A5100385221- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- Optical Coherence Tomography Applications
- Natural product bioactivities and synthesis
- Advanced Fluorescence Microscopy Techniques
- Evaluation Methods in Various Fields
- CRISPR and Genetic Engineering
- Phytoestrogen effects and research
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Transcranial Magnetic Stimulation Studies
- Tea Polyphenols and Effects
- Atherosclerosis and Cardiovascular Diseases
- Pharmacological Effects of Natural Compounds
- Seaweed-derived Bioactive Compounds
- Receptor Mechanisms and Signaling
- Dendrimers and Hyperbranched Polymers
- Neuroendocrine regulation and behavior
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Metallurgical and Alloy Processes
- Brucella: diagnosis, epidemiology, treatment
Jiangsu University
2025
Affiliated Hospital of Jiangsu University
2025
South China University of Technology
2024
Xinjiang Institute of Materia Medica
2024
Dalian Medical University
2023
Qiqihar University
2022
Affiliated Hospital of Hangzhou Normal University
2022
Shanghai Jiao Tong University
2010-2020
Chinese People's Liberation Army
2019
People's Liberation Army No. 150 Hospital
2019
We demonstrate a compact watt-level all polarization-maintaining (PM) femtosecond fiber laser source at 1100 nm. The is seeded by an PM mode-locked employing nonlinear amplifying loop mirror. seed can generate stable pulses fundamental repetition rate of 40.71 MHz with signal-to-noise >100 dB and integrated relative intensity noise only ∼0.061%. After two-stage external amplification pulse compression, output power ∼1.47 W (corresponding to energy ∼36.1 nJ) duration ∼251 fs are obtained....
Evolutionarily conserved SCAN (named after SRE-ZBP, CTfin51, AW-1, and Number 18 cDNA)-domain-containing zinc finger transcription factors (ZSCAN) have been found in both mouse human genomes. Zscan4 is transiently expressed during zygotic genome activation (ZGA) preimplantation embryos induced pluripotent stem cell (iPSC) reprogramming. However, little known about the mechanism of underlying these processes fate control. Here, we show that Zscan4f, a representative ZSCAN proteins, able to...
The wide application of oncolytic adenovirus presents a novel therapeutic strategy for breast cancer gene therapy. Application alone achieves little curative effects on cancer. In addition, it is worth exploring the synergistic anti-tumor effect by inserting immunomodulatory factor in genome. By taking advantage highly proliferative property cancer, recombinant which could selectively kill tumor cells established under an E2F-1 promoter. Also carrying human Interleukin-15 (IL-15) gene,...
Background and Purpose Temporomandibular disorders (TMD), especially pain-related TMD, are closely related to social psychological factors. We aimed measure changes in spontaneous brain activity its functional connectivity (FC), as well FC characteristics within the mood-regulating circuits (MRC) TMD patients by resting-state magnetic resonance imaging (RS-fMRI), analyze relationship between these parameters emotional symptoms. Materials Methods Twenty-one adult thirty demographically...
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential receptor (ESR)-related we analyzed genetic variants ofESR1 in association susceptibility. We performed a meta-analysis to investigate the between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), risk. Our analysis included 44 case-control studies. For CC genotype had higher risk compared TT or CT genotype. rs2046210, AA, GA,...
Abstract Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising way for treating demyelinating diseases. However, generation scalable and autologous sources OPCs has proven difficult. We previously established chemical condition M9 that could specifically initiate neural program in mouse embryonic fibroblasts. Here we found induce the formation colonies undergo mesenchymal-to-epithelial transition at early stage reprogramming. These may represent unstable...
Tilianin (TIL), a bioactive component derived from Dracocephalum Moldavica L., has been recognized for its anti-inflammatory properties. However, effects on the Nlrp3 inflammasome within endothelial progenitor cells (EPCs) during myocardial ischemia-reperfusion injury (MIRI) remain unexplored. This study aimed to elucidate role of TIL in modulating activation under MIRI conditions. A mouse model was established assess therapeutic potential TIL. EPCs treated with at concentrations 5, 10, and...
amine oxidase inhibitor, MAOI), 具有抗抑郁效果, 但 因其副反应大、起效缓慢, 很快被三环类抗抑郁药 (tricyclic antidepressant, TCA)取代.
Bcl-xL belongs to a family of proteins which inhibit apoptosis in number stimuli including ionizing radiation. To better understand the effects and mechanisms on lymphocytes provide experimental basis treat immune injury induced by radiation, we used normal human lymphoblastoid AHH-1 cells that were engineered overexpress proteins. Our results showed overexpressed reduced time-dependent increase Reactive oxygen species (ROS) generation Bax protein expression transfected AHH1-Bcl-xL also...
This paper proposes an effective method to determine the optimal parameters settings of reflow soldering profile and helps reduce try-and-error time in practical application. Due complex nonlinear relationship between thermal process this problem, BPNN is adopted establish model for description intricate inputs outputs. According requirements profile, GA used calculate best input with its strong global research ability. Thus, a combined proposed optimization contributes reduction decision...
We demonstrate a compact watt-level all polarization-maintaining (PM) femtosecond fiber laser source at 1100 nm. The is seeded by an PM mode-locked employing nonlinear amplifying loop mirror. seed can generate stable pulses fundamental repetition rate of 40.71 MHz with signal-to-noise >100 dB and integrated relative intensity noise only ~0.061%. After two-stage external amplification pulse compression, output power ~1.47 W (corresponding to energy ~36.1 nJ) duration ~251 fs are obtained. nm...
Multimodal Large Language Models (MLLMs) have shown promising progress in understanding and analyzing video content. However, processing long videos remains a significant challenge constrained by LLM's context size. To address this limitation, we propose LongVU, spatiotemporal adaptive compression mechanism thats reduces the number of tokens while preserving visual details videos. Our idea is based on leveraging cross-modal query inter-frame dependencies to adaptively reduce temporal spatial...
Abstract Krüppel-like transcription factor 7 (KLF7) promotes preadipocyte proliferation; however, its target gene in this process has not yet been identified. Using KLF7 ChIP-seq analysis, we previously showed that a KLF7-binding peak is present upstream of the cyclin-dependent kinase inhibitor 3 ( CDKN 3) chicken preadipocytes. In current study, identified as mediates effects on proliferation. Furthermore, 5′-truncating mutation analysis minimal promoter was located between nt −160 and −7...
The impact of certain extreme events on the construction index is greatly importance which could be viewed as a huge turning to index. In paper, Wenchuan Earthquake China would chosen event and an EMD-based (Empirical Mode Decomposition) analysis approach used test earthquake’s impact. proposed method, t-test necessary prove significant level say earthquake did have influence change (399235.SZ) measured in Shenzhen stock market. Then time series decomposed into six different modes one...