A5055146614- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Urologic and reproductive health conditions
- Ocular Oncology and Treatments
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- AI in cancer detection
- Head and Neck Cancer Studies
- Mast cells and histamine
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Kruppel-like factors research
- Prostate Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
Kyung Hee University
2025
University of Ulsan
2017-2024
Asan Medical Center
2017-2024
Ulsan College
2017-2024
Ewha Womans University
2023-2024
Armed Forces Capital Hospital
2019
Aims To assess the distinct histopathological characteristics and their clinical significance between non‐Hunner‐type Hunner‐type interstitial cystitis (IC)/bladder pain syndrome (BPS). Methods results We prospectively enrolled classified IC/BPS patients, on basis of cystoscopic findings, as having IC IC. Specimens obtained from posterior wall in cases during hydrodistension or Hunner/non‐Hunner lesions transurethral resection were evaluated. Stress urinary incontinence patients with...
Radical cystectomy with preoperative cisplatin-based neoadjuvant chemotherapy (NAC) is the standard care for muscle-invasive bladder cancers (MIBCs). However, complete response rate to this modality remains relatively low, and current clinicopathologic molecular classifications are inadequate predict NAC in patients MIBC. Here, we demonstrate that dysregulation of glutathione (GSH) pathway fundamental MIBC resistance. Comprehensive analysis multicohort transcriptomes reveals GSH metabolism...
Vascular endothelial growth factor tyrosine kinase inhibitors (TKIs) have been the standard of care for advanced and metastatic clear cell renal carcinoma (ccRCC). However, therapeutic effect TKI monotherapy remains unsatisfactory given high rates acquired resistance to therapy despite favorable initial tumor response.
This study presents a novel case of gastric carcinoma (GC) with diverse histological features and unique molecular alterations. A 62-year-old man hematemesis was diagnosed advanced GC hepatic metastasis. Despite palliative gastrectomy to control bleeding, the patient succumbed within 6 months. Histological examination revealed three distinct tumour components: Gastric adenosquamous (GASC), lymphoid stroma (GCLS) poorly differentiated adenocarcinoma (PDAD). Immunohistochemical staining,...
Objective The Paris System ( TPS ), which was recently introduced, emphasised the key features of malignant urine cytology: a high nuclear to cytoplasmic ratio, hyperchromasia, irregular membranes and coarse chromatin. Although other diagnostic have been described, significance such their application not fully defined for urinary tract washing specimens. Methods A total 142 cases specimens with corresponding surgical pathology samples were examined 13 previously described features....
Basaloid squamous cell carcinoma (BSCC) is a rare variant of with distinct pathologic characteristics. The histogenesis BSCC not fully understood, and the cancer has been suggested to originate from totipotent primitive in basal layer surface epithelium or proximal duct secretory glands.Twenty-six cases head neck Asan Medical Center, Seoul, Korea, reported during 14-year-period were subclassified into basal, ductal, mixed subtypes according expression (cytokeratin [CK] 5/6, p63) ductal...
Background: Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined.Methods: To define its immunoprofile, clinicopathological features, including biochemical recurrence (BCR), 61 cases DAC were analyzed.Immunohistochemistry was performed on tissue microarray constructs to assess expression cancer-related mammalian target rapamycin (mTOR) signaling-related proteins.Results: During median follow-up...
Purpose Tyrosine kinase inhibitors (TKI) targeting vascular endothelial growth factor receptor (VEGFR) signaling pathways have been used for metastatic clear cell renal carcinoma (mCCRCC), but resistance to the drug develops in most patients. We aimed explore underlying mechanism of TKI with regard programmed death-ligand 1 (PD-L1) and investigate pathway associated resistant mechanism.Materials Methods To determine resistance, 10 mCCRCC patients from whom tumor tissues were harvested at...
This study aimed investigate the effect of level invasion into fibromuscular band (FMB) prostate on positive surgical margin (PSM) and biochemical recurrence (BCR) after radical prostatectomy (RP) in patients with organ-confined (pT2) cancer. The clinical pathological data 461 consecutive pT2 cancer were evaluated regarding FMB. relationship between levels FMB PSM / BCR was assessed. rate at an 2 18.8%, which significantly greater than rates 0 (5.4%) 1 (7.8%). (p = 0.007) percentage tumor...
Prognostic significance of macroscopic appearance clear cell renal carcinoma (ccRCC) has not yet been studied. This study aimed to define the prognostic and propose a model for post‐operative metastasis in ccRCC. A total 1,025 patients with ccRCC were analyzed development dataset. separate cohort 399 such was used as an external validation Macroscopic appearances initially divided into four groups, but later two groups: simple nodular group (700 cases, 68.3%) irregular outline (325 32.7%)....
Background: Bladder cancer is characterized by frequent mutations, which provide potential therapeutic targets for most patients. The effectiveness of emerging personalized therapies depends on an accurate molecular diagnosis, the estimation neoplastic cell percentage (NCP) a crucial initial step. However, established method determining NCP, manual counting pathologist, time-consuming and not easily executable. Methods: To address this, artificial intelligence (AI) models were developed to...
Although SCNEC is based on its characteristic histology, immunohistochemistry (IHC) commonly employed to confirm neuroendocrine differentiation (NED). The challenge here that may yield negative results for traditional markers. To establish an IHC panel NED, 17 neuronal, basal, and luminal markers were examined a tissue microarray construct generated from 47 cases of 34 patients with as discovery cohort. A decision tree algorithm was analyze the extent intensity immunoreactivity develop...