A5101637753- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Patient Safety and Medication Errors
- Medicinal Plants and Bioactive Compounds
- Neurosurgical Procedures and Complications
- Erythrocyte Function and Pathophysiology
- Influenza Virus Research Studies
- Traditional Chinese Medicine Studies
- Bacterial Infections and Vaccines
- Syphilis Diagnosis and Treatment
- Minimally Invasive Surgical Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
Peking University
2025
Peking University Third Hospital
2025
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2021-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Southern University of Science and Technology
2022
Jinan University
2022
University of Pennsylvania
2018
Hua Hong Semiconductor (China)
2011
Nanchang University
2009
Abstract Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human ortholog receptor, leukocyte (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages during by binding with ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific...
The island sign is a predictor of hematoma expansion and worse outcomes in patients spontaneous primary intracerebral hemorrhage (ICH). biological mechanism the remains unclear, but its presence might be influenced by underlying vasculopathy related to Apolipoprotein E (APOE) genotypes. Therefore, we aimed research association between APOE genotypes sign. We enrolled with supratentorial ICH multicenter cohort northern China baseline noncontrast CT images performed within 14 days after...
Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) important regulator in T2D, but the role ANGPTL8 diabetes-associated dysfunction remains unknown. Here, we explored through its interaction paired immunoglobulin-like receptor B (PirB) central nervous system.
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays key role oxidation; however, regulatory mechanism of subcellular localization remains poorly understood. Here, we identify an endosomal trafficking component sortilin (encoded by Sort1) adipose tissues that shows dynamic expression during beige facilitates translocation ACSL1 from...
Background. Because hepatocyte transplantation has been considered to be an attractive method treat acute liver failure (ALF), efficient recovery of hepatocytes and maintenance differentiated functions is extreme importance. We here report the usefulness antiapoptotic pentapeptide V5, composed Val-Pro-Met-Leu-Lys, in monkey cultures. Methods. evaluated albumin production, metabolizing abilities ammonia, lidocaine, diazepam cultured with V5. The protein expression apoptosis-associated...
Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate determining the efficacy of in general paresis (GP) remains unknown. We retrospectively reviewed data from 105 GP patients, who were divided into two groups (62 CSF RPR+ patients and 43 RPR- patients) according reactive RPR status CSF. Clinical assessment included Mini-Mental State Examination...
Abstract Aim To examine the effects of thiazolidinedione (TZD) pioglitazone on reducing ketone bodies in non‐obese patients with T2DM treated sodium‐glucose cotransporter‐2 (SGLT2) inhibitor canagliflozin. Methods Crossover trials two periods, each treatment period lasting 4 weeks, a 4‐week washout period, were conducted. Participants randomly assigned 1:1 ratio to receive combined canagliflozin (PIOG + CANA group) versus monotherapy (CANA group). The primary outcome was change (Δ)...
We present a case involving an 85-year-old man with acute confusion and new onset seizure following 1-week history of respiratory prodrome. This report describes influenza B-related meningoencephalitis supported by evidence B infection temporal relation the neurological event illness in absence other identifiable cause. Diagnosis is guided cerebrospinal fluid profile nasopharyngeal PCR. Treatment largely supportive effect vaccination on prevention this complication remains unclear.
<title>Abstract</title> Obesity and its related metabolic disorders are caused by an imbalance between homeostatic energy consumption expenditure. Brown beige adipose tissues have been shown to be protective against these diseases due their critical roles in non-shivering thermogenesis; additionally, adrenergic innervation of cells promotes lipolysis fatty acid oxidation<sup>1</sup>. A key enzyme promoting oxidation tissues, particularly response cold-stimulus, is mitochondrial acyl-CoA...
Abstract Background Gancao Nurish Yin (GCNY) decoction has been applied to clinical rheumatoid arthritis (RA) patients and it had shown effectiveness not only in disease activity controlling but also on improving patients’ physical status. However, its mechanism of function investigated. Metabolic perturbations have associated with RA targeting the metabolic profile is one ways manage disease. The aim this study was observe effect GCNY changes human tumor necrosis factor alpha (hTNF-α)...
Abstract Objective Gancao Nourish-Yin Decoction (GNYD) has been applied to clinical rheumatoid arthritis (RA) patients, and it had shown effectiveness not only in disease activity controlling but also improving patients' physical status. However, its mechanism of function investigated. Metabolic perturbations have associated with RA, targeting the metabolic profile is one ways manage disease. The aim this study observe effect GNYD on changes human tumor necrosis factor α (hTNF-α) transgenic...
Abstract Inhibition of immunocyte infiltration and activation has been proven to effectively ameliorate hepatic inflammation fibrosis in nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) its human orthologue receptor, leukocyte (LILRB2), are immune-inhibitory receptors with unknown roles NASH. Here, we demonstrate that PirB/LILRB2 regulates the migration macrophages NASH pathogenesis fibrogenesis by binding NASH-associated ligand angiopoietin-like protein 8...