A5077448222- Vitamin D Research Studies
- Bone health and osteoporosis research
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Vitamin C and Antioxidants Research
- Bone health and treatments
- Clinical Laboratory Practices and Quality Control
- Hip and Femur Fractures
- Thyroid Disorders and Treatments
- Biomedical and Engineering Education
- Innovations in Medical Education
- Kidney Stones and Urolithiasis Treatments
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Gestational Diabetes Research and Management
- Menstrual Health and Disorders
- Obesity, Physical Activity, Diet
- Neonatal Health and Biochemistry
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Therapeutic Uses of Natural Elements
- Adrenal Hormones and Disorders
Aga Khan University
2016-2025
University of Connecticut
2023-2024
Icahn School of Medicine at Mount Sinai
2024
Aga Khan University Hospital
1998-2024
UConn Health
2023-2024
Universidad Cristiana Autónoma de Nicaragua
2024
Hamdard University
2024
Armed Forces Institute of Pathology
2024
Indus Hospital
2023
Bridge University
2020-2023
OBJECTIVE Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism unknown. We examined associations of gestational mellitus (GDM) not confounded by treatment glycemia the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO Follow-up Study (FUS) included 4,160 children ages 10–14 years who completed all or part an oral tolerance test (OGTT) whose mothers had a 75-g OGTT at ∼28 weeks gestation...
This study examined associations of maternal glycemia during pregnancy with childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort.
Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with anthropometrics explore whether these measures mediate maternal midpregnancy glucose BMI adiposity.Data on mother/offspring pairs (N = 4,832) from the epidemiological Hyperglycemia Adverse Pregnancy Outcome (HAPO) Study HAPO Follow-up (HAPO FUS) were analyzed. Linear regression used study between anthropometrics....
Guidelines for doctors managing osteoporosis in the Asia-Pacific region vary widely. We compared 18 guidelines similarities and differences five key areas. then used a structured consensus process to develop clinical standards of care diagnosis management improving quality care. Minimum assessment are needed (AP) inform practice (CPGs) improve present framework these describe its development. conducted comparative analysis existing CPGs AP using "5IQ" model (identification, investigation,...
Abstract Background Artificial intelligence (AI) is gradually transforming the practises of healthcare providers. Over last two decades, advent AI into numerous aspects pathology has opened transformative possibilities in how we practise laboratory medicine. Objectives this study were to explore could impact clinical practices professionals working Clinical Chemistry laboratories, while also identifying effective strategies medical education facilitate required changes. Methods From March...
To compare the results of a chemical method kidney stone analysis with Fourier transform infrared (FT-IR) spectroscopy.Kidney stones collected between June and October 2015 were simultaneously analyzed by FT-IR methods.Kidney (n=449) from patients 1 to 81 years old. Most adults, only 11.5% children (aged 3-16 years) 1.5% aged <2 years. The male female ratio was 4.6. In calcium oxalate type, monohydrate (COM, n=224), most common crystal, followed uric acid dihydrate (COD, n=83). children,...
Background The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods A matched case control study was conducted two hospitals Pakistan to evaluate the association (serum 25-hydroxyvitamin D) concentrations, supplementation sun exposure with Pakistani women. total 411 newly diagnosed histologically confirmed primary cases were enrolled 784 controls, free any other cancers, by age (year birth ± 5 years), residence same geographic...
Objectives: The objectives of this study were to determine the prevalence anti-β2glycoprotein-1 antibodies (anti-β2GPI) in Pakistani patients clinically suspected have antiphospholipid syndrome (APS) and assess their association with clinical manifestations. Introduction: is a complex disorder characterized by recurrent thrombotic obstetric complications. Methods: An analytical cross-sectional was conducted at Aga Khan University Hospital from January June 2022, after obtaining ethical...
Objective This study aimed to verify the methods used for biotinidase deficiency (BTD) assays, including fluorometric and colorimetric techniques, measure (BT) activity in dried blood spots (DBS) serum samples, explore clinical spectrum of patients with BTD based on low BT activity. Methods A cross-sectional was conducted at Newborn Screening Lab, Aga Khan University, Karachi, following ethical approval from August 2021 December 2024. The three phases. Phase 1 consisted verification...
Introduction Children with beta-thalassemia major (β-TM) commonly experience metabolic bone diseases. Understanding fibroblast growth factor 23 (FGF-23) levels in these children can shed light on phosphate dysregulation. This study aimed to assess changes homeostasis and associated factors, including FGF-23 explore relationships between iron overload, FGF23 levels, phosphorus regulation for clinical management of disorders, β-TM. Methods 143 β-TM patients (57.3% male, median age 12 years)...
The purpose of this communication was to assess the clinical effectiveness a newborn screening (NBS) programme for congenital hypothyroidism (CH) in tertiary care centre. This cross-sectional study conducted from January 2019 December 2023. Thyroid-stimulating hormone (TSH) on dried blood spot (DBS) specimens collected after 24 hours birth with >10 mIU/L further confirmed by testing serum TSH and FT4, CH cases were referred paediatric endocrinologist management. During period, coverage NBS...
Abstract Background Diagnosis of autism spectrum disorder (ASD) is generally made phenotypically and the hunt for ASD-biomarkers continues. The purpose this study was to compare urine organic acids profiles ASD versus typically developing (TD) children identify potential biomarkers diagnosis exploration etiology. Methods This case control performed in Department Pathology Laboratory Medicine collaboration with Pediatrics Child Health, Aga Khan University, Pakistan. Midstream collected first...
Vitamin D deficiency has been identified as a major public health problem worldwide. Sunlight is the main source of vitamin and its measurement using dosimeters expensive difficult for use in population-based studies. Hence, aim this study was to develop validate questionnaires assess sunlight exposure healthy individuals residing Karachi, Pakistan.Two with seven important items assessment were developed. Fifty four adults enrolled based on their reported (high = 17, moderate 18, low 19)...
Introduction Postgraduate medical trainees (PGs) in developing nations face various educational hurdles due to limited access quality resources and training facilities. This study aimed assess the effectiveness of e-learning, particularly Massive Open Online Courses (MOOCs), within postgraduate education. It involved development a customized online course focused on osteoporosis for PGs an examination their perspectives preferences concerning learning methods like Virtual Learning...
Healthcare workers face greater risks for mental health conditions and chronic stress due to the demanding nature of their roles. The COVID-19 pandemic exacerbated these challenges increased vulnerabilities long-term conditions. present study adapts an existing resilience-based educational workshop program address time constraints unique needs healthcare workforce in a post-COVID-19 world. Expanded from its initial focus on resilience, curriculum incorporates psychoeducation common issues....
This study aimed to determine the publication rate of free paper abstracts presented by postgraduate (PG) trainees and reasons for non-publication. A mixed methods was conducted. PG presenting papers at Pakistan Society Chemical Pathologist conferences from 2012 2018 were included. Three databases searched identify if published or not. The trainee authors not as full manuscript, surveyed barriers challenges in publishing a manuscript.The average manuscript 51.8% (n = 93/177) trainees....