A5031151825- Adipokines, Inflammation, and Metabolic Diseases
- Rheumatoid Arthritis Research and Therapies
- Vitamin D Research Studies
- Obstructive Sleep Apnea Research
- Glutathione Transferases and Polymorphisms
- Pesticide Exposure and Toxicity
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
- Osteoarthritis Treatment and Mechanisms
- Gut microbiota and health
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Congenital Heart Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Enterobacteriaceae and Cronobacter Research
- Cancer-related gene regulation
- Congenital heart defects research
- Systemic Lupus Erythematosus Research
- Enzyme function and inhibition
- Cardiovascular Disease and Adiposity
- NF-κB Signaling Pathways
- Advanced Breast Cancer Therapies
University of Karachi
2016-2025
Dow University of Health Sciences
2015-2025
George Eliot Hospital NHS Trust
2024
Czech Academy of Sciences, Institute of Biotechnology
2016-2024
Institute of Biomedical and Genetic Engineering
2017-2024
Cincinnati Children's Hospital Medical Center
2023
Jinnah Medical & Dental College
2018
Czech Academy of Sciences, Institute of Physiology
2017
Karachi Medical and Dental College
2017
<ns3:p>Osteoarthritis (OA) and rheumatoid arthritis (RA) are prevalent, debilitating conditions causing significant joint pain functional impairment. OA affects over 30% of the global population, while RA impacts around 1%, with risk factors including age, sex, smoking. Both disorders frequently accompanied by psychological issues such as anxiety depression, which exacerbate physical symptoms lead to additional health problems. Fibromyalgia, often co-occurring RA, further complicates these...
This study explored the effects of natural growth promoters (phytogenic feed additives and organic acids) on animal performance, carcass characteristics, blood parameters, gut microflora composition, microbe-host interactions in broiler chickens over a 42-day feeding period. Two-hundred-fifty-day-old chicks were randomly assigned to one five treatments: (i) control diets (CON); (ii) + 40 g/tons antibiotic promoter (AB); (iii) 3 kg/tons acids (ORG); (iv) phytogenic (PHY); (v) additive...
Colorectal cancer (CRC) presents an enormous burden on cancerrelated deaths and ranks third in cancer-associated mortality both men women worldwide. 1CRC develops when stem cells at the base of colon's crypts experience genetic epigenetic alterations.Normal become cancerous because these changes, which disrupts delicate balance between oncogenes tumor suppressor genes. 1 Surgery, chemotherapy, radiation, immunotherapy, targeted therapy are routine therapies for CRC.Nonetheless, depending CRC...
Purpose: To investigate the efficacy of promising alternatives to antibiotic growth promoters (organic acids, phytobiotics, and their combinations) as feed additives in poultry feed.Methods: Different treatments were formulated with organic phytobiotics combinations, effects on blood profile, serum enzymes immunity parameters evaluated broilers at 21 42 days age.Results: Cholesterol, triglyceride HDL levels 21- 42-day old significantly (p < 0.05) affected by additives. The effect albumin...
In an epoch of escalating number antibiotic-resistance bacteria, there is a dire need to develop efficient and novel feeding strategies for animal nutrition as alternatives antibiotics. Here, implicating nutrigenomic approach, phytobiotics organic acids were used evaluate ghrelin gene expression levels, gut microflora composition, performance parameters intestinal histomorphological changes in broiler chickens. One-day-old chicks (n = 315) reared 42 days distributed randomly into five...
This study investigated the relationship between cardiorespiratory fitness (CRF) and adiposity in young adults.Data was collected from 133 students of a medical college Pakistan. The conducted on adults, aged 17-24 years, recruited Jinnah Medical & Dental College, Karachi, Aug-Dec, 2015. Queen's College Step Test to measure CRF maximal oxygen uptake (VO2max) evaluated. Anthropometric measurements (body mass index, body fat, visceral waist circumference) were taken assess adiposity....
Objective: The myokine interleukin-15 (IL-15) is capable of modifying the metabolism both skeletal and adipose tissue. This study compares change in serum levels IL-15 obese non-obese after a single session submaximal exercise.Methods: A cross-sectional was carried out at Jinnah Medical Dental College, Karachi, during Aug-Dec 2015, comprising 133 medical students (aged 17-24 years). Cardiorespiratory fitness evaluated by Queen's College Step Test. Blood obtained before just exercise...
Coronary artery disease (CAD) is a most important cause of morbidity and mortality worldwide as well in Pakistan. Recent studies have shown that the combination obesity, insulin resistance fluctuation circulating adipocytokines levels associated with pathogenesis coronary disease. Omentin-1 recently found adipocytokine highly expressed visceral adipose tissue. It has anti- inflammatory properties negatively correlated ischemic heart Therefore, this study was designed to investigate...
Objective: Biotransformation of xenobiotics is critical for their metabolism and removal from the body which carried out by xenobiotic metabolizing enzymes. Individuals carrying variants genes that encode these enzymes have an altered ability to metabolize may lead increased risk acute lymphoblastic leukemia. The current study aimed investigate impact GSTM1 GSTT1 gene deletions in causing predisposition adult ALL.Methods: case-control involved 62 ALL patients age gender matched healthy...
Coronary artery disease (CAD) is a leading cause of mortality in Pakistan and also worldwide. Vitamin D receptor (VDR) regulates the transcription many genes has significant impact on inflammation morphology cardiac cells. Genetic variation VDR gene such as TaqI polymorphism (rs731236) may have an that causes adverse effects. Accordingly, it important to determine possible association with CAD.The study included blood samples from 1016 subjects: 516 CAD patients 500 age- gender-matched...
Rheumatoid arthritis (RA) is an autoimmune disorder with unknown aetiology. Patients suffering from RA face persistent pain due to joint inflammation, and tissue destruction. Behavioural phenotyping approach target the role of different behavioural traits associated disease progression. The study aimed assess patterns decreased muscle strength in adjuvant-induced rheumatoid animal model. was conducted on male Albino Wister rats (n = 30) [Control, Vehicle, Disease groups]. After taking...
Background & Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested CAT -21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, other diseases accompanied by oxidative stress. This study was designed to investigate prevalence...
A cross-sectional study was designed to investigate the frequency of PMS, on 520 subjects selected from University Karachi (mean age 20±1.94).The PMS and menstrual cycle data individuals were collected prism calendar symptom-thermal chart for three consecutive cycles.Based observations, all grouped as control ( 208) patients (312).The (60%) with symptoms include irritability (71.05%), fatigue (86.84%), bowel constipation (36.76%) loose (17.65%), appetite up (42.65%), down (51.47%).Breast...
The genetic polymorphisms (rs708035, rs3844283) of Interleukin-1 receptor associated kinases 2 (IRAK2) is involved in the NFκB regulatory pathway. frequencies IRAK2 gene are unknown Pakistani population. Therefore, study was designed to examine association targeted single nucleotide polymorphism(s) RA patients.The participants were selected by ACR/EULAR 2010 standards. After ethical approval, blood samples patients and healthy controls collected for extraction DNA followed amplification via...
Abstract Different pesticide chemicals are used to enhance crop yield by protecting from pests. Organophosphate (OPs) and Pyrethroid (PYR) in fields of Sanghar, Sindh Pakistan. PON1 an antioxidant enzyme implicated OPs detoxification may predispose chronic exposure. This study was conducted evaluate the toxic potential active at cellular genetic levels. To examine potential, locally consumed n = 2 reference compounds organophosphate (OPs): Chloropyrifos, Malathion (PYR): Cyprmethrin,...
Taxonomic characterization of bacterial 16S rRNA gene has become an accepted norm for inference complex microbial communities and ecological shifts in gut. Recently, sequences emerged as a taxonomic marker to investigate crosstalk between gut bacteria host via variations feed. Here, broiler chickens (n = 240) were subjected dietary modulation approach substitute antibiotics with natural plant-derived products. Five experimental groups control, antibiotic growth promoter, organic acids,...