Lungs are the second most common reported site of distant metastasis in Breast cancer after bone. Mostly studies were conducted cell lines and animal model. To date, there is no blood biomarker that could determine breast progression terms lung metastasis.The aim this study to Nidogen-1 (NID1)'s mRNA protein expressions non-invasive samples cancer, early (II) advanced stages (III & IV) naive treated groups. functional association NID1, we employed an silico analysis, STRING database version...

To isolate a homogenous population of human amniotic epithelial cells (hAECs) from the membrane placenta and differentiate them into hepatic-like with help small molecules.

Glioblastoma (GBM) is a fatal astrocytic glioma with poor prognosis and treatment resistance. Repurposing potential FDA-approved drugs like anti-psychotics can address the concerns in timely cost-effective manner. Epidemiological studies have shown that patients schizophrenic using low incidence of GBM. Therefore, we aimed to investigate therapeutic atypical anti-psychotic Iloperidone (ILO) alone combination Temozolomide (TMZ) against The study assessed growth inhibitory effect ILO, TMZ,...

Objective: To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women.Methods: Hundred asymptomatic, pre-menopausal women who visited General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan 3rd March 10th November, 2015 were included in this study. The (OH)D calcium measured mammographic (MD) was assessed using automated volumetric software, Volpara Research (algorithm version 1.5.1, solutions Ltd,...

The entrepreneurial universities aim to facilitate practical knowledge students and industries foster economic development. Many ideas were put forward pioneer in the United States like Massachusetts Institute of Technology (MIT) Stanford, establish a solid patent policy, technology transfer policy Liaison between university industry. next great change occurred Western Europe, with most transforming themselves into institutions supporting entrepreneurs. last was tip iceberg i.e. newly...

ABSTRACT Background: 25-hydroxyvitamin D-1-α-hydroxylase is a key enzyme for conversion of 25-(OH)-D to 1,25-(OH)2-D and extra renally produced in various tissues. The objective the study was determine levels 1-α-hydroxylase response supplementation with vitamin D premenopausal women. Methods: This single-arm pre-post interventional study, included females (n=82) their 1-α hydroxylase were measured from peripheral blood. Vitamin supplements given α-1 through ELISA. serum below 30ng/ml...

Background: Regenerative medicine is a collaborative field that applies combined concepts of tissue engineering and cell biology to promote regeneration.Tissue regeneration initiate the emergence remedies can replace revive tissues loss organs through illness injury reduce dependency on organ transplantation.The objective was isolate homogenous population human amniotic epithelial stem cells (hAECs) determine their phenotype under live-cell imaging microscope at 1 st , 3 rd 8 th -day...

Illegal trade, White-breasted water hen, Mardan, TownsMany of the waterbird species are generally thought to be threatened mainly or at least partly by over hunting.This paper provides novel information on causal factors that lead hunting and illegal trade waterhen Amaurornis phoenicurus in a remote villages district Khyber Pakhtunkhwa, Pakistan.Data were collected adopting mix scientific approach including Participants' observations, interviews structured questionnaire.Our results showed...

Coronavirus disease 2019 (COVID-19) is a pandemic and this has infected millions of people globally now.COVID-19 caused by novel beta coronavirus strain known as severe acute respiratory syndrome 2 (SARS-CoV-2).Once SARS-CoV-2 manages to enter the body, it identifies binds angiotensin converting enzyme (ACE2) receptors through binding receptor Spike Protein (S-protein).The present study aimed investigate phytochemicals potential inhibitors domain S protein so that COVID-19 with ACE2 could be...

Background: Fibroadenoma (FA) is one of the most frequently diagnosed benign neoplasm in women. Various researches have reported increased risk breast cancer females with FA. It stems from proliferation epithelial and stromal contents terminal duct lobular units (TDLU`S) tissue, that are primary sites for histopathologic assessment which gold standard diagnosis disease. However, this method subjective possess interobserver variability. Therefore, new quantitative methods required to aid...

Aim: Comparative immunohistochemical study of expression α A Crystallin in non-cataract lenses and age-related cataract humans. Methodology: This was an observational cross sectional study. There are two groups this Group comprised 121 senile degenerative from diagnosed patients. B included 10 patients who underwent surgeries for enucleation due to trauma retinoblastoma. Lenses were fixed 10% Buffered Neutral Formalin processed make paraffin blocks. Immunohistochemistry (IHC) staining...