A5035244008- 14-3-3 protein interactions
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Ziziphus Jujuba Studies and Applications
- Pharmacological Effects of Natural Compounds
- Genetic Associations and Epidemiology
- Extracellular vesicles in disease
- Medicinal Plant Pharmacodynamics Research
- Axon Guidance and Neuronal Signaling
- Neuroscience of respiration and sleep
- Protein Tyrosine Phosphatases
- Schizophrenia research and treatment
- Acupuncture Treatment Research Studies
- Genetic Syndromes and Imprinting
- Synthesis and Reactions of Organic Compounds
- Herbal Medicine Research Studies
- Ferroptosis and cancer prognosis
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Osteoarthritis Treatment and Mechanisms
- Polysaccharides Composition and Applications
- Endoplasmic Reticulum Stress and Disease
Wuhan Sports University
2024-2025
Qiqihar Medical University
2013-2024
Lincoln University College
2024
Nanchang University
2024
Suzhou Traditional Chinese Medicine Hospital
2024
Heilongjiang University
2024
Peking University
2023
Peking University Third Hospital
2023
Zhongnan Hospital of Wuhan University
2021
Wuhan University
2021
Aims: To evaluate the efficacy of stromal vascular fraction (SVF) in treating osteoarthritis (OA). Background: OA is a common degenerative disease, most important manifestation which cartilage destruction and inflammation. The SVF mixed group multiple cells extracted from adipose tissue with certain ability to promote repair. However, biological safety human derived have not been confirmed. Methods: Seventy‐six nude rats were used this experiment. rat model was constructed anterior cruciate...
In the present study, we analyzed schizophrenia (SCZ)‑related genome‑wide association studies (GWAS) to identify genes and pathways associated with SCZ. We identified 1,098 common (1,098/9,468) 20 shared KEGG (both P<0.01) by integrating candidate from European American SCZ‑related GWAS. The related axon guidance, long term potentiation arrhythmogenic right ventricular cardiomyopathy (ARVC) were highly significant (P<10‑3). Moreover, 15 guidance pathway‑related between pathway SCZ was...
Salidroside (Sal), the main component of a famous herb Rhodiola rosea L, enhances memory performance and reduces fatigue. Therefore, this study assessed effect Sal on impairment induced by long-term intake ethanol (EtOH) in rats investigated its relevant mechanisms using gut microbiota metagenomic analysis hippocampal transcriptomic analysis.Eighteen male SD were divided into normal control group (CON group), EtOH model (Model treatment (Sal group). The Model groups intragastrically (i.g.)...
C-reactive protein (CRP) has been indicated to be associated with the pathogenesis of schizophrenia (SZ) and other psychiatric disorders. The aim this study is investigate whether peripheral blood CRP levels are risk SZ. We searched literature from databases Pubmed, Embase Cochrane Library inception November 1, 2016 for studies that reported serum or plasma in patients SZ non-SZ controls. At least two reviewers decided on eligibility extracted data included studies. Random effects...
Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing (CRF) and elicit anxiolytic actions. Semen Ziziphi Spinosae (SZS), prototypical hypnotic-sedative herb in Oriental medicine, exhibits effects during nicotine by improving amygdaloid CRF/CRF1 (CRFR1) signaling. Therefore, we evaluated the of SZS on EtOHW involvement CRF/CRFR1 N/OFQ/NOP pathways.
Gene polymorphisms of the renin–angiotensin system are involved in pathophysiology hypertension. We genotyped 4 angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism 652 patients 780 controls to examine association AGT hypertension a Northern Han Chinese population. There were significant differences distribution genotypes allele frequencies at between (both P < .01); with CC...
Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse. Semen Ziziphi Spinosae (SZS), which prototypical hypnotic‐sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders thousands of years. Thus, the present study evaluated effects aqueous extract SZS (AESZS) on NicW‐induced male rats that received subcutaneous administrations (Nic) (0.4 mg/kg, twice day) 7 d followed by 4 withdrawal. During NicW, four...
Both the positive (manifested by locomotor sensitization) and negative (withdrawal symptoms) reinforcing effects of ethanol (EtOH) involve central nitric oxide (NO) signaling. Sauchinone (a bioactive lignan in Saururus chinensis) has been shown to improve methamphetamine-induced behavioral neurochemical changes via NO signaling pathway. Thus, this study evaluated sauchinone on sensitization anxiety during EtOH withdrawal (EtOHW). Male adult Sprague-Dawley rats were treated with 1.5 g/kg/day...
As important components of positive and negative reinforcement, locomotor sensitization withdrawal anxiety following repeated exposure to nicotine (NIC) constitute crucial risk factors for relapse NIC use after abstinence. Glycyrrhiza radix (G. radix), an tonic used in traditional Oriental medicine, has not only anxiolytic effects but also reduces NIC-induced sensitization. Isoliquiritigenin (ISL), a bioactive ingredient G. radix, exhibits neuropharmacological effects, including action....
Schizophrenia (SZ) is a complex disorder caused by variety of genetic and environmental factors. Mounting evidence suggests the involvement microRNAs (miRNAs) in pathology SZ. Accordingly, current study set out to investigate possible implication miR-182/183 cluster, as well its associated mechanism progression Firstly, rat models SZ were established intraperitoneal injection MK-801. Moreover, primary hippocampal neurons exposed MK-801 simulate injury neurons. The expression or putative...
To explore the potential mechanism of electroacupuncture (EA) for vascular dementia (VD) using tandem mass tag (TMT) quantitative proteomics technology.
Schizophrenia is characterized by a complex interplay of genetic and environmental factors, leading to alterations in various molecular pathways that may contribute its pathogenesis. Recent studies have shown exosomal microRNAs could play essential roles brain disorders; thus, we sought explore the potential mechanisms through which plasma exosomes are involved schizophrenia.
Replication of genome-wide significant association SNPs in independent populations is an essential approach for identifying gene–disease relationships. Therefore, we sought to investigate the top 21 (rs10507454, rs11897156, rs11897991, rs12325203, rs12541835, rs13395322, rs1525035, rs16936892, rs17010027, rs17045859, rs17136827, rs1866525, rs2045590, rs4547758, rs4655688, rs7107438, rs761353, rs8127139, rs9312305, rs9407874 and rs9865108) from a study hypertension Mongolians. This was...
Objective To investigate the susceptibility related sites to schizophrenia through whole genome analysis combined with bioinformatics method. Methods The research was carried out by two stages.In first stage, 300 cases of and healthy controls were enrolled, 5ml peripheral venous blood drawn extract DNA.After quality control concentration adjustment ultraviolet spectrophotometer, equal mass DNA mixed into pooling for case group respectively.Genome-Wide Human SNP Array 6.0 chips used...
Objective To investigate the association between patients with schizophrenia and polymorphism in rs2030324 rs11030101 of brain derived neurotrophic factor(BDNF). Methods 100 100 normal controls were enrolled. The BDNF (rs2030324 rs11030101) allele frequency genotyped by sequencing products PCR. Genotype frequencies compared controls. Symptoms assessed using PANSS, relationship score PANSS was analyzed. Results There statistically significance schizophrenic distribution...
Objective To explore the pharmacodynamic effect of longan extract on alcohol abstinence-induced anxious behavior in rats. Methods The was concentrated to 1/3 original volume by ethanol extraction and freeze-dried powder. The SD rats were randomly divided into a blank group, model low concentration medium high group. Firstly, dependence withdrawal prepared acute intraperitoneal injection (20% W/V, 2 g/d) for 28 days; drug given gavage at (100 mg/d) , (200 concentrations (400 3 days. On...