A5020055917- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Prenatal Screening and Diagnostics
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Dermatological and COVID-19 studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Syphilis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Fire effects on ecosystems
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- HIV Research and Treatment
- Toxoplasma gondii Research Studies
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Tumors and Oncological Cases
MVZ Labor Ravensburg
2013-2024
Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer
2015-2023
Rosenberger (Germany)
2009-2021
Institute of Virology of the Slovak Academy of Sciences
2012-2020
Charité - Universitätsmedizin Berlin
2012
Walter de Gruyter (Germany)
2012
Friedrich-Loeffler-Institut
2012
Universität der Bundeswehr München
2012
Institut für Mikrobiologie der Bundeswehr
2012
Slovak Academy of Sciences
2012
Abstract Objective To determine more precisely the incidence of fetal complications following maternal parvovirus B19 infection at various gestational ages. Methods An observational prospective study 1018 pregnant women whose acute was serologically confirmed in our laboratory. Results The observed rate death throughout pregnancy 6.3% (64/1018) (95% confidence interval [CI]: 4.9, 8.0). for those infected within first 20 weeks gestation (WG) 64/579 (11.0%). Fetal only when occurred before...
To examine the efficacy of biweekly hyperimmunoglobulin (HIG) administration to prevent maternal-fetal transmission cytomegalovirus (CMV) in women with primary first-trimester CMV infection.This was a prospective observational study confirmed infection first trimester who had HIG at or before 14 weeks' gestation. All treatment until 20 gestation dose 200 IU/kg maternal body weight. Each subject underwent amniocentesis least 6 weeks after presentation about weeks. Primary outcome time...
ABSTRACT Objective To examine the efficacy of hyperimmunoglobulin (HIG) treatment in women with a recent primary cytomegalovirus (CMV) infection up to 14 weeks' gestation. Methods This is an ongoing observational study conducted at prenatal medicine departments University Hospitals Tübingen, Bonn, Cologne and Erlangen, Germany, as well Laboratory Prof. Gisela Enders Colleagues Stuttgart, Germany Institute for Medical Virology Germany. Enrolment criteria were presence confirmed CMV first...
Human parvovirus B19 has been linked to a variety of cardiac diseases, as well erythema infectiosum, acute arthropathy, and fetal hydrops. A causal association between viral infection disease was frequently postulated following the detection DNA by PCR in endomyocardial biopsy specimens. Since lifelong persistence bone marrow, skin, synovia, tonsils, liver previously reported, aim our study investigate possibility asymptomatic heart tissue. Myocardial autopsy postmortem blood samples were...
Abstract Aims: The aim of this study was to investigate the current prenatal “off-label use” cytomegalovirus hyperimmunoglobulin (CMV-HIG) in prevention and treatment congenital CMV (cCMV) infection, including long-term outcome children. Methods: This retrospective observational comprised mothers their children, born between January 1, 2006, October 30, 2010. Prenatal CMV-HIG administered after diagnosis primary infection mother. Clinical virological data were collected from maternal...
The objective of this study is to investigate the diagnostic value invasive prenatal diagnosis (PD) congenital cytomegalovirus (CMV) infection from amniotic fluid (AF) and fetal blood (FB).A retrospective was conducted on 115 pregnancies with CMV primary infection. A total 111 AF 106 FB samples were investigated for various virological non-virological markers. Detailed ultrasound examinations performed at time PD.Overall sensitivity PCR in (75.6%; 95%CI 60-87) (72.7%; 57-85) comparable. In...
To investigate 2,017 cases of hantavirus disease in Germany, we compared 38 new patient-derived Puumala virus RNA sequences identified 2010 with bank vole-derived small segment sequences. The epidemic process was driven by outbreaks 6 clades comprising strains human and vole origin. Each clade corresponded to a different outbreak region.
Seasonal RSV infections occur every year and affect particularly children under six months of age. Passive immunoprophylaxis with monoclonal antibody Palivizumab is recommended in the period high risk infection. This study aims to define for southern part Germany (Stuttgart area).Epidemiological analysis situation from 1996 2004 comparison results literature was made. The respiratory tract specimens were sent detection mainly by paediatric clinics. Detection carried out real-time RT-PCR or...
SUMMARY This investigation was undertaken to provide detailed information on the epidemiology of human parvovirus B19 (B19) infection during pregnancy and childhood in western part Germany. Between 1997 2004, 40 517 sera from pregnant women aged 17–45 years 6060 children young adults were tested for IgG IgM our laboratory. In women, both history a ‘specific’ (OR 7·7, 95% CI 5·2–11·4) ‘non-specific’ rash 3·3, 1·5–7·1) predictive positivity. The prevalence 69·2% (4097/5924) subgroup...
Background. In the diagnosis of parvovirus B19 infection, detection virus-specific IgG in absence IgM is considered to indicate past immunity.
Abstract From 2000 to 2005, a total of 1,096 enterovirus infections were diagnosed either by isolation virus from cell culture or RT‐PCR (5′non‐coding region (NCR)). Typing viruses (n = 674) was carried out immunofluorescence with monoclonal antibodies, neutralization test molecular methods. Seasons high activity characterized prevalence echovirus 30 (62.2% in 2000, 25.5% 2001) and 13 (34.5% 2001). In contrast, the 2003 season, which had very low activity, these types rare. During this...
Human enterovirus 71 (EV-71) is a cause of seasonal epidemics hand, foot and mouth disease, less common but severe neurological manifestations. Uncertainty persists regarding the circulation virus populations in several geographical areas timescale their dissemination. We determined EV-71 sequences at loci 1D (VP1 capsid protein) 3CD (non-structural proteins) 86 strains recovered Austria, France Germany performed an evolutionary genetic study extant populations. Phylogenetic analyses...
A convenient rapid culture assay (RCA) for the detection of enteroviruses was evaluated against RT-PCR using 576 stool and 102 cerebrospinal fluid (CSF) samples. One hundred ninety samples were also tested by conventional cell (CCC). The RCA used immunoperoxidase staining plates with a blend monoclonal antibodies (mAbs) enterovirus VP1 on second sixth days after inoculation. This composed 5D8/1 (Dako) four ‘in-house’ mAbs. CCC performed fluorescence Enterovirus Screening Set (Chemicon...
Antigen-specific antibodies are well characterized after vaccination with pandemic H1N1 or seasonal influenza vaccines. However, knowledge on cellular immunity toward and infection cross-reactivities antigens is limited. Nineteen individuals were vaccinated the vaccine. Among those, ten had been prevaccinated against influenza. CD4(+) T cells specific for vaccine, monitored using flow cytometry ELISA/neutralization assays, respectively. In addition, seven patients acute analyzed. Pandemic...
What's already known about this topic? Current guidelines recommend performing amniocentesis for prenatal diagnosis of CMV infection not before 21 weeks' gestation and at least 6 weeks after maternal infection. What does study add? Our data suggest that can be done without significant loss sensitivity. This has to confirmed in a controlled study. © 2017 John Wiley & Sons, Ltd.