A5072959229- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Cell death mechanisms and regulation
- Congenital Diaphragmatic Hernia Studies
- Abdominal Trauma and Injuries
- Microtubule and mitosis dynamics
- Tracheal and airway disorders
- Orthopedic Infections and Treatments
- Esophageal and GI Pathology
- Hip and Femur Fractures
- Liver physiology and pathology
- Pelvic and Acetabular Injuries
- Bone Tumor Diagnosis and Treatments
- Trauma and Emergency Care Studies
- Hip disorders and treatments
- Shoulder and Clavicle Injuries
- Trauma Management and Diagnosis
- RNA Interference and Gene Delivery
- Pleural and Pulmonary Diseases
- Musculoskeletal Disorders and Rehabilitation
- Cancer-related Molecular Pathways
- Urological Disorders and Treatments
- Sarcoma Diagnosis and Treatment
University Children's Hospital Tübingen
2013-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2011-2025
Universitätsklinikum Tübingen
2011-2025
Olgahospital
2023
University of Tübingen
2022
TH Bingen University of Applied Sciences
2021
Klinikum rechts der Isar
2021
Universitätskinderklinik
2011-2014
Boston Children's Hospital
2011-2012
St. Hedwig-Krankenhaus
2005
Traumatic posterior dislocation of the elbow is often associated with significant morbidity and incomplete recovery. The aim this study was to retrospectively analyse outcome 33 children (median age 10.8 years). Patients underwent reduction assessment stability under general anaesthesia. Pure dislocations (n=10) were immobilized, whereas unstable fractures (n=23) stabilized. Refixation ligaments performed if not achieved by fracture stabilization alone. Immobilization continued for 26 (pure...
Abstract Background Treatment of unstable forearm fractures in the metaphyseal-diaphyseal junction (MDJ) zone is still a matter debate. Major drawbacks all types fixations include either invasiveness, technical impracticality, or lack acceptance by patients. This study reports results after antegrade ESIN (a-ESIN) compared to transepiphyseal intramedullary K-wire (TIK) for MDJ fractures. Methods The was defined as square over joints both bones subtracted with metaphysis radius alone. data 40...
Abstract The management of congenital lung malformations (CLM) remains controversial. aim this study was to analyze the timing, approach, and outcomes surgical treatment in children with CLM. A cohort conducted comparing CLM who underwent thoracoscopic resection open via thoracotomy. All were treated according an institutionalized multidisciplinary coordinated algorithm. Between 2002 2019, 68 treated. Thoracoscopic (n=44) resulted a statistically significant longer operative time (mean 169...
Background: The classification of fractures is necessary to ensure a reliable means communication for clinical interaction, research, and education. Distal humeral coronal plane shear (CSF) are very rare in the growing-age population, despite that multiple schemes exist. Objective: aim this study was assess inter- intra-rater reliability 4 most commonly used CSF classifications their role guiding treatment decisions everyday practice. Materials methods: 51 patients with were retrospectively...
In unstable metaphyseal and diaphyseal forearm fractures the treatment of choice is percutaneous Kirschner wire (K-wire) fixation or elastic stable intramedullary nailing (ESIN), respectively. The optimal for diametaphyseal transition zone still a matter debate.The was defined as square over "physis distal radius ulna" minus alone". Transepiphyseal K-wire performed in affecting this transitional area. operative, postoperative functional outcomes were assessed compared to previously treated...
An increased expression of anti-apoptotic proteins is regularly found in malignant cells, contributing to their clonal expansion by conferring an improved survival ability. In Hepatoblastoma (HB) apoptosis regulation contributes resistance and therapy failure, therefore we modulated sensitivity HB cells for cytotoxic activity commonly used drugs.Apoptosis-related were quantified (HuH6 HepT1) using protein assays. Interaction ABT-737, a small-molecule inhibitor Bcl-2, Bcl-xL, Bcl-W with drugs...
Elastic stable intramedullary nailing (ESIN) is the first-choice surgical technique for stabilizing various pediatric diaphyseal and selected metaphyseal fractures of long bones. This has increasingly been applied in small Here, we report experiences with ESIN displaced metacarpals children.Retrospective data analysis metacarpal children stabilized by three trauma centers between 2003 2009. Indication intervention was total displacement or axial deviation >10 degrees frontal plane and/or >30...
Total colonic aganglionosis (TCA) is a rare variant of Hirschsprung’s disease occurring in 3–10% the cases. Only few studies reported long-term clinical and metabolic outcomes patients with TCA. The aim this study was to evaluate functional children undergoing surgical treatment for A 15-year retrospective performed. Blood chemistry tests stool analysis performed at last follow-up visit were recorded. Height weight development assessed using corresponding percentiles age. Faecal continence...
The primary goal of current chemotherapy in hepatoblastoma (HB) is reduction tumour volume and vitality to enable complete surgical resection reduce risk recurrence or metastatic disease. Drug resistance remains a major challenge for HB treatment. In some malignancies inhibition anti-apoptotic pathways using small BH3 mimetic molecules like ABT-737 shows synergistic effects combination with cystotoxic agents vitro. Now we analysed toxicology this approach cells xenografts.Viability was...
Pediatric radial neck and head fractures are rare, accounting for only 1% of all in children. The aim this study is to describe the management results respective fracture types different injury characteristics.This performs a retrospective data analysis 100 consecutive patients with proximal radius treated single high-volume pediatric trauma center.One hundred [mean age 7.5 years (1-15)] were documented between 3/2011 12/2019. gender distribution was 62 girls 38 boys. Twenty-seven had...
In children with benign bone defects, various treatment options are recommended. Whether these defects should be curetted, osteosynthetically stabilized and/or filled allogenic or synthetic material is still a matter of controversy.The reported study presents preliminary results five lesions the lower extremity. Curettage and filling defect commercially available silicate-substituted calcium phosphate (SiCaP) (Actifuse® by ApaTech Ltd., Elstree, United Kingdom) was performed. Patients were...
ESIN (elastic stable intramedullary nailing) is considered the gold standard for various pediatric fractures. The aim of this study was to analyze incidence and type complications during or after TEN (titanium elastic nail) removal.A retrospective data analysis performed. Metal removal associated preoperative extraosseous length/outlet angle TENs as possible causes were assessed.The complication rate in 384 removals 3.1% (n = 12). One major (rupture M. extensor pollicis brevis) documented....