A5027473085- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Workplace Health and Well-being
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Tracheal and airway disorders
- Inflammatory mediators and NSAID effects
Ulsan College
2016-2025
Asan Medical Center
2016-2025
University of Ulsan
2016-2025
TiVo (United States)
2024
Kyung Hee University Medical Center
2024
Keimyung University
2008-2023
Chonbuk National University Hospital
2014
Ulsan University Hospital
2012-2013
Good Samaritan Hospital
2010
Korea University
2008
Association between Job Stress and Insomnia in Korean Workers: Hwan‐Cheol Kim, et al. Department of Occupational Environmental Medicine, Inha University Hospital, Korea— Objective We investigated the association job stress insomnia a large nationwide samples workers. Methods In this cross‐sectional study, total 8,155 workers from sample were recruited. surveyed subjects' sociodemographic work‐related characteristics seven subscales occupational using Scale Short Form. Each was dichotomized...
The progressive fibrosing (PF) phenotype of interstitial lung disease (ILD) is characterised by worsening respiratory symptoms, function, and extent fibrosis on high-resolution computed tomography. We aimed to investigate the prevalence clinical outcomes PF-ILD in a real-world cohort assess prognostic significance diagnostic criteria.Clinical data patients with ILD other than idiopathic pulmonary (IPF) consecutively diagnosed at single centre were retrospectively reviewed. A PF was defined...
Little is known about the standard care of small (<2 cm in diameter) pancreatic neuroendocrine tumors (PNET). The aim present study was to determine clinical outcomes PNET after endoscopic ultrasound (EUS)-guided ethanol-lipiodol ablation (EUS-ELA).In this prospective cohort study, consecutive patients who underwent EUS-ELA for were enrolled and followed ≥3 years. Treatment efficacy primary outcome measure.In total, 33 had 40 pathologically confirmed final analysis. A total 63 sessions...
Mismatch repair (MMR)-deficient and DNA polymerase epsilon (
Diffuse large B-cell lymphoma (DLBCL) is classified into prognostically distinct germinal center (GCB) and activated subtypes by gene expression profiling (GEP). Recent reports suggest the role of GEP in targeted therapy. Immunohistochemistry (IHC) algorithms have been proposed as surrogates GEP, but their utility remains controversial. Using microarray, we examined concordance 4 GEP-correlated 2 non-GEP-correlated IHC 381 DLBCLs, not otherwise specified. Subtypes variants DLBCL were...
The gastrointestinal tract is the most common primary extranodal site for diffuse large B-cell lymphoma (DLBCL).However, there no consensus on appropriate staging system intestinal DLBCL.We evaluated utility of modified Ann Arbor system, Lugano and Paris (a modification Tumor, Node, Metastases [TNM] epithelial tumors) in 66 cases resected DLBCL.The were treated with surgery, plus either cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) chemotherapy alone (n = 26) or addition...
Objectives There is an increasing need for grading with small endoscopic ultrasound–guided fine needle aspiration biopsy (EUS-FNAB) specimens the proper diagnosis and therapy selection of patients unresectable pancreatic neuroendocrine tumors (PanNET). However, our understanding EUS-FNAB specimen limited compared surgically resected specimens. Methods We retrospectively determined Ki-67 labeling index (LI) 33 matched PanNETs digital image analyzer. Pairwise grades between PanNET were...
This study aimed to develop a deep learning (DL) model for predicting the recurrence risk of lung adenocarcinoma (LUAD) based on its histopathological features. Clinicopathological data and whole slide images from 164 LUAD cases were collected used train DL models with an ImageNet pre-trained efficientnet-b2 architecture, densenet201, resnet152. The trained classify each image patch into high-risk or low-risk groups, case-level result was determined by multiple instance final FC layer's...
Non-small cell lung cancer (NSCLC) is histologically classified into adenocarcinoma (LUAD) and squamous carcinoma (LSCC). However, some tumors are ambiguous other pathophysiological features or microenvironmental factors may be more prominent. Here we report integrative multiomics analyses using data for 229 patients from a Korean NSCLC cohort 462 previous studies. Histological examination reveals five molecular subtypes, one of which subtype with PI3K-Akt pathway upregulation, showing high...
Conventional chemotherapeutics exploit cancer hallmark of active cell cycling, primarily targeting mitotic cells. Consequently, the index (MI), representing proportion cells in mitosis, serves as both a prognostic biomarker for progression and predictive marker chemo-responsiveness. In this study, we developed transcriptome signature to predict chemotherapeutic responsiveness based on Active Mitosis Signature Enrichment Score (AMSES), computational metric previously established estimate...
Abstract Background Immunoglobulin G4-related lung disease (IgG4-RLD) is the pulmonary manifestation of a systemic fibroinflammatory characterized by lymphoplasmacytic infiltration with an abundance IgG4-positive plasma cells. Long-term clinical course and outcomes IgG4-RLD remain unclear. We aimed to identify characteristics, treatment outcomes, longitudinal function changes in patients according radiologic classification. Methods Chest computed tomography findings 37 subjects were...
Vascular endothelial growth factor tyrosine kinase inhibitors (TKIs) have been the standard of care for advanced and metastatic clear cell renal carcinoma (ccRCC). However, therapeutic effect TKI monotherapy remains unsatisfactory given high rates acquired resistance to therapy despite favorable initial tumor response.
Abstract Background and Aims Heart failure (HF) remains a significant clinical challenge due to its diverse aetiologies complex pathophysiology. The molecular alterations specific distinct cell types histological patterns during HF progression are still poorly characterized. This study aimed explore cell-type- histology-specific gene expression profiles in cardiomyopathies. Methods Ninety tissue cores from 44 participants, encompassing various forms of cardiomyopathy control samples with...
B-cell activating factor of the tumor necrosis family (BAFF) and a proliferation-inducing ligand (APRIL) regulate survival proliferation B cells. Thus association elevated serum levels BAFF APRIL with worse prognosis has been suggested in lymphoid malignancies. However, prognostic relevance is unknown patients treated rituximab, monoclonal antibody targeting depletion.We measured by enzyme-linked immunosorbent assay 66 newly diagnosed as diffuse large lymphoma (DLBCL). All were...
The role of 90K and galectin-3 in cell-to-extracellular matrix adhesion tumor metastasis has been reported, but little is known about their the prognosis extranodal involvement diffuse large B-cell lymphomas (DLBCL). Thus, we measured serum concentration by enzyme-linked immunosorbent assay tissue expression immunohistochemistry newly diagnosed DLBCL patients. mean was higher than healthy controls (1,408.81 ± 89.45 vs. 980.94 58.69 ng/ml, p = 0.036). High (median value ≥1,249.50 ng/ml) high...