Chien‐Liang Chen

ORCID: 0000-0002-9508-8396
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About
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Research Areas
  • Dialysis and Renal Disease Management
  • Parathyroid Disorders and Treatments
  • Renal Diseases and Glomerulopathies
  • Chronic Kidney Disease and Diabetes
  • Ion Transport and Channel Regulation
  • Pharmacological Effects and Toxicity Studies
  • Bone health and treatments
  • Vasculitis and related conditions
  • Renal and Vascular Pathologies
  • Quantum and electron transport phenomena
  • Acute Kidney Injury Research
  • Vitamin D Research Studies
  • Diabetes Treatment and Management
  • Systemic Lupus Erythematosus Research
  • Retinal and Optic Conditions
  • Renal and related cancers
  • Organ Donation and Transplantation
  • Dementia and Cognitive Impairment Research
  • Kidney Stones and Urolithiasis Treatments
  • Infective Endocarditis Diagnosis and Management
  • Physics of Superconductivity and Magnetism
  • Central Venous Catheters and Hemodialysis
  • Housing Market and Economics
  • Atrial Fibrillation Management and Outcomes
  • Potassium and Related Disorders

Beijing Tongren Hospital
2025

Capital Medical University
2025

National Yang Ming Chiao Tung University
2014-2024

Kaohsiung Veterans General Hospital
2015-2024

National Sun Yat-sen University
2021-2024

Overseas Chinese University
2024

Royal Adelaide Hospital
2023

The University of Adelaide
2023

National Chi Nan University
2000-2022

Chang Gung University
2017-2020

Chronic kidney disease (CKD) is a major risk factor for valvular heart (VHD). Mitral annular and aortic valve calcifications are highly prevalent in CKD patients commonly lead to stenosis regurgitation, as well complications including conduction system abnormalities endocarditis. VHD, especially mitral regurgitation stenosis, associated with significantly reduced survival among patients. Knowledge related VHD the general population not always applicable because pathophysiology may be...

10.1016/j.kint.2019.06.025 article EN cc-by-nc-nd Kidney International 2019-09-19

Denosumab is widely used for bone diseases with increased resorption. Its effectiveness in patients severe secondary hyperparathyroidism on dialysis unclear. This study aimed to evaluate the efficacy and safety of denosumab who are dialysis. 6-month prospective, open-labeled evaluated 12 (five women, seven men; mean age 53.5±3.8 y). All had intact PTH (iPTH; > 1000 pg/mL), low mass (T-score < −1.0 SD), pain were poor surgical candidates. Serum calcium, phosphorus, alkaline phosphatase (AP),...

10.1210/jc.2014-1154 article EN The Journal of Clinical Endocrinology & Metabolism 2014-03-26

Secondary hyperparathyroidism (SHPT) may worsen with administration of denosumab in chronic renal failure patients low bone mass.This study aimed to evaluate the short-term effect coadministration calcitriol and on PTH secretion parathyroid structure incidence adverse effects SHPT was a 24-week, open-label at Kaohsiung Veterans General Hospital Kaohsiung, Taiwan.Dialysis (intact hormone [iPTH] > 800 pg/mL) mass (T score < -2.5) were enrolled.Patients received (60 mg) doses adjusted achieve...

10.1210/jc.2015-1259 article EN The Journal of Clinical Endocrinology & Metabolism 2015-05-08

Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases, and neuroinflammation has been identified as its key pathological characteristics. Triggering receptors expressed on myeloid cells-1 (TREM-1) amplify inflammatory response play a role in sepsis cancer. Recent studies have demonstrated that attenuation TREM-1 activity produces cytoprotective anti-inflammatory effects macrophages. However, no study examined neurodegeneration. We showed LP17, synthetic...

10.3389/fnins.2019.00769 article EN cc-by Frontiers in Neuroscience 2019-08-02

Falling is a serious issue among elderly community dwellers, often resulting in disability. We aimed to investigate the risk factors for falls dwellers.We recruited 232 participants from multiple learning and care centers, who provided their information through questionnaires. They were divided into two groups, according falling events after 1-year follow-up. Univariate multivariate logistic regressions used statistical analysis.A total of 64 reported fall at The group comprised older single...

10.3390/ijerph18179356 article EN International Journal of Environmental Research and Public Health 2021-09-04

The induction of hepatic alpha 2u-globulin synthesis by glucocorticoids in isolated hepatocytes occurs via an increase the level its mRNA as measured cell-free translation and hydbridization to cDNA probe. To explore whether this is a direct or indirect consequence interaction dexamethasone-receptor complex with genome, requirement for ongoing protein was examined. Concentrations cycloheximide too low prevent precursor incorporation into total poly(A)-containing RNA do hormonal mRNA....

10.1073/pnas.76.6.2669 article EN Proceedings of the National Academy of Sciences 1979-06-01

Summary Objective Secondary hyperparathyroidism and its associated abnormalities in mineral metabolism haemodynamic changes increase the cardiovascular risk patients with end‐stage renal disease ( ESRD ). Our objective was to determine association of parathyroidectomy PTX ) major events nondiabetic dialysis severe secondary SHPTH Design Patients We performed a cohort study fifty‐three who were treated maintenance haemodialysis had intact parathyroid hormone PTH levels &gt; 800 pg/ml....

10.1111/cen.12333 article EN Clinical Endocrinology 2013-10-08

Hyperkalemia increases the risk of sudden cardiac death (SCD) in hemodialysis patients. Our objective was to determine association between administering low potassium dialysate hyperkalemic patients and SCD.We conducted a retrospective cohort study with undergoing maintenance from May 1, 2006, through December 31, 2013. The composition adjusted over time according monthly laboratory results. A 1.0 mEq/L applied predialysis hyperkalemia (>5.5 mEq/L) included as time-dependent confounding...

10.1371/journal.pone.0139886 article EN cc-by PLoS ONE 2015-10-06
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