Zhen Wu

ORCID: 0000-0001-9958-6299
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About
Contact & Profiles
Research Areas
  • Meningioma and schwannoma management
  • Vascular Malformations Diagnosis and Treatment
  • Thyroid Cancer Diagnosis and Treatment
  • Corneal surgery and disorders
  • Spinal Fractures and Fixation Techniques
  • Bone Tumor Diagnosis and Treatments
  • Neurofibromatosis and Schwannoma Cases
  • Thyroid and Parathyroid Surgery
  • Glaucoma and retinal disorders
  • Oral and Maxillofacial Pathology
  • Glioma Diagnosis and Treatment
  • Radiomics and Machine Learning in Medical Imaging
  • Tumors and Oncological Cases
  • Cancer-related molecular mechanisms research
  • Intracranial Aneurysms: Treatment and Complications
  • Peptidase Inhibition and Analysis
  • Ophthalmology and Visual Impairment Studies
  • Intraocular Surgery and Lenses
  • Sarcoma Diagnosis and Treatment
  • Parvovirus B19 Infection Studies
  • Histiocytic Disorders and Treatments
  • Pituitary Gland Disorders and Treatments
  • Osteoarthritis Treatment and Mechanisms
  • Cerebrospinal fluid and hydrocephalus
  • Corneal Surgery and Treatments

Capital University
2022-2025

Capital Medical University
2015-2025

Third Affiliated Hospital of Sun Yat-sen University
2021-2025

Sun Yat-sen University
2021-2025

Tianjin Foreign Studies University
2025

Tianjin University
2025

Shandong First Medical University
2020-2024

Liaocheng People's Hospital
2019-2024

Hangzhou Cancer Hospital
2024

Beijing Tian Tan Hospital
2012-2023

The incidence of papillary thyroid cancer (PTC) has recently increased. Although PTC usually a good prognosis, patients with advanced or localized metastases experience high rate recurrence. many studies have investigated recurrence, correlation between location and recurrence remains unclear. Thus, we aimed to determine whether the affects recurrence.Data were obtained from single surgery center > 6000 surgical cases per year. Between 2009 2022, 17,995 enrolled in this study after...

10.1038/s41598-025-95708-1 article EN cc-by-nc-nd Scientific Reports 2025-03-27

BACKGROUND. Lower-grade gliomas (LGGs) vary widely in terms of the patient's overall survival (OS). There is no current, valid method that could exactly predict survival. The effects intratumoral immune infiltration on clinical outcome have been reported. Thus, we aim to develop an signature LGG patients.

10.1172/jci.insight.133811 article EN cc-by JCI Insight 2020-03-31

Abstract Osteoarthritis (OA) is a chronic degenerative joint disease with its onset closely related to the growth of synovial fibroblasts (SFs), yet genes involved in are few reported. In our study, we aimed identify OA-associated key gene and pathways via single-cell RNA sequencing (scRNA-seq) analysis on SFs. scRNA-seq data SFs from OA sufferers were accessed GEO database, then subjected principal component (PCA) T-Stochastic Neighbor Embedding (TSNE) Analysis. GO KEGG enrichment analyses...

10.1097/md.0000000000021707 article EN cc-by-nc Medicine 2020-08-13

Abstract Purposes The incidence of thyroid cancer has increased annually, and a heavy psychological economic burden on society individuals. Based data from patients treated in Liaocheng People's Hospital 2015 to 2018, with Chinese national regional characteristics, this study, we addressed the controversy which initial surgical mode, lobectomy or total thyroidectomy, is most effective. Methods Clinical pathological 2108 cancer, who were initially diagnosed surgically, collected Department...

10.1002/cam4.3743 article EN cc-by Cancer Medicine 2021-01-29

Postoperative cerebral edema is common in patients with meningioma. It of great clinical significance to predict the postoperative exacerbation (CEE) for development individual treatment programs meningioma.To evaluate value three-dimensional radiomics Features from Multi-Parameter MRI predicting CEE meningioma.A total 136 meningioma complete and radiological data were collected this retrospective study, they randomly divided into primary validation cohorts. Three-dimensional features...

10.3389/fonc.2021.625220 article EN cc-by Frontiers in Oncology 2021-04-15

Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before final option knee replacement, arthroscopic surgery was widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to forefront treatment prevent progression OA. Currently, MFAT has successfully applied treat different types orthopedic diseases.

10.4252/wjsc.v15.i12.1063 article EN cc-by-nc World Journal of Stem Cells 2023-12-25

Objective: Intracranial pineoblastomas are rare neoplasms with poor prognosis. The aim of this study was to describe the independent prognostic factors and treatment strategies for overall survival in pediatric adult patients. Methods: Sixty-four patients were surgically treated between January 2012 December 2018. Results: series included 37 (57.8%) males 27 (42.2%) females. Gross total resection achieved 41 (64.1%) cases, 1-, 3-, 5-year rates 86.3, 52.3, 36.6%, respectively. In group...

10.2147/cmar.s258476 article EN cc-by-nc Cancer Management and Research 2020-08-01

Retinal vein occlusion (RVO) was a vision-threatening retinal vascular disorder, however, the relationship between obstructive sleep apnea (OSA) and RVO risk remained unclear.A total of 45 cases controls April 2018 2020 were included. All participants underwent full-night polysomnography (PSG) thus detected severity OSA. Besides, apnea-hypopnea index (AHI) oxidative inflammatory biomarkers, including 8-hydroxy-2 deoxyguanosine (8-OHdG), C-reactive protein (CRP), interleukin 1 beta (IL1β), 6...

10.2147/nss.s290583 article EN cc-by-nc Nature and Science of Sleep 2021-03-01

Skull-base chordomas are rare malignant bone cancers originating from the remnant of notochord. Survival is variable, and clinical or molecular factors cannot reliably predict their outcomes. This study therefore identified epigenetic subtypes that defined new chordoma profiles corresponding characteristics.Methylation 46 chordoma-resected neoplasms between 2008 2014, along with information, were collected. K-means consensus clustering principal component analysis used to identify validate...

10.3389/fonc.2022.960005 article EN cc-by Frontiers in Oncology 2022-11-11

Obstructive sleep apnea (OSA) is related to an increased incidence of dry eye disease (DED). However, their exact relationship unknown and requires further well-designed studies with advanced mechanisms detection.This case-control study included 125 OSA cases age-gender-matched controls enrolled in the hospital between 1 January October 2021. diagnosis classification were performed using a polysomnography (PSG) assay. Detailed ophthalmological examinations, including Schirmer I test, corneal...

10.3389/fmed.2022.870391 article EN cc-by Frontiers in Medicine 2022-10-31

Primary intracranial rhabdomyosarcoma (PIRMS) is rare, and the effects of treatment strategy on overall survival (OS) are unclear. This study aimed to evaluate risk factors pertinent OS propose an optimal strategy.

10.3171/2019.6.jns19752 article EN Journal of neurosurgery 2019-09-14

IJS Oncology is a peer-reviewed, international, open access journal seeking to publish in the broad field of oncology, including surgical, medical and radiation oncology. The Journal aims basic science, educational, clinical translational research articles. We aim provide rapid submission decision times whilst maintaining high quality peer-review process.The science practice oncology rapidly developing field. It has become increasingly interdisciplinary through recognition efficacy...

10.1097/ij9.0000000000000081 article EN cc-by International Journal of Surgery Oncology 2019-01-01

Objective There is still controversy about whether cervical lymph node dissection should be performed in surgical treatment of PTC. Based on the data thyroid cancer patients from Liaocheng People’s Hospital 2015 to 2018, this study focused appropriate indications for surgery. Methods The clinical and pathological with initial PTC surgery department 2018 were collected. In all cases, 1001 underwent total thyroidectomy + central dissection, 1107 dissection. Results average metastasis rate...

10.3389/fonc.2024.1280607 article EN cc-by Frontiers in Oncology 2024-04-05

Papillary thyroid microcarcinoma (PTMC) is a specific subgroup of papillary carcinoma and defined with the dimension ≤1 cm by WHO. Although it shows relatively high 10-year livability, metastasis PTMC into other tissues organs seriously affects daily life patients mortality. Therefore, genetic basis for needs to be explored effective therapeutic targets. Here, we conducted series comparative analysis transcriptional expression profile between without lymph node metastasis.Gene gene function...

10.1159/000518085 article EN ORL 2021-10-14
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