A5011736488- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Pluripotent Stem Cells Research
- Urinary Bladder and Prostate Research
- Mesenchymal stem cell research
- Urological Disorders and Treatments
- Renal and related cancers
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Genomics, phytochemicals, and oxidative stress
- Political Theology and Sovereignty
- Educational Robotics and Engineering
- Video Coding and Compression Technologies
- Legal principles and applications
- Vitamin C and Antioxidants Research
- Microbial metabolism and enzyme function
- Molecular Junctions and Nanostructures
- Education and Learning Interventions
- Histone Deacetylase Inhibitors Research
- Emotions and Moral Behavior
- Property Rights and Legal Doctrine
- Parallel Computing and Optimization Techniques
- Seventeenth-Century Political and Philosophical Thought
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
University of Ulsan
2015-2025
Asan Medical Center
2015-2025
Ulsan College
2015-2025
Cell Biotech (South Korea)
2020
National Academy of Agricultural Science
2009
Mesenchymal stem cells (MSCs) are of particular interest for the treatment immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness immunomodulatory functions treating allogeneic conflicts. Compared naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant passage-dependent senescence mediated via monocyte chemoattractant protein-1 p53/p21 cascade secreted...
Interstitial cystitis (IC) is a syndrome characterized by urinary urgency, frequency, pelvic pain, and nocturia in the absence of bacterial infection or identifiable pathology. IC devastating disease that certainly decreases quality life. However, causes remain unknown no effective treatments cures have been developed. This study evaluated therapeutic potency using human umbilical cord-blood-derived mesenchymal stem cells (UCB-MSCs) to treat rat model investigate its responsible molecular...
Aims To assess the distinct histopathological characteristics and their clinical significance between non‐Hunner‐type Hunner‐type interstitial cystitis (IC)/bladder pain syndrome (BPS). Methods results We prospectively enrolled classified IC/BPS patients, on basis of cystoscopic findings, as having IC IC. Specimens obtained from posterior wall in cases during hydrodistension or Hunner/non‐Hunner lesions transurethral resection were evaluated. Stress urinary incontinence patients with...
Molecular programs involved in embryogenesis are frequently upregulated oncogenic dedifferentiation and metastasis. However, their precise roles regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orchestrated pluripotency cell-cycling embryonic stem cells (ESCs) was aberrantly activated aggressive bladder cancers (BCs). In murine ESCs, the protein interactome targets Tfcp2l1 indicated its involvement...
Abstract Abuse of the hallucinogenic drug ketamine promotes development lower urinary tract symptoms that resemble interstitial cystitis. The pathophysiology ketamine-induced cystitis (KC) is largely unknown and effective therapies are lacking. Here, using a KC rat model, we show therapeutic effects human umbilical cord-blood (UCB)-derived mesenchymal stem cells (MSCs). Daily injection to Sprague-Dawley rats for 2-weeks resulted in defective bladder function, indicated by irregular voiding...
Real-time monitoring of GSH dynamics demonstrates the functional roles CREB1-NRF2 pathway in MSC therapeutic potency.
Stem cell (SC) therapy has become a potential treatment modality for pulmonary artery hypertension (PAH), but the efficacy of human SC and priming effects have not yet been established. The mobilization homing hematopoietic stem cells (HSCs) are modulated by factors that include bioactive lipid, sphingosine-1-phosphate (S1P), which stimulates CXCR4 receptor kinase signaling. Here, we show mesenchymal (MSCs) with S1P enhances their therapeutic in PAH. Human MSCs, similar to HSCs, showed...
Abstract Aberrant activation of embryogenesis-related molecular programs in urothelial bladder cancer (BC) is associated with stemness features related to oncogenic dedifferentiation and tumor metastasis. Recently, we reported that overexpression transcription factor CP2-like protein-1 (TFCP2L1) its phosphorylation at Thr177 by cyclin-dependent kinase-1 (CDK1) play key roles regulating carcinogenesis. However, the clinical relevance therapeutic potential this novel CDK1-TFCP2L1 network...
Abstract Glutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem cells. A detailed understanding molecular network mediating GSH dynamics is still lacking. Here, we show that activating transcription factor-2 (ATF2), a cAMP-response element binding protein (CREB), plays crucial role maintaining level activity human mesenchymal cells (MSCs) by crosstalking with nuclear factor erythroid-2 like-2 (NRF2),...
Radical cystectomy with preoperative cisplatin-based neoadjuvant chemotherapy (NAC) is the standard care for muscle-invasive bladder cancers (MIBCs). However, complete response rate to this modality remains relatively low, and current clinicopathologic molecular classifications are inadequate predict NAC in patients MIBC. Here, we demonstrate that dysregulation of glutathione (GSH) pathway fundamental MIBC resistance. Comprehensive analysis multicohort transcriptomes reveals GSH metabolism...
Aims: The naive or primitive states of stem cells (SCs) residing in specific niches are unstable and difficult to preserve vitro. Vitamin C (VitC), addition suppressing oxygen radicals, exerts pleiotropic effects the core functions SCs. However, this compound is labile readily oxidized, resulting cellular toxicity preventing its reliable application context. We found that a VitC derivative, ascorbic acid 2-glucoside (AA2G), stably maintains pluripotency murine embryonic SCs (mESCs)...
The AllergenPro database has developed a web-based system that will provide information about allergen in microbes, animals and plants. three major parts functions:(i) list; (ii) search; (iii) allergenicity prediction. contains 2,434 allergens related readily available the such as on rice microbes (712 records), (617 records) plants (1,105 records). Furthermore, this provides bioinformatics tools for Users can search specific by various methods run prediction using different methods.The is...
세계적으로 아날로그 방송에서 디지털 방송으로의 전환이 마무리되고 있는 가운데, 앞으로 다가올 UHDTV 등 실감의 대용량 방송 및 통신 융합 환경에 대비하기 위한 새로운 차기 표준에 관한 연구의 필요성이 날로 높아져 가고 있다. 특히, 저해상도 서비스에 머물러 있던 모바일 방송에서는 기존 HD급의 서비스 제공이 가능한 실감방송으로 진화하기 때문에 고정/이동 서비스가 동시에 고효율 전송 원천 기술 개발이 이루어질 필요가 이에 최근 지상파 단일 채널을 통해 4K UHD (거치형) & HD (모바일) 서비스를 제공하는 융합방송 시스템 개발에 대해서 연구가 진행되고 본 논문에서는 최신의 기법 영상 압축 기술에 소개하고, 제공하기 모델 요구 사항들에 분석한다. 이 후 기술을 적용하였을 때, 6MHz 8MHz 대역폭에서 융합방송을 전송하기 위해 필요한 최적의 파라메터를 도출하고 이를 이용해 AWGN TU-6 채널에서의 수신 성능을 검증하였다. 대역폭에서의 원활한 데이터의 수신이 140...