A5007888889- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Protein Hydrolysis and Bioactive Peptides
- Phytase and its Applications
- Enzyme Production and Characterization
- Epigenetics and DNA Methylation
- Lysosomal Storage Disorders Research
- CRISPR and Genetic Engineering
- Photochromic and Fluorescence Chemistry
- Chromosomal and Genetic Variations
- Hippo pathway signaling and YAP/TAZ
- Mosquito-borne diseases and control
- Photoreceptor and optogenetics research
- Tissue Engineering and Regenerative Medicine
- Nuclear Receptors and Signaling
- Biomedical Ethics and Regulation
- Protist diversity and phylogeny
- Retinal Diseases and Treatments
- Plant and Fungal Interactions Research
- Endoplasmic Reticulum Stress and Disease
- Amyotrophic Lateral Sclerosis Research
- Calcium signaling and nucleotide metabolism
Pfizer (United States)
2020
University of California, San Diego
2015-2020
Sanford Burnham Prebys Medical Discovery Institute
2013-2014
University of Florida Health
2008-2014
The University of Adelaide
2011
Australian Dental Association
2011
University of Florida
2008-2009
Ministry of Natural Resources
2005
Xiamen University
2003
Significance Genome-wide identification of changes in the expression large intergenic noncoding RNAs (lincRNAs) a classical model innate immune cell activation revealed panel 159 lincRNAs that were highly modulated stimulated THP1 macrophages. One lincRNAs, named TNFα and heterogenous nuclear ribonucleoprotein L (hnRNPL) related immunoregulatory LincRNA (THRIL), was essential for induction TNFα, functions through (RNP) complex with hnRNPL, plays an important role as regulator physiological...
Lysosomes are acidic organelles essential for degradation and cellular homoeostasis recently lysosomes have been shown as signaling hub to respond the intra extracellular changes (e.g. amino acid availability). Compounds including pharmaceutical drugs that basic lipophilic will become sequestered inside (lysosomotropic). How cells lysosomal stress associated with lysosomotropism is not well characterized. Our goal assess identify pathways involve in changes. Eight chemically diverse...
Wada N, Wang B, Lin N-H, Laslett AL, Gronthos S, Bartold PM. Induced pluripotent stem cell lines derived from human gingival and periodontal ligament fibroblasts. J Periodont Res 2011; 46: 438–447. © 2011 John Wiley & Sons A/S Background Objective: Human induced (iPS) cells, which have similar properties to embryonic (hES) been generated neonatal adult dermal fibroblasts by reprogramming. iPS cells high pluripotency differentiation potential, may be a potential autologous source for future...
Abstract Zika virus ( ZIKV ) is an emerging flavivirus, which when passed through vertical transmission from mother to developing fetus can lead developmental abnormalities, including microcephaly. While there mounting evidence that suggests a causal relationship between infection and microcephaly, the mechanisms by induces these changes remain be elucidated. Here, we demonstrate of neural stems cells, both in vitro vivo , macroautophagy enhance viral replication. At same time, downregulates...
Formation of facultative heterochromatin at specific genomic loci is fundamentally important in defining cellular properties such as differentiation potential and responsiveness to developmental, physiological, environmental stimuli. By the nature their formation, repressive histone marks propagate until chain reaction broken. While certain active promoters can block propagation heterochromatin, there are also specialized DNA elements, referred chromatin barriers, that serve demarcate...
Receptor associated protein (RAP) functions in the endoplasmic reticulum (ER) to assist maturation of several membrane receptor proteins, including low density lipoprotein receptor-related (LRP) and 11 (SorLA/LR11). Previous studies cell mouse model systems have demonstrated that these proteins play roles metabolism amyloid precursor (APP), processes involved generation, catabolism deposition beta-amyloid (Abeta) peptides.Mice transgenic for mutant APPswe presenilin 1 (PS1dE9) were mated...