A5071365159- Reproductive System and Pregnancy
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and genetic disorders
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Neonatal Respiratory Health Research
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Fetal and Pediatric Neurological Disorders
- MicroRNA in disease regulation
- Cerebral Palsy and Movement Disorders
- Preterm Birth and Chorioamnionitis
- Cardiovascular Issues in Pregnancy
- Moyamoya disease diagnosis and treatment
- RNA modifications and cancer
- Pregnancy and Medication Impact
- Connective tissue disorders research
- Cerebral Venous Sinus Thrombosis
- Endometriosis Research and Treatment
- Microtubule and mitosis dynamics
- Multiple Sclerosis Research Studies
- Family Support in Illness
University of California, San Francisco
2014-2024
Harvard University
2022-2024
Brigham and Women's Hospital
2022-2023
Massachusetts General Hospital
2022-2023
Northwestern University
2023
University of Pennsylvania
2023
Broad Center
2014-2016
University of California San Francisco Medical Center
2014
ABSTRACT In utero infection and maternal inflammation can adversely impact fetal brain development. Maternal systemic illness, even in the absence of direct infection, is associated with an increased risk neuropsychiatric disorders affected offspring. The cell types mediating response to are largely unknown, hindering development novel treatment strategies. Here, we show that microglia, resident phagocytes brain, highly express receptors for relevant pathogens cytokines throughout embryonic...
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance neural stem cells in fetal brain called outer radial glia (oRG). oRG display characteristic division mode, mitotic somal translocation (MST), which soma rapidly translocates toward cortical plate immediately prior cytokinesis. MST may be essential for progenitor zone expansion, but mechanism unknown, hindering exploration its function development and disease. Here, we show that requires activation...
Patients with multiple sclerosis (MS) may seek fertility treatment (FT)-including in vitro fertilization (IVF). Variable relapse risk after IVF has been reported small historical cohorts, more recent studies suggesting no change annualized rate (ARR). The objective of this study was to evaluate ARR 12 months pre-FT and 3 post-FT a multicenter cohort identify factors associated an increased relapse.Patients clinically isolated syndrome (CIS) or MS aged 18-45 years at least 1 FT from January...
Abstract Background Preterm white matter injury (PWMI) is the most common cause of brain in premature neonates. PWMI involves a differentiation arrest oligodendrocytes, myelinating cells central nervous system. Clemastine was previously shown to induce oligodendrocyte and myelination mouse models at dose 10 mg/kg/day. The minimum effective (MED) clemastine unknown. Identification MED essential for maximizing safety efficacy neonatal clinical trials. We hypothesized that mice lower than...
Preterm white matter injury (PWMI) is the most common cause of brain in premature neonates. PWMI involves a differentiation arrest oligodendrocytes, myelinating cells central nervous system. Clemastine was previously shown to induce oligodendrocyte and myelination mouse models at dose 10 mg/kg/day. The minimum effective (MED) clemastine unknown. Identification if MED essential for maximizing safety efficacy neonatal clinical trials. We hypothesized that mice lower than
ABSTRACT In utero infection and maternal inflammation can adversely impact fetal brain development. Maternal systemic illness, even in the absence of direct central nervous system infection, is associated with an increased risk autism schizophrenia affected offspring. The cell types mediating response to are largely unknown, hindering development therapies prevent treat adverse neuropsychiatric outcomes. Here, we show that microglia, resident phagocytes brain, enriched for expression...
The effects of pregnancy on multiple sclerosis (MS) inflammatory activity are not well described in women with moderate to severe disabilities.To quantify the peripartum annualized relapse rate (ARR) MS an Expanded Disability Status Scale (EDSS) ≥ 3.We performed a retrospective cohort study 85 pregnancies 74 subjects preconception EDSS 3. We quantified ARR and tested for risk factors predictive relapses, postpartum brain magnetic resonance imaging (new T2 or gadolinium-enhancing lesions),...
Maternal immune activation can affect the development of embryos, but underlying mechanisms have been unclear. In a new study, Bridget Ostrem and colleagues show that embryonic microglia detect maternal inflammation, resulting in transcriptional changes neighbouring brain-cell types. To find out more about behind paper story, we caught up with first authors, Nuria Domínguez-Iturza, corresponding author Paola Arlotta, Chair Department Stem Cell Regenerative Biology at Harvard University, USA.
May 6, 2019April 9, 2019Free AccessMonogenic Causes of Cerebrovascular Disease in Childhood (P2.3-057)Bridget Ostrem, Paul Caruso, Eric Grabowski, and Patricia MusolinoAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P2.3-057 Letters to the Editor