A5056940578- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Estrogen and related hormone effects
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Gynecological conditions and treatments
- AI in cancer detection
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Genetic Syndromes and Imprinting
- Lung Cancer Treatments and Mutations
- Nutrition, Genetics, and Disease
- Sarcoma Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
University of Tübingen
2017-2024
Institut für Frauengesundheit
2016-2024
Universitätsklinikum Tübingen
2014-2024
University Children's Hospital Tübingen
2020-2023
Universitäts Frauenklinik
2014-2020
Olgahospital
2008-2014
University of Applied Sciences Landshut
2008-2009
ACTA (United States)
2009
Weatherford College
2009
Ludwig-Maximilians-Universität München
2009
Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), congenital disorder characterized by uterovaginal aplasia, but functional ovaries. Based on our four successful living-donor transplantations and two resulting births, this analysis presents parameters relevant standardizing recipient/donor selection, UTx surgery, postoperative treatment, their implementation in routine settings. We descriptively analyzed...
Abstract Background HPV-related cervical cancer (CC) is the fourth most frequent in women worldwide. Cell-free tumour DNA a potent biomarker to detect treatment response, residual disease, and relapse. We investigated potential use of cell-free circulating HPV-DNA (cfHPV-DNA) plasma patients with CC. Methods cfHPV-DNA levels were measured using highly sensitive next-generation sequencing-based approach targeting panel 13 high-risk HPV types. Results Sequencing was performed 69 blood samples...
The aim of the study was to evaluate efficacy high intensity focused ultrasound (HIFU) in treatment symptomatic breast fibroadenomas (FA) after 6 and 12 months.Between December 2013 November 2014, 27 patients with histologically confirmed FA received one application HIFU under local anesthesia (NCT02011919). Follow-up visits occurred months measuring volume clinical symptoms. A reduction more than 65% defined as success. Core needle biopsy (CNB) offered if indistinct residuals were visible...
Abemaciclib significantly improves invasive disease-free survival when combined with endocrine therapy in clinical high-risk patients HR+/Her2- early breast cancer (eBC). The objective of the following study was to model how many eBC would be available for adjuvant treatment abemaciclib a real-world setting. Patients that underwent complete surgical between January 2018 and December 2020 large single-center university hospital Germany were eligible. Descriptive statistics used describe...
Abstract Purpose Breast-conserving therapy is associated with a risk of tumor-involved margins. For intraoperative orientation, non- palpable or indistinctly lesions are wire-marked prior to surgery. Ultrasound-guided surgery has the potential reduce number In MAC 001 trial we evaluated ultrasound-guided breast-conserving compared wire-guided regard free tumor margins, duration and resection volume. Materials Methods this randomized, prospective, single-center controlled trial, patients...
Preclinical data suggest that neoadjuvant chemotherapy (NAT) may promote micrometastatic spread. We aimed to compare the detection rate and prognostic relevance of disseminated tumor cells (DTCs) from bone marrow (BM) patients with early-stage breast cancer (EBC) after NAT therapy-naive EBC patients. DTCs were identified BM samples, collected during primary surgery. Patients who received compared In total, 809 analyzed. After NAT, 45.4% DTC-positive as 19.9% in adjuvant group (p < 0.001)....
Background: The aim of this study was to evaluate the impact pathological tumor-free margin distance on survival in SCC patients treated with surgery alone. Methods: This retrospective included 128 node-negative disease that received no adjuvant treatment. Disease-free and overall were analyzed according distance. Results: subclassified into three resection category groups: “1 3 mm” (n = 42), “>3 8 47) or “>8 39). Thirty-nine (30.5%) developed recurrent disease. Median follow-up for...
Preoperative risk stratification of newly diagnosed endometrial carcinoma (EC) patients has been hindered by only moderate prediction performance for many years. Recently ENDORISK, a Bayesian network model, showed high predictive performance. It was the aim this study to validate ENDORISK applying model population-based case series EC patients.ENDORISK applied retrospective cohort women surgically treated from 2003 2013. Prediction accuracy LNM as well 5-year DSS investigated. The model's...
To highlight aspects of malignant ovarian sex cord stromal tumors, effects treatment, and developments over the past 28 years.Population-based cohort study.Gynecological departments within catchment-area Munich Cancer Registry associated with project group 'Malignant Ovarian Tumors' Center.One hundred forty-five women an invasive single tumor diagnosed between 1978 2005.Overall survival was estimated Kaplan-Meier method, relative computed by ratio observed to expected rate. The impact age,...
Abstract: The properties of the catecholamine‐storing organelles from transplantable rat phaeochromocytoma and adrenal glands were compared by density gradient centrifugation. It was shown that tumour granules are more heterogeneous less dense than granules. Both granule preparations can take up catecholamines nucleotides a process driven an electrochemical proton gradient. Dopamine β‐hydroxylase glycoprotein III analysed immunological techniques. Glycoprotein to be specific component...
Abstract Purpose Ultrasound-guided core needle biopsy (CNB) is considered the standard assessment to diagnose sonographically visible suspicious breast mass lesions. Based on nonrandomized trials, current German guidelines recommend at least three cylinders with ≤ 14-gauge biopsy. However, no recommendation made as how many specimens are needed a smaller size, such 16-gauge, or if coaxial guidance improves diagnostic accuracy and quality. Therefore, in prospective monocentric unblinded...
Abstract Purpose Postoperative seromas are a problem in the surgical treatment of breast cancer. The aim study was to evaluate whether lysine-urethane-based tissue adhesive TissuGlu ® without drainage is equal/ non-inferior standard mastecomy with drainage. Methods designed as prospective, randomized, multicentre non-inferiority comparing use wound care drain insertion ablative procedures. number clinical interventions, quality life and complications were followed-up for 90 days both groups....
Background/Aim: Only 30-50% of patients with sentinel lymph node (SLN) metastases present further axillary metastases. Therefore, up to 70% positive SLN are overtreated by dissection (AD) and may suffer from complications such as sensory disturbances or lymphedema. According the current S3 guidelines, AD can be avoided in a T1/T2 tumor if breast-conserving surgery subsequent tangential irradiation is performed no more than two SLNs affected. Additionally, use nomograms, that predict...
The aim of this study was to evaluate the long-term efficacy a single ultrasound-guided high-intensity focused ultrasound (US-HIFU) treatment in patients with breast fibroadenoma (FA) terms volume and pain reduction as well palpation findings. From december 2013 until november 2014 27 women symptomatic FA were treated one HIFU-session. Follow-up visits performed after 7 days, 6 months 1, 2, 3 5 years clinical examination ultrasound. One year procedure, core needle biopsy residual lesion...
Zielsetzung: Die makroskopische Komplettresektion ist ein entscheidender prognostischer Faktor in der operativen Therapie des Ovarialkarzinoms (OC). Ziel dieser Arbeit die Analyse und Charakterisierung Ovarialkarzinoms, insbesondere Bezug auf eine radikale Oberbauchchirurgie, im fortgeschrittenen Stadium besondere Bedeutung zum Erreichen einer makroskopischen zukommt.
Abstract Purpose Clip-marking of axillary lymph nodes with initial biopsy-confirmed metastasis is required for targeted dissection (TAD), which includes sentinel node (SLND) and selective localization removal the clipped node. There have been several studies examined feasibility TAD in routine clinical use. In this context, optimal clip visualisation was noted as one crucial limiting factors. We, therefore, evaluated sonographic detectability 10 different commercially available markers...
Hintergrund: Thermochirurgische Therapieverfahren von benignen Tumoren der Brust gewinnen immer mehr an Bedeutung. Die Eingriffe können ambulant unter Lokalanästhesie durchgeführt werden und führen zu keinen ästhetischen Veränderungen.
Hintergrund: Thermochirurgische Behandlungen symptomatischer Fibroadenome der Brust stellen zunehmend eine Alternative zur Exzisions- oder Vakuumsaugbiopsie dar. Bei sonographisch gesteuerten HIFU-Methode wird durch gebündelte Ultraschallwellen das Gewebe erhitzt und zerstört. Die Eingriffe können ambulant, ohne Hautinzision ästhetische Beeinträchtigungen durchgeführt werden.
Der Pena-Shokeir-Phänotyp (PSP) ist gekennzeichnet durch multiple Ankylosen, Kamptodaktylie, Gesichtsdysmorphien und Lungenhypoplasie bei Hydramnion. Die zugrundeliegende neuromuskuläre Störung führt eine fetale Hypokinesie-Akinesie zur Entwicklung dieses an sich unspezifischen Phänotyps Ausbildung einer therapeutisch nicht behebbaren respiratorischen Insuffizienz mit früher postnataler Mortalität. Schwere zentralnervöse Anomalien werden in der Literatur knapp einem Drittel beschriebenen...
Abstract Purpose Preoperative risk stratification of newly diagnosed endometrial carcinoma (EC) patients has been hindered by only moderate prediction performance for many years. Recently ENDORISK, a Bayesian network model, showed high predictive performance. It was the aim this study to validate ENDORISK applying model population-based case series EC patients. Methods applied retrospective cohort women surgically treated from 2003-2013. Prediction accuracy LNM as well 5-year DSS...
<h3>Objectives</h3> Human papillomavirus (HPV) related cervical cancer is the fourth most frequent in women worldwide. Currently patient follow-up and therapy monitoring solely based on clinical examination cross-sectional imaging. The aim of this study was to investigate potential use HPV cell-free circulating DNA (cfDNA) plasma samples patients with cancer. <h3>Methods</h3> In proof-of-concept cfDNA levels were measured using a highly sensitive Next-Generation-Sequencing-based approach...