A5054104985- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Congenital Anomalies and Fetal Surgery
- Genomic variations and chromosomal abnormalities
- Cytomegalovirus and herpesvirus research
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Cleft Lip and Palate Research
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Medical and Health Sciences Research
- Autopsy Techniques and Outcomes
- Herpesvirus Infections and Treatments
- Renal and related cancers
- Urological Disorders and Treatments
- Cancer Genomics and Diagnostics
University of Tübingen
2016-2025
University Children's Hospital Tübingen
2012-2025
Universitätsklinikum Tübingen
2015-2025
Universitäts Frauenklinik
2011-2024
Institut für Frauengesundheit
2020-2021
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
St Martins Hospital
2017
Barco (Belgium)
2014
King's College Hospital
2006-2010
Abstract Objectives To use multiple regression analysis to define the contribution of maternal variables that influence measured concentration free beta‐human chorionic gonadotropin (β‐hCG) and pregnancy‐associated plasma protein‐A (PAPP‐A), interaction between these covariates, in first‐trimester biochemical screening for trisomy 21. Methods This was a multicenter study prospective 21 by combination fetal nuchal translucency thickness, serum β‐hCG PAPP‐A at 11 + 0 13 6 weeks gestation. In...
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice high-quality teaching research related to diagnostic imaging women's healthcare. ISUOG Clinical Standards Committee (CSC) has remit develop Practice Guidelines Consensus Statements as educational recommendations provide healthcare practitioners with consensus-based approach, from experts, for imaging. They are intended reflect what considered by be...
Abstract Objective Fetal nuchal translucency (NT) thickness increases with crown–rump length (CRL). In screening for chromosomal defects patient‐specific risks are derived by multiplying the a priori maternal age‐related risk likelihood ratio, determined from deviation of measured NT expected median. To quantify this is either subtracted (delta NT) or divided median (multiple method, MoM). This study examines validity these methods. Methods was prospectively at 11 + 0 to 13 6 weeks in...
Abstract Objectives To investigate the performance of first‐trimester screening for aneuploidies by including assessment ductus venosus flow in combined test maternal age, fetal nuchal translucency thickness, heart rate, and serum free β‐human chorionic gonadotropin pregnancy‐associated plasma protein‐A. Methods Screening was performed singleton pregnancies, 19 614 with euploid fetuses, 122 trisomy 21, 36 18, 20 13 eight Turner syndrome. In all cases a‐wave assessed. We examined two...
Abstract Background Tumour size in breast cancer influences therapeutic decisions. The purpose of this study was to evaluate sizing primary using mammography, sonography and magnetic resonance imaging (MRI) thereby establish which method most accurately corresponds with the histological result. Methods Data from 121 patients were analysed a retrospective study. results divided into groups “ductal carcinoma situ (DCIS)”, invasive ductal (IDC) + “invasive (IDC)”, lobular (ILC)” “other tumours”...
Abstract Objective To examine in monochorionic pregnancies the possible value of intertwin discordance nuchal translucency (NT) thickness prediction early fetal death or severe twin–twin transfusion syndrome (TTTS). Methods In 512 twin NT was measured at 11 to 13 + 6 weeks' gestation and regression analysis used determine significance association between subsequent development TTTS requiring endoscopic laser surgery. Results 412 (80.5%) there a normal outcome, 58 (11.3%) surgery 18–24 weeks,...
Abstract Objective To investigate the performance of first‐trimester screening for aneuploidies by including assessment fetal nasal bone in combined test maternal age, nuchal translucency (NT) thickness, heart rate (FHR) and serum free β‐human chorionic gonadotropin (β‐hCG) pregnancy‐associated plasma protein‐A (PAPP‐A). Methods Screening was performed singleton pregnancies, 19 614 with euploid fetuses, 122 trisomy 21, 36 18, 20 13 eight Turner syndrome. In all cases assessed classified as...
In Brief OBJECTIVE: To examine the prevalence and distribution of all chromosomal defects in fetuses with increased nuchal translucency thickness. METHODS: Assessment risk for trisomy 21 was carried out by a combination maternal age fetal thickness at 11–13 + 6 weeks. A search database made to identify, first, singleton pregnancies which karyotyping and, second, cases where equal or above 95th centile crown-rump length. The were determined each category: between length 3.4 mm, 3.5–4.4...
<i>Introduction:</i> The aim of this retrospective clinical study was to compare the accuracy 36 commonly used weight estimation formulae in macrosomic fetuses. <i>Material and Methods:</i> Ultrasound fetal (FW) carried out within 7 days up delivery 350 singleton fetuses with a birth (BW) ≧4,000 g. different for FW compared by, firstly, mean percentage (MPE) absolute error (MAPE), secondly, by frequency distribution differences between estimated BW, thirdly comparing...
The widespread use of fetal cell-free DNA (cfDNA)-based techniques to screen for trisomy 21 and other aneuploidies has expanded greatly the range prenatal tests available over last few years. cfDNA are being incorporated rapidly into care, thus changing traditional approach screening diagnosis. However, although highly efficient, their role performance must be considered alongside combined with modalities. ultrasound, in particular, needs reaffirmed as testing becomes more widely available....
We describe a case series of six fetuses with open spina bifida (OSB) from four different prenatal units, where the anomaly was detected at routine 11-13-week ultrasound examination. Crown-rump length ranged 49 to 78 mm. All cases were first suspected during nuchal translucency thickness measurement in mid-sagittal plane face. OSB lumbosacral five and cervical one. The intracranial (IT) obliterated two cases, but some fluid found other cases. However, all typical landmarks normal posterior...
First-trimester screening between 11 + 0 and 13 6 weeks with qualified prenatal counseling, detailed ultrasound, biochemical markers maternal factors has become the basis for decisions about further examinations. It detects numerous structural genetic anomalies. The inclusion of uterine artery Doppler PlGF screens preeclampsia fetal growth restriction. Low-dose aspirin significantly reduces prevalence severe preterm eclampsia. Cut-off values define groups high, intermediate low probability....
Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), congenital disorder characterized by uterovaginal aplasia, but functional ovaries. Based on our four successful living-donor transplantations and two resulting births, this analysis presents parameters relevant standardizing recipient/donor selection, UTx surgery, postoperative treatment, their implementation in routine settings. We descriptively analyzed...
ABSTRACT Objective To examine the efficacy of hyperimmunoglobulin (HIG) treatment in women with a recent primary cytomegalovirus (CMV) infection up to 14 weeks' gestation. Methods This is an ongoing observational study conducted at prenatal medicine departments University Hospitals Tübingen, Bonn, Cologne and Erlangen, Germany, as well Laboratory Prof. Gisela Enders Colleagues Stuttgart, Germany Institute for Medical Virology Germany. Enrolment criteria were presence confirmed CMV first...
Abstract The management of congenital lung malformations (CLM) remains controversial. aim this study was to analyze the timing, approach, and outcomes surgical treatment in children with CLM. A cohort conducted comparing CLM who underwent thoracoscopic resection open via thoracotomy. All were treated according an institutionalized multidisciplinary coordinated algorithm. Between 2002 2019, 68 treated. Thoracoscopic (n=44) resulted a statistically significant longer operative time (mean 169...
In Brief OBJECTIVE: To estimate the incidence of septations in fetuses with increased nuchal translucency (NT) thickness, and to investigate relationship between length thickness whether or provide useful information concerning fetal karyotype addition that provided by NT alone. METHODS: We examined 386 equal above 95th percentile for crown-rump (CRL). A transverse suboccipitobregmatic section head was taken determine sonolucency septated, a midsagittal longitudinal used measure CRL,...
Abstract Objective To determine the number of scans necessary for training sonographers to examine accurately ductus venosus at 11 + 0 13 6 weeks' gestation. Methods Ten with prior extensive experience in measurement nuchal translucency thickness were given practical accurate assessment venosus. They then asked during routine scan. Each scan was assessed by an experienced sono‐ grapher and classified as being successful or unsuccessful (failure obtain a waveform, poor quality image...
Abstract Objective To examine the distribution of first‐trimester biochemical markers aneuploidy in twin pregnancies, and to assess whether there are differences distributions between monochorionic dichorionic twins. Methods Maternal serum‐free β‐hCG PAPP‐A were measured 11 + 0 13 6 weeks as part a routine screening program conjunction with fetal nuchal translucency (NT) performed at two sites. Data from pregnancies extracted databases along information on chorionicty. The individual marker...
The image on the cover of this month's Journal shows a 7-week embryo obtained using Voluson E8 (GE Medical Systems, Zipf, Austria) ultrasound machine equipped with new surface render mode, ‘HDlive’ (Figure 1). Figure 2 another case at 10 weeks, same technique. HDlive system uses an adjustable light source, giving operator opportunity to create lighting and shadowing effects thereby increasing depth perception. In both images it is clear see that capacity adjust lighting, combined use...