Objective: To evaluate the expression of estrogen and progesterone receptor status in patients carcinoma ovary endometrium. Study Design: Cross-sectional study. Place Duration Study: Department Medical Oncology Jinnah Postgraduate Centre, Karachi Pakistan, from Feb 2019 to 2020. Methodology: Seventy females age 18-70 years with histologically proven diagnosis ovarian or endometrial were included Each patient was interviewed for obtaining demographic details, medical history presenting...

Objective: To evaluate the treatment pattern i.e. either upfront surgery followed by adjuvant chemotherapy or neoadjuvant and outcomes of advance ovarian cancer in different hospitals Karachi. Study Design: observational study Place Duration Study: Oncology Department, Jinnah Postgraduate Medical Center, Karachi Pakistan, from March 2019-Sep 2020. Methodology: All females age 18-70 years with diagnosis epithelial (stage III-IV) who had received on setting another hospital came to Center mid...

Objective: To evaluate histopathological subtypes and to assess age gender wise differences in among patients with peritoneal carcinomatosis presenting at tertiary care hospital of Karachi, Pakistan. Study Design: Cross-sectional study. Place Duration Study: Medical Oncology Department, Jinnah Postgraduate Center, Karachi Pakistan, from Apr 2019 2020. Methodology: One forty less than 70 years any were enrolled. The data regarding socio-demographic factors was collected on pre-designed...

To estimate the cancer incidence by age group and gender for population of Karachi Division analyzing Cancer Registry data 2017-19.The division is 16.1 million according to national census 2017. 'Karachi Registry' which a part 'National collecting from eight major hospitals in since For outcome measures, counts standardized rates (ASIR) per 100,000 were computed groups (0-14, 15-19 ≥20 years), both genders all site/type.The denominators based on estimated at census, Counts age-standardized...

Introduction Breast cancer is a leading cause of death among women. This study aimed to evaluate the association between age and hormonal receptor status (HRS) in women with breast presented at public hospital Karachi, Pakistan. Methods A cross-sectional was conducted Department Medical Oncology, Jinnah Postgraduate Center (JPMC), Pakistan, from January 2021 August 2021. All more than 18 years confirmed diagnosis were included using non-random consecutive sampling techniques. Women who...

Abstract The pathophysiology of prostate cancer involves both genetic and acquired factors, including pathogens, such as viruses. A limited number studies have shown the presence Epstein-Barr virus (EBV) in tissues. However, there is a dearth data exploring EBV latency profile cancer, relationship with histopathological features cancer. In this study, benign prostatic hyperplasia (BPH) samples were screened for EBV, followed by characterization analysis parameters EBV-positive EBV-negative...

Abstract Background H. pylori infection has been associated with many micronutrient deficiencies. There is a dearth of data from communities nutritional deficiencies and high prevalence infection. The aim this study was to determine the impact on serum levels vitamin B 12 , folate homocysteine in patients functional dyspepsia (FD). Methods One hundred thirty-two FD undergoing gastroscopy were enrolled. analyzed for before gastroscopy. diagnosed by histopathological examination gastric...

Researchers and policy-makers have identified loss to follow-up as a major programmatic problem. Therefore, the objective of this study is quantify TB related pre-treatment follow up treatment delay in private sector health care facilities Pakistan.This was retrospective, descriptive cohort using routinely collected data from referral, diagnosis registers. Data 48 healthcare were an online questionnaire prepared ODK Collect, for period October 2015 March 2016. analysed SPSS. We calculated...

Introduction Primary care interval is the time duration from a patient’s first presentation to final diagnosis. Ewing’s sarcoma rare small round blue cell bone tumor originating neuroectoderm and undifferentiated neuroepithelial cells, having an annual incidence of approximately one case per million in United States. In this study, we analyzed age pattern among patients diagnosed with undergoing management, along associated features including involved site, regional lymphadenopathy, distant...

Background Coronary artery disease is very common in Pakistani population. Some of the studies carried out on Western populations have shown a relationship between body iron status as determined by ratio concentrations serum soluble transferrin receptor (sTfR) to ferritin and risk acute myocardial infarction (AMI). In order investigate whether increased has any with premature AMI population, case-control study was out. Methodology/Principal findings this study, 203 consecutive patients [146...

To collect and analyse epidemiologic data of all malignancies by age group gender for the Karachi population to estimate cancer incidence 5-years (2017-2021) identify major risk factors setting priorities towards control programs.Observational study. Place Duration Study: Cancer Registry (KCR) Secretariat, Pakistan Health Research Council (PHRC), JPMC, Karachi, from 2017-2021.Cancer seven tertiary care hospitals submitted KCR during study period were analysed including age, gender, date...

Gene deletions in GSTM1 and GSTT1 may result tempering the activation detoxification of several carcinogens thereby increase risk cancer pre-disposition. This study aims to investigate clinical impact glutathione-S-transferase polymorphisms on squamous cell carcinoma cervix (SCCA).The were analyzed cervical patients healthy controls. Touch down multiplex polymerase chain reaction (PCR) strategy was adopted for genotyping polymorphisms. The null genotype exhibited a significantly higher...

Introduction Breast cancer is a worldwide public health issue and primary cause of death among women. The present study aimed to assess the correlation between site stage breast with respect age females. Methods A prospective observational was conducted at Medical Oncology Department, Jinnah Postgraduate Centre, Karachi, Pakistan from May 2020 June 2021. Female patients 18 years or older confirmed diagnosis were included in study. Histopathological reports evaluated for tumor characteristics...

Abstract Several studies have shown an association between prostate carcinoma (PCa) and Epstein-Barr virus (EBV); however, none of the so far identified histopathological genetic markers cancer aggressiveness associated with EBV in PCa tissues. In this study, we used previously characterized EBV-PCR-positive (n = 39) EBV-negative 60) tissues to perform IHC-based assessment key molecular (EMT markers, AR expression, perineural invasion, lymphocytic infiltration characterization)....

Increased expression of MRP 1 in AML patients results the efflux drugs from cells, preventing patient achieving remission or potentially leading to relapse. Several studies have demonstrated that early identification ABC transporter may yield favorable outcomes.

Areca nut (commonly known as betel nut) chewing has been shown to be associated with metabolic syndrome and cardiovascular disease (CVD). The mechanism by which ingestion could lead development of CVD is not precisely known; however, dyslipidemia, hyperhomocysteinemia, hypertriglyceridemia inflammation some the potential risk factors. This study was undertaken investigate effects two dosages on homocysteinemia, components syndrome, such hypertriglyceridemia, low HDL-cholesterol, obesity...

Introduction: Gefitinib, a tyrosine kinase inhibitor (TKI), is an epidermal growth factor receptor (EGFR)-blocking drug that effective in the treatment of lung cancer with EGFR mutations; however, its benefits for head and neck cancers are uncertain. Therefore, this study aims to determine efficacy gefitinib methotrexate patients advanced-stage or recurrent cancer. Methodology: Two hundred age >18 years advanced clinical stage either IVA IVB cases were included study. Patients randomly...

Abstract Aim This research was designed to develop an animal model by inducing polycystic ovary syndrome (PCOS) with dehydroepiandrosterone (DHEA) and observe reproductive morphological changes after treatment vitamin D. Materials Methods Thirty pre‐pubertal female Sprague–Dawley (SD) dams were recruited. The animals distributed 10 each in control, PCOS D‐treated groups. In control group 0.2 ml of sesame oil given. administered DHEA the daily dose 6 mg/kg for 30 days. group, injected...

Introduction The frequency of breast cancer (BC) is increasing among Pakistani females. It has been estimated that one out every nine women predicted to develop BC, which the highest disease occurring rate in Asian population. study aimed evaluate factors responsible for delay diagnosis BC Sindh, Pakistan. Methodology This was conducted at Medical Oncology Department Jinnah Postgraduate Center Karachi from December 2018 June 2019. All between 17 and 80 years diagnosed with who had treatment...

The associated risk factors for the majority of patients with head and neck squamous cell carcinoma (HNSCC) are tobacco betel nut abuse, while there also seems to be a rising proportion who report no history or usage. Therefore, objective study was find out potential demographics HNSCC addicted and/or nut, as well non-addicted patients.This epidemiological conducted in Karachi Institute Biotechnology Genetic Engineering (KIBGE), University Karachi, Jinnah Postgraduate Medical Centre (JPMC)...