A5005864414- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Dialysis and Renal Disease Management
- Pressure Ulcer Prevention and Management
- Peripheral Artery Disease Management
- Parathyroid Disorders and Treatments
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Restless Legs Syndrome Research
- Infections and bacterial resistance
- Streptococcal Infections and Treatments
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Mycobacterium research and diagnosis
- Obstructive Sleep Apnea Research
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- Diagnosis and Treatment of Venous Diseases
- Viral-associated cancers and disorders
- Pharmacology and Obesity Treatment
- Dysphagia Assessment and Management
- Thyroid and Parathyroid Surgery
- Dermatological diseases and infestations
- Behavioral Health and Interventions
- Urticaria and Related Conditions
National Tsing Hua University
2025
E-Da Hospital
2005-2025
Linkou Chang Gung Memorial Hospital
2021-2025
I-Shou University
2010-2025
Chang Gung Memorial Hospital
2015-2023
Chang Gung University
2015-2023
Ministry of Health and Welfare
2013-2020
Kaohsiung Veterans General Hospital
2002-2005
National Taiwan Ocean University
2005
National Yang Ming Chiao Tung University
2005
<b>Objective</b> To evaluate the use of prospective screening for HLA-B*58:01 allele to identify Taiwanese individuals at risk severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. <b>Design</b> National cohort study. <b>Setting</b> 15 medical centres in different regions Taiwan, from July 2009 August 2014. <b>Participants</b> 2926 people who had an indication treatment but not taken previously. Participants were excluded if they undergone a bone marrow transplant, Han...
Sleep apnea (SA) is characterized by during sleep and associated with cardiovascular diseases an increase in all-cause mortality. Chronic kidney disease (CKD) a global health problem that has placed substantial burden on healthcare resources. However, the relationship between SA incidence of CKD not clear. This study aimed to determine whether independent risk factor for development CKD.Retrospective cohort study.National Health Insurance Research Database (NHIRD) Taiwan.A total 4,674 adult...
Abstract Although treatment for the dialysis population is resource intensive, a cost-effectiveness analysis comparing hemodialysis (HD) and peritoneal (PD) by matched pairs still lacking. After matching clinical characteristics propensity scores, we identified 4,285 of incident HD PD patients from Taiwanese national cohort during 1998–2010. Survival healthcare expenditure were calculated data 14-year follow-up subsequently extrapolated to lifetime estimates under assumption constant excess...
Objective To study the prevalence and trends of lower extremity complications diabetes over an 8-year period in a single nation. Research design methods Nationwide data for people with type 2 (T2D) diabetic foot (DFCs) were analyzed (2007–2014) from National Health Insurance Database using International Classification Diseases, Ninth Revision disease coding. The DFCs defined as ulcers, infections, gangrene, hospitalization peripheral arterial (PAD). Trends patient characteristics,...
Abstract Background Inhibiting the development and progression of diabetic kidney disease (DKD) is an important issue, but renoprotective effect metformin still controversial. Objective To assess in patients with type 2 diabetes. Methods This retrospective observational multicenter cohort study included 316 693 diabetes from 7 hospitals. After matching for age, gender, medical year, baseline estimated glomerular filtration rate (eGFR), urine protein (dipstick), glycated hemoglobin (HbA1c)...
Abstract Background Infectious gangrene of the foot is a serious complication diabetes that usually leads to certain level lower‐extremity amputation (LEA). Nevertheless, long‐term survival and factors associated with mortality in such patients have yet be elucidated. Methods A total 157 type 2 who received treatment for infectious at major diabetic center Taiwan from 2002 2009 were enrolled, whom 90 had LEAs (above ankle) 67 minor (below ankle). Clinical data during used analysis LEA, was...
Purpose: Glucose metabolism is associated with several endocrine disorders. Anti-diabetes drugs are crucial in controlling diabetes and its complications; nevertheless, few studies have been carried out involving function. This study aimed to investigate the association between anti-diabetes parameters. Patients Methods: We performed a of 180 consecutive patients type 2 who attended medical center. Laboratory measurements metabolic values parameters were assessed after stable treatment...
Background The role of uremic toxins in the progression chronic kidney disease (CKD) and novel treatments to mitigate their effects are critical areas research. This pilot study investigated efficacy a activated bamboo charcoal and/or probiotics reducing improving renal function CKD patients. Methods prospective, randomized, open, blinded end-point (PROBE) included patients with stage 3 CKD. Patients were randomly assigned one four groups: (ABC), probiotics, ABC or standard treatment for...
Hepatic angiosarcoma (HAS) is rare but often fatal. A review of literature in 1979 found that only 3% the 70 patients lived for more than 2 years, survival might have been improved over years. We conducted a retrospective study and reviewed medical records who visited teaching hospital Taiwan from January 2000 to August 2010 had pathological proof HAS. In addition, we compared those survived years or did not. Of 3503 with primary liver cancer identified, 9 HAS, whom 3 (33.3%) more. One 24...
To evaluate the effect of limb preservation status and body mass index (BMI) on survival patients with diabetic foot ulcers (DFUs).A total 1346 treated for limb-threatening DFUs at a major center in Taiwan from 2002 to 2009 were tracked until December 2012. The classified into three groups: limb-preserved (n=858), minor lower-extremity amputation (LEA) (n=249), LEA (n=239). Clinical data during treatment used analysis.With 729 deaths, median time (MST) was 6.14 (95% CI 5.63-6.65) years....
Targeting interventions to an individual’s readiness modify lifestyle factors, specifically diet and exercise behaviors, may delay chronic kidney disease (CKD) progression. This study examined the effects of a targeted Lifestyle Modification Program based on change health-promotion renal protection knowledge, physical indicators patients with early CKD. A repeated-measures design randomized 160 CKD from four southern Taiwan outpatient nephrology clinics into control intervention groups. Data...
Parathyroidectomy is recommended by the clinical guidelines for dialysis patients with unremitting secondary hyperparathyroidism (SHPT). However, survival advantage of parathyroidectomy debated because selection bias in previous studies. To minimize potential present nationwide cohort study, we enrolled only who had undergone radionuclide parathyroid scanning to ensure all severe SHPT. The parathyroidectomized were matched controls based on propensity score parathyroidectomy. Mortality...
<i>Background:</i> Intradialytic hypotension (IH) has been long recognized as a common complication during hemodialysis (HD) therapy, but few studies have discussed IH-related myocardial injuries and the long-term prognosis of patients prone to IH (HP). <i>Methods:</i> We conducted prospective study on 70 chronic HD who had no recent occurrences acute coronary artery syndrome. The were divided into two groups: HP (n = 29) resistant 41). While they underwent we...
The Kidney Disease Quality of Life-36 Questionnaire (KDQOL-36™), modified by RAND, has been widely used for measurement quality life among hemodialysis or peritoneal dialysis patients. purpose this study was to refine and evaluate, using confirmatory factor analysis, the structure KDQOL-36™ when questionnaire evaluate chronic kidney disease patients in Stages 1 5 Taiwan. psychometric properties translated version were determined Mandarin-speaking adults (N = 428). Because sample data did not...
Abstract Background Diabetic foot infection (DFI) is a limb- and life-threatening complication for diabetic patients needing immediate comprehensive treatment. Early referral of DFI to center recommended but there appears limited validated evidence, with the association between time clinical outcomes preservation or in-hospital mortality still lacking. Methods This retrospective research studied consecutive type 2 treated at major in Taiwan from 2014 2017. Six hundred sixty-eight presented...
<i>Background/Aim:</i> Uremic patients are at an increased risk of being affected by tuberculosis (TB). Periodical tuberculin skin tests were suggested to detect TB-infected patients. These replaced chest radiographs in endemic areas like Taiwan. However, almost 50% the TB incidence dialysis was extrapulmonary. In this study, we tried investigate value areas. <i>Methods:</i> The recruited from our unit. Purified protein derivative (PPD) and control with antigens for...
Abstract Background Glycemic monitoring has become critical during the COVID-19 pandemic because of poor prognosis in diabetes. Vaccines were key reducing spread infection and disease severity but data lacking on effects blood sugar levels. The aim current study was to investigate impact vaccination glycemic control. Methods We performed a retrospective 455 consecutive patients with diabetes who completed two doses attended single medical center. Laboratory measurements metabolic values...
We report an outbreak of ciguatoxin poisoning after barracuda fish ingestion in southern Taiwan. Three members a family developed nausea, vomiting, watery diarrhea, and myalgias about 1 hour eating three to ten eggs fish. Numbness the lips extremities followed gastrointestinal symptoms 2 hours ingestion. Other manifestations included hyperthermia, hypotension, bradycardia, hyperreflexia. Bradycardia persisted for several days, one patient required continuous infusion intravenous atropine...
Diabetic foot infection (DFI) is a major complication of diabetic that lead to nontraumatic lower-extremity amputation (LEA). Such distal the body having systemic inflammatory response syndrome (SIRS) rarely reported. Consecutive patients treated for limb-threatening DFI in center Taiwan were analyzed between years 2014 2017. Clinical factors, laboratory data, perfusion, extent, depth, and sensation (PEDIS) wound score 519 subjects with grade 3 203 presenting SIRS (28.1%) compared. Major LEA...
Background . Peritoneal dialysis (PD) can induce fibrosis and functional alterations in PD patients’ peritoneal membranes, due to long-term unphysiological dialysate exposure, partially occurring via triggering of epithelial-to-mesenchymal transition (EMT) mesothelial cells (MCs). Vitamin D ameliorate these negative effects; however, the mechanism remains unexplored. Therefore, we investigated its possible links MCs EMT inhibition. Methods was established Sprague-Dawley rats by chlorhexidine...