A5051120729- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Chromosomal and Genetic Variations
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Gene expression and cancer classification
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Cancer-related Molecular Pathways
Kyung Hee University
2021-2024
Kyung Hee University Medical Center
2024
Non-small cell lung cancer (NSCLC) is histologically classified into adenocarcinoma (LUAD) and squamous carcinoma (LSCC). However, some tumors are ambiguous other pathophysiological features or microenvironmental factors may be more prominent. Here we report integrative multiomics analyses using data for 229 patients from a Korean NSCLC cohort 462 previous studies. Histological examination reveals five molecular subtypes, one of which subtype with PI3K-Akt pathway upregulation, showing high...
Testis development, including early embryonic gonad formation and late postnatal spermatogenesis, is essential for the reproduction of higher metazoans to generate fertile gametes, called sperm. We have previously reported that polyubiquitin gene Ubb required fertility in both male female mice. In particular, Ubb-null mice showed an azoospermia phenotype due arrest spermatogenesis at pachytene stage. Here, we analyzed whole testis proteome day 20 define molecular mediators male-infertility...
Abstract Background Whole-genome doubling (WGD) is prevalent in cancer and drives tumor development chromosomal instability. Driver mutations mitotic cell cycle genes upregulation have been reported as the major molecular underpinnings of WGD tumors. However, underlying genomic signatures regulatory networks involved gene transcription kinase phosphorylation remain unclear. Here, we aimed to comprehensively decipher landscape Methods We performed a pan-cancer proteogenomic analysis compared...
Abstract As research into the complexities of cancer biology deepens, integration multi-omics analyses has emerged as a powerful approach to unravel complex molecular basis cancers. However, challenges related sample availability, including size, collection procedures, and storage duration, hinder broad application this methodology. Despite these limitations, there is growing interest in exploring potential archived samples expand scope research. Our study aims investigate impact duration on...