A5100634289- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Plant tissue culture and regeneration
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Renal cell carcinoma treatment
- Monoclonal and Polyclonal Antibodies Research
- Microscopic Colitis
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Transgenic Plants and Applications
- Heat shock proteins research
- IgG4-Related and Inflammatory Diseases
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
University of Ulsan
2011-2024
Asan Medical Center
2014-2024
Ulsan College
2014-2024
Seoul National University Bundang Hospital
2018-2024
Korea University
2019-2022
Korea Research Institute of Bioscience and Biotechnology
2013-2021
Case Western Reserve University
2020
Korea University of Science and Technology
2015-2017
Sungkyunkwan University
2007
Samsung (South Korea)
2007
Colorectal cancer (CRC) is the third most common form of and poses a critical public health threat due to global spread westernized diets high in meat, cholesterol, fat. Although link between diet colorectal has been well established, mediating role gut microbiota remains elusive. In this study, we sought elucidate connection microbiota, diet, CRC through metagenomic analysis bacteria isolated from stool (n = 89) healthy 161) subjects. This yielded dozen genera that were significantly...
// Young Soo Park 1, 5 , Dong Joon Kim 2 Han Koo 2, Se Hwan Jang 3 Yeon-Mi You Jung Hee Cho Suk-Jin Yang 1 Eun Sil Yu 4 Yuri Chul Lee Jung-Ae Zee-Yong Kyung Chan Il Yeom Biotherapeutics Translational Research Center, Korea Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Personalized Genomic Medicine School Life Sciences, Gwangju Science and Technology, 61005, Department Pathology, Asan Medical University Ulsan College Medicine, Seoul 05505, Functional Genomics, 34113,...
Nivolumab plus chemotherapy in the first-line setting has demonstrated clinical efficacy patients with human epidermal growth factor receptor 2-negative advanced or metastatic gastric cancer, and is currently indicated as a standard treatment. Programmed death-ligand 1 (PD-L1) expression an important biomarker for predicting response to anti-programmed death 1/PD-L1 agents several solid tumors, including cancer. In CheckMate-649 trial, significant improvements were observed PD-L1 combined...
Abstract Objectives Oncogenic alterations of epidermal growth factor receptor (EGFR) signaling are frequently noted in non‐small cell lung cancer (NSCLC). In recent decades, EGFR tyrosine kinase inhibitors (TKIs) have been developed, although the therapeutic efficacy these inhibitor is restricted to EGFR‐mutant patients. this study, we investigated that clathrin‐mediated endocytosis hampers effects gefitinib and sustains NSCLC cells with wild‐type EGFR. Materials Methods lines (H358, Calu‐3,...
Cigarette smoke (CS) affects the expression of microRNAs (miRNAs), which are important regulators gene by inducing DNA methylation. However, effects smoking on miRNA have not been fully elucidated in smoking-related lung carcinogenesis. Therefore, this study, to investigate change pattern and identify tumor suppressor miRNAs carcinogenesis, we used carcinogenesis model cell lines that, derived from a murine xenograft with human bronchial epithelial cells (BEAS-2B), exposed CS or not. The...
Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated (TMAP), is a novel that frequently upregulated in various malignances. However, its cellular functions remain unknown. A previous study has shown level begins to increase during G(1)/S and peaks at G(2)/M, after which it decreases abruptly. Ectopic overexpression of TMAP/CKAP2 induced microtubule bundling related increased stability. resulted cell cycle arrest mitosis due defect centrosome...
Everolimus (RAD001) is an orally administered mTOR inhibitor that well known for its antitumor efficacy and has been approved the treatment of several solid tumors, including renal cell carcinoma. In gastric cancer (GC), despite previous preclinical phase I/II studies suggesting promising everolimus in previously treated AGC, more recent trials revealed only certain subsets patients might benefit from with everolimus. A 26-year-old man metastatic multiple liver lesions was after failure...
Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with metabolic rewiring cancer cells, and considered an important therapeutic target. Herein, we report novel PKM2 activator, PA-12, which was identified via molecular docking-based virtual screening. We demonstrate that PA-12 stimulates pyruvate activity recombinant vitro, half-maximal concentration 4.92 μM, effectively suppresses both anchorage-dependent -independent growth...
Background & Aims: The application of circulating tumor DNA (ctDNA) has been studied for predicting recurrent disease after surgery and treatment response during systemic treatment. Metastasectomy can be curative well-selected patients with metastatic colorectal cancer (mCRC). This prospective study investigated the ctDNA level before metastasectomy in mCRC to explore its potential as a predictive biomarker. Methods: We collected data on 98 metastasectomies performed from March 2017...
Kim, You Jae MD*; Park, Young Soo MD†; Koo, Bon San So, Min Wook Yong-Gil MD, PhD*; Lee, Chang-Keun Yoo, Bin PhD* Author Information
This study aimed to identify novel biomarkers for metastatic colorectal cancer progression using exosomal RNA expression profiling. The profiles of 54 patients with mCRC were investigated. Exosomal profiling was performed at the time relapse immediately before metastasectomy and recurrence or after metastasectomy. up- down-regulated screened analyzed H-cluster, principle component analysis gene ontology. tissue profile liver metastases compared GSE 41258 set GSEA tools. We identified two...
Circulating cell-free DNA (cfDNA) can be used to characterize tumor genomes through next-generation sequencing (NGS)-based approaches. We aim identify novel genetic alterations associated with drug resistance in lung cancer and colorectal patients who were treated EGFR-targeted therapy cytotoxic chemotherapy whole exome (WES) of cfDNA. A cohort 18 was EGFR TKI or chemotherapy, a 37 monoclonal antibody alone. Serum samples drawn before after development resistance, the mutational profile...
Insulin-like growth factor-1 receptor (IGF-1R), an important factor in promoting cancer cell and survival, is commonly upregulated cells. However, amplification of the IGF1R gene extremely rare tumors. Here, we have provided insights into mechanisms underlying regulation IGF-1R protein expression. We found that PKM2 serves as a non-metabolic binds to increases expression by interaction between heat-shock 90 (HSP90). depletion decreases HSP90 binding precursor, thereby reducing precursor...
Endoscopy remains the gold standard for evaluating mucosal healing in ulcerative colitis. However, given its invasiveness and high cost, it is not always possible to perform as often. This study aimed evaluate value of numerous patient-reported symptoms prediction endoscopic healing.We prospectively conducted a cohort involving 143 patients with colitis (men: 63.6%, median age: 40.0 years) tertiary teaching hospital between May 2017 2020. Clinical remission was defined resolution rectal...
Background: Although immunomodulators are widely prescribed in patients with Crohn’s disease (CD), it is unclear whether there a difference treatment outcomes between thiopurines and methotrexate (MTX). Objective: To compare the risk of clinical failure MTX bio-naïve CD. Design: Nationwide, population-based study. Methods: We used claims data from Korean National Health Insurance Service. After inverse probability weighting, logistic regression Cox proportional hazard analyses were to...
The proposed eosinophilic esophagitis (EoE) endoscopic reference score serves to diagnose and evaluate treatment responses in EoE. Nevertheless, the validated thresholds for diagnosis response Asian patients are yet be established. This study aims establish these first time among with