A5100404453- RNA modifications and cancer
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Plant Reproductive Biology
- Bacteriophages and microbial interactions
- Heat Transfer and Boiling Studies
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Gut microbiota and health
- Luminescence Properties of Advanced Materials
- Pancreatic and Hepatic Oncology Research
- Fluid Dynamics and Heat Transfer
- Cardiac Valve Diseases and Treatments
- Heat Transfer and Optimization
- Bacterial Identification and Susceptibility Testing
- Pharmacological Effects of Natural Compounds
- Hydrological Forecasting Using AI
- Cancer Mechanisms and Therapy
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Harbin Medical University
2011-2025
Xuzhou University of Technology
2024-2025
Changzhi Medical College
2024-2025
Guangxi University
2025
Army Medical University
2024-2025
Northwest A&F University
2024-2025
Children's Hospital of Chongqing Medical University
2025
Shandong Academy of Agricultural Sciences
2022-2024
First Affiliated Hospital of Harbin Medical University
2011-2024
Yantai University
2023-2024
Previous studies have reported the value of quantitative flow ratio (QFR) to assess physiological significance non-culprit lesions (NCLs) in acute myocardial infarction (AMI) patients and optical coherence tomography (OCT)-defined thin-cap fibroatheroma (TCFA) identify vulnerable plaques. We sought systematically compare long-term NCL-related clinical prognosis an AMI population utilising Murray fractal law-based QFR (μQFR) values OCT-defined TCFA. Three-vessel OCT imaging μQFR assessment...
To explore the association of systemic inflammatory index (SIRI), immune-inflammatory (SII) and prognosis (IPI) with 90d outcomes in patients acute ischemic stroke (AIS) after intravenous thrombolysis.The who underwent thrombolysis were enrolled present study from September 2019 to December 2022. According relevant blood indexes obtained 24 h admission, corresponding values SIRI, SII IPI calculated. The correlation among SII, IPI, admission NIHSS scores was examined by Spearman analysis. ROC...
Abstract Lung cancer (LC) is regarded as a fatal cancer, and insulin-like growth factor 1 (IGF1) its receptor (IGF1R) have been found to play key role in regulating tumor glycolytic metabolism. The aim of this study investigate LC proliferation regulated by metabolite-mediated IGF1R lactylation. was highly expressed tissues cells, the effects on protein stability were inhibited Lactate dehydrogenase A (LDHA) inhibition. Moreover, tightness binding IGF1 also enhanced exogenous lactic acid but...
Halobenzoquinones (HBQs), an emerging unregulated category of disinfection byproduct (DBP) in drinking water, have aroused increasing concern over their potential health risks. However, the chronic toxicity HBQs at environmentally relevant concentrations remains largely unknown. Here, occurrence and 13 water from a northern megacity China were examined using ultrahigh performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (UHPLC–MS/MS). Four HBQs, including...
Recently, the structural optimization of natural bioactive products has been one important ways to discover new pesticide candidates. Based on osthole as a lead compound, herein, series 2-isopropanol-4-methoxy-7-alkyl/aryloxycarbonyl-(E)-vinyl-2,3-dihydrobenzofuran derivatives were synthesized. Steric configurations compounds 3, 4, 6, 9, 11, 29, and 31 confirmed by X-ray monocrystallography. Notably, an efficient method for preparation 2-isopropanol-2,3-dihydrobenzofurans from epoxidation...
Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether due to stenosis severity or the underlying high-risk lesion morphology. Between January 2017 December 2021, 1312 patients underwent optical coherence tomography of all 3 main epicardial arteries after successful percutaneous coronary intervention. were categorized according presence...
X-ray nondestructive testing technology is widely used for inspecting welds and identifying defects, crucial in the manufacturing industry. However, diversity of welding defects imbalanced defect samples reduce classification model accuracy can cause classifier overfitting. This paper proposes an improved DCGAN generating by integrating deep convolutional neural networks to enhance training relationship between generator discriminator, thus increasing number samples. We introduce a...
Colorectal cancer (CRC) is a common malignant tumor. N6-Methyladenosine (m6A) modification plays an important role in the regulation of glycolysis tumor cells and may be potential target for therapy. The METTL14, m6A writer, CRC was investigated through functional assays including cell viability, colony formation, glycolysis-related measurements (glucose uptake, lactate production, extracellular acidification rate (ECAR) oxygen consumption (OCR)). gene regulated by METTL14 m6A-dependent...
To present 2 cases of placental rupture at delivery after fetoscopic SOLOMON technique for twin-twin transfusion syndrome. diagnosed with TTTS in the second trimester. Fetoscopic procedure was performed successfully subsequently. Placental confirmed by cesarean section third All fetuses were survived. No severe maternal complications but postpartum haemorrhage (PPH) detected one cases. The may further result which lead to risk fetal demise and haemorrhage, should pay close attention.
Abstract Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been reported to be a novel surgical technique that provides fast effective growth of liver remnant. Despite occasional reports on animal studies, the mechanisms rapid regeneration in ALPPS remains unclear. In present study, we intend develop reproducible rat model mimick explore underlying mechanisms. Rats assigned portal (PVL), left lateral lobe (LLL) resection, transection sham groups served...
Traditional Chinese medicines (TCMs) represent one form of complementary and alternative medicine. The popularity complexity in production make them attractive vulnerable to adulteration stages ranging from planting production. Adulteration refers the addition extraneous, improper, or inferior ingredients that should not be present TCMs. To detect combat adulterated TCMs, supplementary testing methods (STMs), which expand capability routine standards, have been applied China since 2003. From...
Abstract Dysfunction in T-cell antitumor activity contributes to the tumorigenesis, progression, and poor outcome of clear cell renal carcinoma (ccRCC), with this dysfunction resulting from high expression programmed death-1 (PD-1) T cells. However, molecular mechanisms maintaining PD-1 cells have not been fully investigated ccRCC. Here, we describe a mechanism underlying regulation at mRNA level demonstrated its impact on dysfunction. Transcriptomic analysis identified correlation between...
Salidroside (Sal), the main component of a famous herb Rhodiola rosea L, enhances memory performance and reduces fatigue. Therefore, this study assessed effect Sal on impairment induced by long-term intake ethanol (EtOH) in rats investigated its relevant mechanisms using gut microbiota metagenomic analysis hippocampal transcriptomic analysis.Eighteen male SD were divided into normal control group (CON group), EtOH model (Model treatment (Sal group). The Model groups intragastrically (i.g.)...
This research examined the impact of incorporating Angelica sinensis's aerial components (APA), commonly referred to as "female ginseng", into broilers' diet. Two hundred eighty-eight 1-day-old Cobb 500 broilers were randomly assigned 4 experimental groups with 6 replications and 12 birds/replicate. The fed diets included concentrations APA (0 %, 1 2 3%, respectively). study spanned 42 days, categorized starter phase (1-21 days) finisher (22-42 days). Notably, 3% demonstrated a pronounced...
Phage therapy is gaining momentum as an alternative to antibiotics in the treatment of salmonellosis caused by Salmonella. In this study, a novel Salmonella phage, vB_SalS_JNS02, was isolated successfully from poultry farms Shandong, China. The biological characteristics vB_SalS_JNS02 were analysed, which revealed short latent period approximately 10 min and burst size 110 PFU/cell. Moreover, exhibited remarkable stability across wide pH range (pH 3-12) temperatures ranging 30 80°C. Genome...
is a common opportunistic pathogen. The potential efficacy of phage therapy has attracted the attention researchers, but efficient gene-editing tools are lacking, limiting study their biological properties. Here, we designed type V CRISPR-Cas12a system for gene editing
This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin receptor (AT1R) signaling pathway subsequently alleviating damage. db/db mice were divided randomly into a diabetic nephropathy (DN) group UA treatment group. Light microscopy electron used observe pathological changes in tissues. Immunohistochemistry (IHC) was employed examine expression...