A5013698121- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Bone and Joint Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Peripheral Neuropathies and Disorders
- Ultrasound Imaging and Elastography
- Neurogenesis and neuroplasticity mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Rheumatoid Arthritis Research and Therapies
- Radiopharmaceutical Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- Sphingolipid Metabolism and Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Reproductive System and Pregnancy
- Medical Imaging Techniques and Applications
- Immune Response and Inflammation
- MRI in cancer diagnosis
- Acute Myocardial Infarction Research
- Infrared Thermography in Medicine
- Alzheimer's disease research and treatments
Massachusetts General Hospital
2019-2025
Harvard University
2019-2025
Athinoula A. Martinos Center for Biomedical Imaging
2019-2025
Don Carlo Gnocchi Foundation
2023
Sapienza University of Rome
2011-2022
University of Campania "Luigi Vanvitelli"
2020
Ospedale Sant'Anna
2020
Azienda Ospedaliera Sant'Andrea
2016
CTO Andrea Alesini
2015
Queen Mary University of London
2015
To test the effect of oral contraceptives (OCs) in combination with interferon β (IFN-β) on disease activity patients relapsing-remitting multiple sclerosis (RRMS).One hundred fifty women RRMS were randomized a 1:1:1 ratio to receive IFN-β-1a subcutaneously (SC) only (group 1), SC plus ethinylstradiol 20 μg and desogestrel 150 2), or ethinylestradiol 40 125 3). The primary endpoint was cumulative number combined unique active (CUA) lesions brain MRI at week 96. Secondary endpoints included...
Abstract In multiple sclerosis, individual lesion-type patterns on magnetic resonance imaging might be valuable for predicting clinical outcome and monitoring treatment effects. Neuropathological studies consistently show that cortical lesions contribute to disease progression. The presence of chronic active white matter harbouring a paramagnetic rim susceptibility-weighted has also been associated with an aggressive form sclerosis. It is, however, still uncertain how these two types relate...
Compartmentalized meningeal inflammation is thought to represent one of the key players in pathogenesis cortical demyelination multiple sclerosis. PET targeting 18 kDa mitochondrial translocator protein (TSPO) a molecular-specific approach quantifying immune cell-mediated density cortico-meningeal tissue compartment vivo. This study aimed characterize and TSPO expression heterogeneous cohort sclerosis cases using vivo simultaneous MR-PET with 11C-PBR28, second-generation radioligand, ex...
Objective: The objective of this paper is to investigate four-year outcomes interferon beta (IFNB)-treated patients with multiple sclerosis (MS) according their clinical or magnetic resonance imaging (MRI) activity status at first year treatment. Methods: A total 370 MS duration ≤5 years before IFNB start were followed-up for four years. optimal threshold one-year MRI that more accurately predicted subsequent relapses disability worsening was identified. risk and after the then estimated by...
Prolonged dual antiplatelet therapy after 12 months in patients with previous myocardial infarction (MI) is attractive to reduce long-term ischemic complications. In the PEGASUS-TIMI 54, use of low-dose ticagrelor (60 mg b.i.d.) plus aspirin from MI reduced risk events, at price limited increase on bleeding However, data real-world practice lack. We aim providing prescription/eligibility criteria and outcomes receiving setting. enrolled consecutive eligible for 60 according Italian national...
Abstract We used 7 T MRI to: (i) characterize the grey and white matter pathology in cervical spinal cord of patients with early relapsing-remitting secondary progressive multiple sclerosis; (ii) assess lesion spatial distribution hypothesis an outside-in pathological process possibly driven by CSF-mediated immune cytotoxic factors; (iii) evaluate association brain burden its contribution to neurological disability. prospectively recruited 20 relapsing-remitting, 15 sclerosis participants 11...
Background: Paramagnetic rim white matter (WM) lesions (PRL) are thought to be a main driver of non-relapsing multiple sclerosis (MS) progression. It is unknown whether cerebrospinal fluid (CSF)-soluble factors diffusing from the ventricles contribute PRL formation. Objective: To investigate distribution and non-rim brain WM as function distance ventricular CSF, their relationship with cortical lesions, contribution lesion phenotype, localization neurological disability. Methods: Lesion...
Thalamic pathology is a marker for neurodegeneration and multiple sclerosis (MS) disease progression.To characterize (1) the morphology of thalamic lesions, (2) their relation to cortical white matter (WM) (3) clinical measures, assess (4) imaging correlates atrophy.A total 90 MS patients 44 healthy controls underwent acquisition 7 Tesla images lesion segmentation 3 scans atrophy evaluation. lesions were classified according shape presence central venule. Regression analysis identified...
To date, the relationship between central hallmarks of multiple sclerosis (MS), such as white matter (WM)/cortical demyelinated lesions and cortical gray atrophy, remains unclear. We investigated interplay atrophy individual lesion-type patterns that have recently emerged new radiological markers MS disease progression. employed a machine learning model to predict mean thinning in whole-brain single hemispheres 150 regions using demographic lesion-related characteristics, evaluated via an...
Few studies have examined behavioural changes in the early phase of multiple sclerosis (MS). The aim study is to investigate mood alterations and explore coping strategies regarding patients with clinically isolated syndrome (CIS) relapsing-remitting MS (RRMS).The communication diagnosis was made by one neurologist using a standardized approach. Depression, anxiety questionnaires were filled within 1 month from at 3, 6, 12, 18 24 months subsequently.Thirty-nine (11 CIS, 28 RRMS), also 39...
Axonal degeneration is a central pathological feature of multiple sclerosis and closely associated with irreversible clinical disability. Current noninvasive methods to detect axonal damage in vivo are limited their specificity applicability, by the lack proper validation. We aimed validate an MRI framework based on multicompartment modeling diffusion signal (AxCaliber) rats presence pathology, achieved through injection neurotoxin damaging neuronal terminal axons. then applied same protocol...
Background: 11 C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is optimal marker exists. Objectives: To investigate ability PET PRL assessment to identify inflammation in white matter (WM) their relation neurological impairment. Methods: Based uptake, brain WM from 30 patients were classified active or inactive. The presence was...
Activated microglia, which can be detected in vivo by 11C-PBR28 positron emission tomography (PET), represent a main component of MS pathology the brain. Their role cerebellum is still unexplored, although cerebellar involvement frequent and accounts for disability progression.We aimed at characterizing neuroinflammation patients compared to healthy subjects combining MRI-Positron Emission Tomography (MR-PET) with 7 Tesla (T) MRI assessing its relationship brain clinical outcome...
In daily clinical setting, some patients affected by relapsing-remitting Multiple Sclerosis (RRMS) are switched from the low-dose to high-dose Interferon beta (IFNB) in order achieve a better control of disease.In this observational, post-marketing study we reported 2-year outcomes IFNB; also evaluated whether different criteria adopted switch had an influence on outcomes.Patients RRMS and IFNB due occurrence relapses, or contrast-enhancing lesions (CELs) as detected yearly scheduled MRI...
Background . The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. aim this work was to investigate the relationship between PRL plasma levels brain damage as measured by magnetic resonance imaging (MRI). Methods We employed a chemiluminescence immunoassay for measuring PRL. used 1.5 T scanner acquire images Jim 4.0 SIENAX software analyse them. Results included 106 women with relapsing remitting (RR) MS stable disease last two months....
Cortical demyelination occurs early in multiple sclerosis (MS) and relates to disease outcome. The brain cortex has endogenous propensity for remyelination as proven from histopathology study. In this study, we aimed at characterizing cortical microstructural abnormalities related myelin content by applying a novel quantitative MRI technique MS. A combined estimation (CME) map was obtained 7-Tesla (7T) T <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:msubsup><mml:mrow...
Traditional techniques based on diffusion MR imaging suffer from extremely low specificity in separating disease-related alterations white matter microstructure, which can involve multiple phenomena including axonal loss, demyelination and changes size. Multi-shell MRI is able to greatly increase by concomitantly exploring timescales. If multi-shell acquisition combined with an exploration of different times, data allows the estimation sophisticated compartmental models, provide enhanced...