A5044198893- Kidney Stones and Urolithiasis Treatments
- Cancer-related Molecular Pathways
- Sperm and Testicular Function
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Bee Products Chemical Analysis
- Connexins and lens biology
- Cancer Immunotherapy and Biomarkers
- Ovarian function and disorders
- Single-cell and spatial transcriptomics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Pediatric Urology and Nephrology Studies
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
- Fish Biology and Ecology Studies
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- Wound Healing and Treatments
- Aquaculture Nutrition and Growth
- Vitamin D Research Studies
- Tendon Structure and Treatment
- Corneal Surgery and Treatments
Pakistan Atomic Energy Commission
2025
Ziauddin University
2016-2024
Creative Commons
2023
Government of Pakistan
2022
Ziauddin Hospital
2021
Aga Khan University
2009-2012
Tongji Hospital
2012
Huazhong University of Science and Technology
2012
Karolinska Institutet
2012
Syracuse University
2012
Objective: To compare the efficacy of clomiphene and Letrozole in induction ovulation patients with primary ovarian sub-fertility. Methodology: This was a Randomized control trial study carried out at Dow University Hospital Karachi, Ojha Campus, Karachi after approval synopsis from February 2016 to January 2017. The required sample size 164 (82 group 82 CC group). Non-probability consecutive sampling technique used. Females 18-40 years irrespective weight, marriage, duration sub-fertility...
The high-throughput analysis of circulating microRNAs (miRNAs) is an active area biomarker research. oral cancer remains a common among Pakistani males that continues to present at advance stage, thus exhibiting poor survival. MiRNA 21 (miR-21) the most consistently over-expressed miRNA in different types tumor tissues. However, information regarding expression miR-21 plasma be resolved. Therefore, study was designed investigate if expressed patients with cancer, and further explore its...
Many proteins displayed differential expression (either up- or down-regulation) when proteome of migrating and non-migrating epithelium was assessed using 2-DE ESI-Q-TOF MS/MS. From the up-regulated set, we have identified for first time a 69-kDa albumin precursor protein with four peptides sequences 70-kDa heat shock (hsp70) one peptide in active phase cell migration (48 h) during healing process. Western blot analysis used to further characterize these at different phases (24, 48 72...
Salinity is one of the most critical environmental parameters regarding fish physiology, modifying food intake and growth performance in many species. The present study has investigated effects different salinity levels on performance, feeding survival Asian seabass Lates calcarifer juveniles. juveniles were reared at 0 (T1), 5 (T2), 22 (T3), 36 (T4), 42 (T5) ppt salinity. Approximately eight hundred thirty individuals with an average weight 1.24±0.52 g randomly distributed (166 fish/Tank)...
The difficulties encountered in surgical spermatozoa retrieval for intracytoplasmic sperm injection procedure azoospermic men have stressed the dire need a robust biomarker prediction of retrieval. Data highlighted role JMJD1A (Jumonji domain-containing 1A), histone H3K9 demethylase, and other nuclear proteins, protamines (PRM) transition proteins (TNP), as biomarkers male infertility.To access successful at time by evaluating mRNA expression profile JMJD1A, TNP, PRM testicular tissue.About...
Altered protamine 1 (PRM1)/ 2 (PRM2) mRNA ratio in testicular biopsy samples correlates with sperm quality and its fertilising ability. This study is planned to assess PRM1/ PRM2 subgroups of azoospermia suggest a more reliable accurate marker for assessing nonobstructive (NOA). A cross-sectional was done on samples, taken from 106 azoospermic patients. Samples were histologically classified into subgroups: 36 obstructive (OA), two groups NOA: 41 round spermatid maturation arrest (SMA) 29...
To detect the Kras gene through liquid biopsy, a less invasive technique in diagnosed colorectal cancer patients.Cross-sectional study.Department of Oncology, Dr. Ziauddin Hospital and Bait-us-Sukoon Cancer Hospital, Karachi, from 2019 to 2020.Circulating tumor DNA (ctDNA) patients was extracted magnetic bead using MagMAX cell free kit (Thermofisher, Uk). The frequency quantified real-time polymerase chain reaction (RT-PCR) assay (qPCR). ANOVA Chi-square tests were utilised for statistical...
The present study examines the correlations between fifteen morphometric and ten meristic characters total length (TL) of males, females, combined sexes Alepes vari (Cuvier, 1833) collected from Karachi fish harbor, West Wharf Coast. Statistical analyses linear regression relationships show mostly strong (r≥0.70; p<0.05) most in sexes, except height pectoral-fin (PFH), pelvic-fin base (PelFL); whereas, were found to be constant indicate weak or negative type (r≤0.50; p>0.05) with (TL)....
Abstract Proper wound healing is dynamic in order to maintain the corneal integrity and transparency. Impaired or delayed epithelial one of most frequently observed ocular defect difficult treat. Cyclin dependen kinase (cdk), a known cell cycle regulator, required for proper proliferating migration cell. We therefore investigated role regulator cdk10, member cdk family its functional association with transcriptional factor (ETS2) at active phase migration. Our data showed that cdk10 was...
Environmental contamination with heavy metals is a threat to the organisms due their toxicity, persistence and bioaccumulation in food chains. The study was aimed assess cadmium (Cd) effect on calcium (Ca) level bones of freshwater fish Channa gachua. 42 individuals were kept into six (6) aquaria; labelled aq.0, 1, 2, 3,4 5 laboratory for treatment. Aq.0 control group aq.1, 2,3,4,5 experimental treatment solution Cd 0, 0.1ppm, 0.5ppm, 1ppm, 2.5ppm 5ppm respectively three months. After...
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein characterized by separate subunit “cyclin” that essential for their enzymatic activity. CDKs play important roles in control of cell cycle progression, division, neuronal function, epigenetic regulation, metabolism, stem renewal and transcription. However, they can accomplish some these tasks independently, without binding with cyclin kinase Thus, so far, twenty different cyclins have been reported mammalian cells. The...
A 95-day feeding study was carried out to evaluate the impact of complete replacement fish oil by plant oils in growth performance, feed consumption fatty acid and body composition juvenile rabbitfish, Siganus rivulatus. There were four treatments i.e., (fish diet), (linseed C (soybean meal diet) D (sunflower diet). The experimental trial conducted twelve 1.5-m3 fiber glass tanks (n=3). Spinefoot rabbitfish juveniles had an average initial weight 0.948 g ± 0.124 they stocked at 50 per tank....
Lungs are the second most common reported site of distant metastasis in Breast cancer after bone. Mostly studies were conducted cell lines and animal model. To date, there is no blood biomarker that could determine breast progression terms lung metastasis.The aim this study to Nidogen-1 (NID1)'s mRNA protein expressions non-invasive samples cancer, early (II) advanced stages (III & IV) naive treated groups. functional association NID1, we employed an silico analysis, STRING database version...
Background: Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of tissue biopsies however, data on liquid sparse. Purpose this study was explore prognostic relevance patients. Patients and Methods: After obtaining approval from Institutional Review Board Ziauddin University informed written consent subjects, circulating evaluated 96 OSCC cases 100 age sex matched controls via real time PCR using...
Infectious Coryza (IC) was a contagious respiratory bacterial infection in peacocks. The current study evaluated the outcomes of treating infectious coryza peacock. adult peacock at age 2 years presented with history anorexia, difficulty breathing, sticky eyes, nasal and ocular discharge, semi-solid swelling under eyes. Clinical examination confirmed depression, swollen head face, gasping, occluded eyelids, purulent discharge from eyes nostrils, moist rales, recumbency. Treatment included...