A5075671957- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Gestational Trophoblastic Disease Studies
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Congenital Anomalies and Fetal Surgery
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Prenatal Screening and Diagnostics
- Gastrointestinal disorders and treatments
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Microtubule and mitosis dynamics
- Teratomas and Epidermoid Cysts
- Polyomavirus and related diseases
Incheon St. Mary's Hospital
2017-2024
Catholic University of Korea
2018-2024
Asan Medical Center
2013-2021
Ulsan College
2013-2019
University of Ulsan
2013-2019
The Ohio State University
2019
The University of Texas Health Science Center at San Antonio
2019
The University of Texas Health Science Center at Houston
2019
Vancouver General Hospital
2019
UMass Memorial Health Care
2019
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) alternative lengthening of telomeres (ALT) to be promising prognostic biomarkers for non-functional pancreatic neuroendocrine tumours (NF-PanNETs). However, they not been comprehensively evaluated, especially among small NF-PanNETs (≤2.0 cm). Moreover, their status in (NETs) from other sites...
Purpose: Alternative lengthening of telomeres (ALT), a telomerase-independent telomere maintenance mechanism, is strongly associated with ATRX and DAXX alterations occurs frequently in pancreatic neuroendocrine tumors (PanNET).Experimental Design: In Korean cohort 269 surgically resected primary PanNETs 19 sporadic microadenomas, ALT status nuclear protein expression were assessed compared clinicopathologic factors.Results: PanNETs, or loss ATRX/DAXX was observed 20.8% 19.3%, respectively,...
Pancreatic cancer is among the deadliest malignancies; however, genetic events that lead to pancreatic carcinogenesis in adults remain unclear. In vivo models which these alterations occur adult animals may more accurately reflect features of human cancer. this study, we demonstrate inactivation Cdkn2b (p15ink4b) necessary for induction by oncogenic KRASG12D expression and Tp53 Cdkn2a mouse ductal cells (P60 or older). overexpression activated transforming growth factor-β signaling CDKN2B,...
Heterotopic pancreas (HP) can be detected by accompanying symptoms or incidentally during gastrointestinal (GI) tract tumor resection. We compared clinicopathologic features among 165 resected HPs (57 gastric [35%], 56 duodenal [34%], 30 omental [18%], and 22 jejunal [13%]). Symptomatic (79/135 GI wall HPs, 59%) were larger (P=0.05), more common in younger patients a location (both P<0.001), frequently associated with lymphoid cuffs (P=0.03) than found HPs. Gastric/jejunal symptomatic...
Objectives There is an increasing need for grading with small endoscopic ultrasound–guided fine needle aspiration biopsy (EUS-FNAB) specimens the proper diagnosis and therapy selection of patients unresectable pancreatic neuroendocrine tumors (PanNET). However, our understanding EUS-FNAB specimen limited compared surgically resected specimens. Methods We retrospectively determined Ki-67 labeling index (LI) 33 matched PanNETs digital image analyzer. Pairwise grades between PanNET were...
Purpose The most recent 2017 World Health Organization (WHO) classification of pancreatic neuroendocrine neoplasms (PanNENs) has refined the three-tiered 2010 scheme by separating grade 3 tumors (G3 PanNETs) from poorly differentiated carcinomas (PanNECs). However, differentiating between G3 PanNETs and PanNECs is difficult in clinical practice. Materials Methods Eighty-two surgically resected PanNENs were collected 16 institutions reclassified according to WHO based on histological features...
Pancreatic neuroendocrine tumors (PanNETs) are malignant of endocrine origin from the pancreas and comprise 1.3% to 2.8% all pancreatic neoplasms. 1The incidence prevalence PanNETs have increased over past decades according data Surveillance, Epidemiology, End Results (SEER) study. 2 Compared with ductal adenocarcinoma pancreas, generally considered indolent behaviors diverse clinical features ranging benign highly malignant. 3,4Therefore, predicting behavior is very difficult.A recent...
Background: Pancreatic neuroendocrine tumors (PanNETs) are the second most common pancreatic neoplasms and there is no well-elucidated biomarker to stratify their detection prognosis.Previous studies have reported that progesterone receptor (PR) expression status was associated with poorer survival in PanNET patients.Methods: To validate previous studies, PR protein assessed 21 microadenomas 277 PanNETs compared clinicopathologic factors including patient survival.Results: gradually...
// In Ja Park 1 , Soyeon An 5 Sang-Yeob Kim 3, 4 Hye Min Lim Seung-Mo Hong 2 Mi-Ju Yun Jae and Chang Sik Yu Department of Colon Rectal Surgery, University Ulsan College Medicine Asan Medical Center, Seoul, Korea Pathology, 3 Convergence Medicine, Institute for life sciences, Incheon St. Mary's Hospital, The Catholic Korea, Incheon, Correspondence to: Yu, email: csyu@amc.seoul.kr Kim, sykim3yk@amc.seoul.kr Keywords: rectal cancer, preoperative chemoradiotherapy, responsiveness, immune...
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a highly aggressive small round cell that mainly occurs in the bone or soft tissue of children young adults but extremely rare stomach. A 55-year-old man presented with melena and anemia. On endoscopy, an ulcerofungating mass was observed high body total gastrectomy performed. Histologically, consisted cells scanty cytoplasm inconspicuous nucleoli. They often formed perivascular pseudorosettes multinucleated giant were frequently...
Tumors from 25 patients with pancreatic cancer were used to establish two patient-derived xenograft (PDX) models: orthotopic PDX (PDOX) and heterotopic (subcutaneous) (PDHX). We compared gene expression by immunohistochemistry, single-nucleotide polymorphism (SNP), DNA methylation, metabolite levels. The 4 cases, of the total 13 in which simultaneous PDHX & PDOX models established, randomly selected. molecular-genetic characteristics patient's tumor well maintained models. SNP analysis...
Extrauterine epithelioid trophoblastic tumors constitute an extremely rare gestational disease. We report the case of extrauterine tumor that was incidentally detected in left lung. Squamous cell carcinoma suspected after microscopically examining specimen obtained upon preoperative needle biopsy. After surgery, confirmed by microscopic findings and immunohistochemical features.
Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from mid-axilla to medial groin. It histologically and immunohistochemically identical MFB of breast part spectrum lesions that includes lipoma cellular angiofibroma. Recently, we experienced two cases mammary-type involving male patients aged 30 58 years, respectively. The tumors were located in right scrotal sac axilla. Wide excisions performed. Microscopically, masses...
Pancreatic ductal adenocarcinomas are among the most malignant neoplasms and have very poor prognosis. Our understanding of various cancers has recently improved survival patients with cancer, except for pancreatic cancers. Establishment primary cancer cell lines will be useful molecular mechanisms this disease. Eighty-one surgically resected were collected. Six novel lines, AMCPAC01–06, established histogenetic characteristics compared their matched tissues. The clinicopathologic...
Highlights•TILs were related to T category and pancreatic/duodenal invasion in DBDCs.•sTILs consistently predicted OS even when tested with different cut-offs prognostically stratified RFS DBDCs.•Survival benefit of sTILHigh persisted regardless the stage DBDCs.AbstractBackgroundThe assessment tumor-infiltrating lymphocytes (TILs) has led development various immunotherapies beyond their predictive potential gastrointestinal malignancies. However, clinicopathologic prognostic values TILs have...