A5071682126- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Gastric Cancer Management and Outcomes
- Orbital Angular Momentum in Optics
- Ultrasonics and Acoustic Wave Propagation
- Flow Measurement and Analysis
- Acoustic Wave Resonator Technologies
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Advanced Fluorescence Microscopy Techniques
- Advanced biosensing and bioanalysis techniques
- Electrical and Bioimpedance Tomography
- Radiomics and Machine Learning in Medical Imaging
- 3D Printing in Biomedical Research
- Ultrasound and Cavitation Phenomena
- Electrostatics and Colloid Interactions
- Landslides and related hazards
- Helicobacter pylori-related gastroenterology studies
- Advanced Sensor Technologies Research
- Electrowetting and Microfluidic Technologies
- Congenital heart defects research
Liverpool John Moores University
2018-2025
Xi'an University of Science and Technology
2023-2024
Qiqihar Medical University
2017-2021
University of Glasgow
2015-2020
Fujian Medical University
2019
University of Oklahoma Health Sciences Center
2018
University of Dundee
2009-2016
Johns Hopkins University
2016
Ninewells Hospital
2014
University of Southampton
2004-2012
Ultrasonic particle manipulation tools have many promising applications in life sciences, expanding on the capabilities of current technologies. In this paper, ultrasonic particles and cells along a microfluidic channel with piezoelectric array is demonstrated. An integrated into planar multilayer resonator structure drives toward pressure nodal plane centerline channel, then acoustic velocity maximum centered above subset elements that are active. Switching active moves trapped channel. A...
An emerging demand for the precise manipulation of cells and particles applications in cell biology analytical chemistry has driven rapid development ultrasonic technology. Compared to other technologies, such as magnetic tweezing, dielectrophoresis optical shown potential a variety applications, with its advantages versatile, inexpensive easy integration into microfluidic systems, maintenance viability, generation sufficient forces handle particles, their agglomerates. This article briefly...
Coaxial rotor helicopters have a wide range of civilian and military applications; however, the collision risk upper lower blades that comes with coaxial system remains. This paper introduces blade-tip distance measurement method based on coded ultrasonic ranging to tackle this challenge. Coded phase modulation was adopted improve rate. In paper, seven-bit M-sequences Gold codes are chosen four periods 200 kHz sine wave carriers as excitation signals, received signals filtered by bandpass...
A method was developed for the simultaneous determination of chloramphenicol (CAP), thiamphenicol (TAP), and florfenicol (FF) residues in animal tissues using gas chromatography/mass spectrometry (GC/MS) with chemical ionization source negative mode. The homogenized samples were extracted ethyl acetate extracts partitioned n-hexane to remove lipids. Further cleanup performed on a florisil cartridge purified derivatized Sylon BFT [N, O-bis (trimethylsilyl) trifluoroacetamide...
Clinical endoscopy and colonoscopy are commonly used to investigate diagnose disorders in the upper gastrointestinal tract colon, respectively. However, examination of anatomically remote small bowel with conventional is challenging. This advances miniaturization led development video capsule (VCE) allow a noninvasive manner. Available since 2001, current endoscopes limited viewing mucosal surface only due their reliance on optical imaging. To overcome this limitation submucosal imaging,...
Abstract Contactless sample confinement would enable a whole host of new studies in developmental biology and neuroscience, particular, when combined with long-term, wide-field optical imaging. To achieve this goal, we demonstrate contactless acoustic gradient force trap for light sheet microscopy. Our approach allows the integration real-time environmentally controlled experiments low photo-toxic imaging, which on variety marine animal embryos larvae. illustrate key advantages our approach,...
Lead zirconate titanate (PZT)-based piezoelectric micromachined ultrasonic transducers (PMUTs) for particle manipulation applications were designed, fabricated, characterized, and tested. The PMUTs had a diaphragm diameter of 60 μm, resonant frequency ~8 MHz, an operational bandwidth (BW) 62.5%. Acoustic pressure output in water was 9.5 kPa at 7.5 mm distance from PMUT element excited with unipolar waveform 5 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Wireless capsule endoscopy has been used for the clinical examination of gastrointestinal (GI) tract two decades. However, most commercially available devices only utilise optical imaging to examine GI wall surface. Using this sensing modality, pathology within cannot be detected. Micro-ultrasound (μUS) using high-frequency (>20 MHz) ultrasound can provide a means transmural or cross-sectional image tract. Depth is approximately 10 mm with resolution between 40–120 μm that sufficient...
Coaxial rotor helicopters have great potential in civilian and commercial uses, with many advantages, but challenges remain the accurate measurement of blades’ distance to prevent blade collision. In this paper, a tip method based on ultrasonic window phase triggering is proposed, time transmitter studied. Due complexity measured signal, bandpass filtering time-of-flight (TOF) estimation power density received signal are utilised. The tested an experimental test platform pair 200 kHz...
The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. technological–pharmacological combination capsule endoscopy ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment these throughout the GI tract. We describe a proof-of-concept UmTDD present preliminary results to demonstrate its promise an...
This paper reports the development of a two-dimensional thick film lead zirconate titanate (PZT) ultrasonic transducer array, operating at frequency approximately 7.5 MHz, to demonstrate potential this fabrication technique for microparticle manipulation. All layers array are screen-printed then sintered on an alumina substrate without any subsequent patterning processes. The thickness PZT is 139 ± 2 μm, element pitch 2.3 mm, and dimension each individual × mm2 with top electrode 1.7 mm2....
Video capsule endoscopy (VCE) is now a clinically accepted diagnostic modality in which miniaturized technology, an on-board power supply and wireless telemetry stand as technological foundations for other (CE) devices. However, VCE does not provide therapeutic functionality, research towards CE (TCE) has been limited. In this paper, route viable TCE proposed, based on multiple devices including important acoustic sensing drug delivery components. approach, initial multimodal device with...
Current clinical standards for endoscopy in the gastrointestinal (GI) tract combine high definition optics and ultrasound imaging to view lumen superficially through its thickness. However, these instruments are limited length of an endoscope only clinically available, autonomous devices able travel full GI easily offer video capsule (VCE). Our work seeks overcome this limitation with a device ("Sonopill") multimodal endoscopy, providing optical microultrasound (μUS) supporting sensors <sup...
Miniaturised ultrasound transducer arrays with integrated electronics will in future enable significant advances high resolution medical imaging and acoustic tweezing for bioscience research. However, their development has been limited by challenges scaling down conventional piezoelectric fabrication interconnection techniques. Piezoelectric thin film transducers on silicon substrates can overcome these reducing dimensional constraints facilitating integration electronics, including allowing...
Diseases which are prevalent in the gastrointestinal (GI) tract, such as Crohn's disease, a topic of increasing concern because diagnosis and specific treatment difficult may be ineffective. New techniques therefore sought after this paper describes proof-of-concept tethered capsule for targeted drug delivery (TDD) GI tract. The consists camera, illumination, channel an ultrasound (US) transducer. transducer is described detail, including comparison different piezoceramic materials that has...
To explore the influence of sample preparation methods on permeability and microstructure remolded loess, loess collected from Heifangtai was taken as research object. A total 40 sets falling-head tests were conducted using two commonly used methods, five different dry density four initial water content conditions. Additionally, electrical conductivity leachate microscopic structure samples analyzed. The results demonstrate that compared to transfer wetting method, homogeneity prepared...
Ultrasonic particle manipulation tools have many promising applications in life sciences research, expanding on the capabilities of current technologies. In this paper feasibility ultrasonic particles and cells along a microfluidic channel with an array is investigated. An integrated into multilayer resonator structure drives towards pressure nodal plane axis channel, then acoustic velocity maximum centered above driven elements. Switching active elements moves trapped channel. A 1-D coupled...
Abstract GDF1 plays an important role in left–right patterning and genetic mutations the coding region of are associated with congenital heart disease (CHD). However, variation promoter sporadic CHD its expression regulation is little known. The association was examined two case–control studies, including 1084 cases 1198 controls first study 582 615 second study. We identified one single nucleotide polymorphism (SNP) rs181317402 novel located GDF1. Analysis combined samples revealed a...