant therapy to oral medication in T2DM. It was also shown prevent diabetes obese subjects and rats. However, it is unknown whether can effectively mitigate the effects prediabetes. We therefore investigate this by treating 12-weeks old Otsuka-Long-Evans-Tokushima fatty (OLETF) rats with 50, 100, 200 μg/kg, respectively twice a day for 12 weeks. Eight Long-Evans-Tokushima-Otsuka (LETO) saline injection served normal controls....
This study investigated the effects of blockade IL-6 on bone loss induced by modeled microgravity (MG). Adult male mice were exposed to hind-limb suspension (HLS) and treated with IL-6-neutralizing antibody (IL-6 nAb) for 4 weeks. HLS in led upregulation expression both sera femurs. nAb treatment significantly alleviated loss, evidenced increased mineral density whole tibia, trabecular thickness number, volume fraction proximal tibiae, ultimate load stiffness femoral diaphysis. enhanced...
Abstract Microglia are a specialized population of innate immune cells located in the central nervous system. In response to physiological and pathological changes their microenvironment, microglia can polarize into pro‐inflammatory or anti‐inflammatory phenotypes. A dysregulation pro‐/anti‐inflammatory balance is associated with many pathophysiological brain Therefore, between polarization be potential biomarker for various pathologies. non‐invasive method detecting patients would have...
Huzhentongfeng (HZTF) is an extract from four Chinese medical herbs for treating gout. This study aims to evaluate its antigout activity and preliminary explore mechanism in vivo vitro.The rats were intragastrically administered with HZTF 5 days then injected 0.1 ml (10 mg) of MSU crystals their joints generating a gout model analyze the paw volume histopathology joint synovial tissues different doses. We also investigated antioxidant capacity vitro using indication including lipid...
Background: Vascular dementia (VD) is the second most common type of after Alzheimer's disease, but there a lack definitive treatment for VD. Acupuncture effective in improving cognitive impairment and behavioral capacity patients with In recent years, more studies indicated that peripheral inflammation abnormal immune function may aggravate neuroinflammation dysfunction. However, are few about acupuncture Also, concern regulating effect on immunity Objective: The aim this study was to...