A5100601552- Congenital Heart Disease Studies
- Acute Ischemic Stroke Management
- Tracheal and airway disorders
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Structural Anomalies and Repair
- Mesenchymal stem cell research
- Inflammatory Biomarkers in Disease Prognosis
- Nutrition and Health in Aging
- Thyroid and Parathyroid Surgery
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Cardiac Arrest and Resuscitation
- Vascular Anomalies and Treatments
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Climate Change and Health Impacts
- Immune Response and Inflammation
- Connective Tissue Growth Factor Research
- Pulmonary Hypertension Research and Treatments
Nanjing University of Chinese Medicine
2017-2025
Jiangsu Province Hospital
2019-2025
Hebei Medical University
2025
Nankai University
2024
State Key Laboratory of Medicinal Chemical Biology
2024
Beijing YouAn Hospital
2018-2022
Capital Medical University
2018-2022
Shanghai Stomatological Hospital
2022
Nanjing Medical University
2006-2022
Guangzhou Medical University
2019-2022
Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at single-cell resolution.The osteoimmunology microenvironment in the occurrence and development periodontitis remains poorly understood level.In this study, we used transcriptomics to comprehensively reveal complexities molecular components differences with counterparts residing periodontal tissues.Methods: We performed scRNA-seq identify 51248 single cells from healthy controls (n=4), patients severe...
To explore the association of systemic inflammatory index (SIRI), immune-inflammatory (SII) and prognosis (IPI) with 90d outcomes in patients acute ischemic stroke (AIS) after intravenous thrombolysis.The who underwent thrombolysis were enrolled present study from September 2019 to December 2022. According relevant blood indexes obtained 24 h admission, corresponding values SIRI, SII IPI calculated. The correlation among SII, IPI, admission NIHSS scores was examined by Spearman analysis. ROC...
25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) are linked both associated with changes in mortality. We examined the association of 25(OH)D PA all-cause or cause-specific mortality risk stroke survivors. The analysis included 677 survivors from National Health Nutrition Examination Survey (NHANES) 2007–2008 to 2017–2018. Independent joint associations 25(OH)D, among were analyzed using weighted Cox regression. identified 133 deaths [major adverse cardiovascular...
BACKGROUND To detect the expression of lncRNA HOXA11-AS and its biological effect in breast cancer. MATERIAL AND METHODS In this study, fluorescent quantitative real-time PCR (qRT-PCR), MTT assay clone formation assay, flow cytometry, Transwell wound healing immunofluorescence, Western blot analysis were conducted to HOXA11-AS, cell proliferation activity, apoptosis rate cycle distribution, changes invasion metastasis capacity, expressions molecular markers epithelial-mesenchymal transition...
Significance Statement Although mesenchymal stem cells might have potential for treating SLE, their immunoregulatory plasticity renders therapeutic effects unpredictable. The authors genetically modified to overexpress IL-37—a protein with immunosuppressive activity—and assessed the cells’ on immune suppression in vitro , as well of transplanting such into a mouse model SLE. Mice transplanted IL-37–overexpressing displayed improved survival and reduced signs SLE compared controls. Expression...
The identification of high-sensitivity biomarkers for detection hepatocellular carcinoma (HCC) from high-risk individuals is essential.The present study was undertaken to identify and validate serum microRNAs (miRNAs) as potential hepatitis C virus (HCV)-related HCC.Illumina sequencing employed screen the expression profiles miRNAs in samples HCV-related HCC patients liver cirrhosis (LC) patients. RT-qPCR used confirm altered between two groups. Moreover, candidate were examined 40 patients,...
Abstract Objectives Mesenchymal stem cells (MSCs) have been intensively investigated as to their therapeutic potentials. However, the full chemical-defined medium supporting isolation and expansion of human MSCs has not developed yet. Materials methods Here, we medium, NBVbe via RNA sequencing, bioinformatic analysis, growth factor screening. Results The contains N2B27 with BSA (bovine serum albumin) replaced by recombinant albumin, bFGF (basic fibroblast factor), vitamin C, EGF (epidermal...
To identify associations between anthropometric indicators (height, weight and body mass index (BMI)) both refraction ocular biometrics in Chinese schoolchildren Tianjin, China. Cross-sectional study. A total of 482 (86.07%) students (6-15 years old) with no history or systemic pathologies were enrolled this Height measured using standardised protocols. Ocular (axial length (AL), vitreous chamber depth (VCD) corneal curvature (CC)) by a low-coherence optical reflectometry device. Cycloplegic...
Inflammatory markers for the prognosis of acute ischemic stroke (AIS) with endovascular therapy remain unclear. The purpose this study was to investigate association between systemic inflammatory response index (SIRI) and neutrophil-to-lymphocyte ratio (NLR) unfavorable functional outcomes at 90-day in individuals AIS who underwent therapy. A total 128 patients had were enrolled from Nanjing Stroke Registry September 2019 November 2022. Peripheral venous blood collected within 24 h admission...
After surgery performed under cardiopulmonary bypass (CPB), severe lung injury often occurs in infants. MicroRNAs (miRNAs) are potentially involved diverse pathophysiological processes via regulation of gene expression. The objective this study was to investigate differentially expressed miRNAs and their potential target genes immature piglet lungs response CPB. Fourteen piglets aged 18.6 ± 0.5 days were equally divided into two groups that underwent sham sternotomy or duration aortic...
The contribution of individual and combined inflammatory markers for the prognosis acute ischemic stroke (AIS) remains elusive. This study investigated effect systemic response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), which is mediated by fasting blood glucose (FBG), on 90-day patients with AIS.
The lymphatic system plays a crucial role in the maintenance of tissue fluid homeostasis and immunological response to inflammation. effects drainage dysfunction on periodontitis have not been well studied. Here we show that vessel endothelial receptor 1 (LYVE1)+ /podoplanin (PDPN)+ vessels (LVs) are increased periodontal tissues, with accumulation close alveolar bone surface, two murine models: rheumatoid arthritis (RA)-associated ligature-induced periodontitis. Further, PDPN+ /alpha-smooth...
Abstract Purposes The incidence of thyroid cancer has increased annually, and a heavy psychological economic burden on society individuals. Based data from patients treated in Liaocheng People's Hospital 2015 to 2018, with Chinese national regional characteristics, this study, we addressed the controversy which initial surgical mode, lobectomy or total thyroidectomy, is most effective. Methods Clinical pathological 2108 cancer, who were initially diagnosed surgically, collected Department...
Metronidazole, a common antimicrobial agent, can induce encephalopathy in rare cases. After discontinuing metronidazole, most patients show clinical improvement. However, the face of deteriorating conditions, there have done not to reports effective drug treatment. A 57-year-old man was admitted our hospital due dysarthria and ataxic gait after taking metronidazole at dose about 32 g for 20 days. Neurological examination showed that his upward outward movements bilateral eyeballs were...